Hspb7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hspb7
heat shock protein family, member 7 (cardiovascular)
MGI:1352494

24 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hspb7^tm1.1Chen/Hspb7^tm1.1Chen Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	abnormal heart morphology	J:256653
	embryonic lethality during organogenesis, complete penetrance	J:256653
Hspb7^tm1.1Chen/Hspb7^tm1.1Chen Tg(Tnnt2-cre)5Blh/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	embryonic lethality during organogenesis, complete penetrance	J:256653
Hspb7^tm1.1Yty/Hspb7^tm1.1Yty Tg(ACTA1-cre)79Jme/0 involves: 129 * C57BL/6J * SJL	abnormal diaphragm morphology	J:246267
	abnormal forced expiratory flow rates	J:246267
	abnormal respiratory function	J:246267
	abnormal sarcomere morphology	J:246267
	abnormal Z line morphology	J:246267
	centrally nucleated skeletal muscle fibers	J:246267
	decreased body weight	J:246267
	decreased grip strength	J:246267
	increased circulating creatine kinase level	J:246267
	myopathy	J:246267
	postnatal lethality, incomplete penetrance	J:246267
	premature death	J:246267
	skeletal muscle fibrosis	J:246267
Hspb7^tm1.2Chen/Hspb7^tm1.2Chen involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal cardinal vein morphology	J:256653
	abnormal fetal cardiomyocyte morphology	J:256653
	abnormal sarcomere morphology	J:256653
	abnormal trabecula carnea morphology	J:256653
	abnormal Z line morphology	J:256653
	congestive heart failure	J:256653
	decreased fetal cardiomyocyte proliferation	J:256653
	decreased heart left ventricle size	J:256653
	decreased heart right ventricle wall thickness	J:256653
	embryonic lethality during organogenesis, complete penetrance	J:256653
	globular heart	J:256653
	small heart	J:256653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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