Nr1h2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nr1h2
nuclear receptor subfamily 1, group H, member 2
MGI:1352463

32 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nr1h2^tm1.1Gstr/Nr1h2⁺ involves: 129 * C57BL/6	normal reproductive system phenotype	J:101966
Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr involves: 129 * C57BL/6	abnormal Sertoli cell morphology	J:101966
Nr1h2^tm1.1Gstr/Nr1h2^tm1.1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cellular cholesterol metabolism	J:82096
	abnormal lipid level	J:234268
	abnormal lung morphology	J:234268
	abnormal oligodendrocyte morphology	J:278794
	abnormal optic nerve morphology	J:278794
	abnormal retina ganglion cell morphology	J:278794
	abnormal retina morphology	J:278794
	abnormal retina nerve fiber layer morphology	J:278794
	amyloid beta deposits	J:278794
	decreased oligodendrocyte number	J:278794
	decreased retina ganglion cell number	J:278794
	increased microglial cell activation	J:278794
	optic nerve degeneration	J:278794
Nr1h2^tm1.1Nph/Nr1h2^tm1.1Nph B6.129-Nr1h2^tm1.1Nph	abnormal cellular cholesterol metabolism	J:169945
	abnormal cholesterol homeostasis	J:169945
	abnormal glucose homeostasis	J:169945
	abnormal glycogen homeostasis	J:169945
	abnormal lipid homeostasis	J:169945
	increased muscle cell glucose uptake	J:169945
Nr1h2^tm1Dgen/Nr1h2^tm1Dgen B6.129-Nr1h2^tm1Dgen	abnormal skeleton physiology	J:157551
Nr1h2^tm1Djm/Nr1h2^tm1Djm involves: 129S6/SvEvTac	thin epidermis	J:89874
Nr1h2^tm1Djm/Nr1h2^tm1Djm involves: 129S6/SvEvTac * C57BL/6	abnormal myometrium morphology	J:120923
	abnormal parturition	J:120923
	abnormal Sertoli cell morphology	J:120913
	abnormal spermatogonia proliferation	J:120913
	abnormal uterus physiology	J:120923
	hindlimb paralysis	J:120923
	impaired smooth muscle contractility	J:120923
	increased susceptibility to bacterial infection	J:81696
	increased susceptibility to induced morbidity/mortality	J:81696
	pregnancy-related premature death	J:120923
Nr1h2^tm1Gstr/Nr1h2^tm1Gstr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	no abnormal phenotype detected	J:82096

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23