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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Esr1
estrogen receptor 1 (alpha)
MGI:1352467
99 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Esr1tm1.1Mma/Esr1+
involves: 129S2/SvPas * C57BL/6J 		abnormal colon goblet cell morphology J:118600
abnormal enterocyte proliferation J:118600
abnormal intestinal mucosa morphology J:118600
abnormal large intestine crypts of Lieberkuhn morphology J:118600
increased carcinoma incidence J:118600
increased colon adenoma incidence J:118600
increased gastrointestinal tumor incidence J:118600
ApcMin/Apc+
Esr1tm1.1Mma/Esr1tm1.1Mma
involves: 129S2/SvPas * C57BL/6J 		preweaning lethality, complete penetrance J:118600
Apoetm1Bres/Apoetm1Bres
Esr1tm1Ksk/Esr1tm1Ksk
B6.129P2-Apoetm1Bres Esr1tm1Ksk 		abnormal circulating cholesterol level J:68574
atherosclerotic lesions J:68574
normal homeostasis/metabolism phenotype J:68574
increased susceptibility to atherosclerosis J:68574
uterus atrophy J:68574
Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB 		increased mammary gland tumor incidence J:132088
mammary gland alveolar hyperplasia J:132088
preneoplasia J:132088
Esr1tm1.1Mma/Esr1+
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal response/metabolism to endogenous compounds J:64426
absent corpus luteum J:64426
impaired granulosa cell differentiation J:64426
increased tertiary ovarian follicle number J:64426
reduced female fertility J:64426
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal response/metabolism to endogenous compounds J:64426
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal ovarian follicle morphology J:64426
abnormal ovary morphology J:64426
abnormal response/metabolism to endogenous compounds J:64426
abnormal rete testis morphology J:64426
abnormal seminiferous tubule morphology J:64426
abnormal Sertoli cell morphology J:64426
abnormal tertiary ovarian follicle morphology J:64426
decreased male germ cell number J:64426
decreased theca cell number J:64426
impaired granulosa cell differentiation J:64426
increased atretic ovarian follicle number J:64426
male infertility J:64426
ovarian follicular cyst J:64426
small vagina J:64426
thin uterus J:64426
uterus hypoplasia J:64426
vagina hypoplasia J:64426
Esr1tm1.1Mma/Esr1tm1.1Mma
Ldlrtm1Her/Ldlrtm1Her
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal response/metabolism to endogenous compounds J:144952
increased susceptibility to atherosclerosis J:144952
Esr1tm1Arnal/Esr1tm1Arnal
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd 		abnormal response/metabolism to endogenous compounds J:144952
increased susceptibility to atherosclerosis J:144952
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd 		abnormal ovary morphology J:59105
abnormal vertebrae morphology J:111108
absent corpus luteum J:59105
asthenozoospermia J:59105
female infertility J:59105
increased body length J:111108
increased circulating luteinizing hormone level J:59105
long femur J:111108
male infertility J:59105
oligozoospermia J:59105
uterus hypoplasia J:59105
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell number J:82423
abnormal bone marrow cell number J:82423
abnormal class switch recombination J:82423
abnormal immunoglobulin level J:82423
abnormal response/metabolism to endogenous compounds J:82423, J:115411
abnormal sexual interaction J:66582
abnormal uterus weight J:115411
decreased aggression towards male mice J:66582
decreased areal bone mineral density J:62222
decreased body weight J:62222
decreased bone mineral content J:62222
decreased bone mineral density of femur J:62222
decreased CD4-positive, alpha-beta T cell number J:110416
decreased CD8-positive, alpha-beta T cell number J:110416
decreased circulating insulin-like growth factor I level J:62222
decreased circulating osteocalcin level J:62222
decreased compact bone area J:62222
decreased femoral compact bone area J:62222
decreased spleen weight J:110416
decreased uterus weight J:115411
failure of ejaculation J:66582
increased aggression towards female mice J:66582
increased circulating cholesterol level J:66077
increased circulating HDL cholesterol level J:66077
increased circulating leptin level J:66077
increased double-positive T cell number J:110416
increased gonadal fat pad weight J:66077
increased retroperitoneal fat pad weight J:66077
increased total body fat amount J:66077
insulin resistance J:66077
obese J:66077
short femur J:62222
thymus hypoplasia J:110416
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
Inhatm1Bay/Inha+
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal ovary morphology J:84989
increased ovary tumor incidence J:84989
Esr1tm1Ksk/Esr1tm1Ksk
Esr2tm1Unc/Esr2tm1Unc
Inhatm1Bay/Inhatm1Bay
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal ovary morphology J:84989
abnormal seminiferous tubule morphology J:84989
cachexia J:84989
decreased body weight J:84989
decreased circulating follicle stimulating hormone level J:84989
decreased male germ cell number J:84989
dilated seminiferous tubule J:84989
increased body weight J:84989
increased ovary tumor incidence J:84989
increased testis tumor incidence J:84989
premature death J:84989
Esr1tm1Ksk/Esr1tm1Ksk
Inhatm1Bay/Inhatm1Bay
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal hepatocyte morphology J:84989
abnormal stomach glandular epithelium morphology J:84989
abnormal stomach mucosa morphology J:84989
cachexia J:84989
decreased body weight J:84989
decreased circulating follicle stimulating hormone level J:84989
decreased circulating luteinizing hormone level J:84989
hepatic necrosis J:84989
increased circulating estradiol level J:84989
increased ovary tumor incidence J:84989
increased testis tumor incidence J:84989
kyphoscoliosis J:84989
liver inflammation J:84989
premature death J:84989
Esr1tm1Ksk/Esr1tm1Ksk
Tg(MMTV-Erbb2)NK1Mul/0
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal mammary gland development J:76653
increased mammary gland tumor incidence J:76653
increased tumor latency J:76653
Esr1tm1Ksk/Esr1tm1Ksk
Tg(Wnt1)1Hev/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal mammary gland development J:54215
increased mammary adenocarcinoma incidence J:54215
increased tumor latency J:54215
mammary gland alveolar hyperplasia J:54215
mammary gland duct hyperplasia J:54215
mammary gland hyperplasia J:54215
Esr1tm4.2Ksk/Esr1tm4.2Ksk
Mir22tm1Boet/Mir22tm1Boet
involves: 129S2/SvPas * C57BL/6 		normal growth/size/body region phenotype J:266382
Esr1tm4.2Ksk/Esr1tm4.2Ksk
Mir22tm1Boet/Mir22tm1Boet
Tg(Ckmm-cre)5Khn/0
involves: 129S2/SvPas * C57BL/6 * FVB 		normal adipose tissue phenotype J:266382
normal growth/size/body region phenotype J:266382
increased fatty acid oxidation J:266382
normal muscle phenotype J:266382
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory