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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nr1h3
nuclear receptor subfamily 1, group H, member 3
MGI:1352462
40 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nr1h3tm1.1(KOMP)Vlcg/Nr1h3tm1.1(KOMP)Vlcg
C57BL/6N-Nr1h3tm1.1(KOMP)Vlcg/Ucd
abnormal kidney morphology J:211773
abnormal seminal vesicle morphology J:211773
decreased circulating triglyceride level J:211773
decreased heart weight J:211773
increased hematocrit J:211773
Nr1h3tm1.1Djm/Nr1h3tm1.1Djm
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S/SvEv * C57BL/6 * DBA
abnormal lipid homeostasis J:184536
decreased physiological sensitivity to xenobiotic J:184536
increased liver cholesterol level J:184536
increased liver weight J:184536
Nr1h3tm1.1Gstr/Nr1h3tm1.1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cellular cholesterol metabolism J:82096
enlarged liver J:82096
increased circulating alanine transaminase level J:82096
increased circulating LDL cholesterol level J:82096
increased liver cholesterol level J:82096
pale liver J:82096
normal respiratory system phenotype J:234268
Nr1h3tm1.1Nph/Nr1h3tm1.1Nph
B6.129-Nr1h3tm1.1Nph
normal homeostasis/metabolism phenotype J:169945
Nr1h3tm1Dgen/Nr1h3tm1Dgen
Not Specified
abnormal cholesterol homeostasis J:112995
abnormal hepatobiliary system physiology J:112995
abnormal lipid homeostasis J:112995
Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
abnormal bile salt homeostasis J:47971
abnormal corpus luteum morphology J:158168
abnormal male germ cell apoptosis J:120913
abnormal ovary physiology J:158168
abnormal superovulation J:158168
decreased circulating luteinizing hormone level J:120913
decreased circulating testosterone level J:120913
enlarged ovary J:158168
hepatic steatosis J:47971
normal homeostasis/metabolism phenotype J:243753
increased circulating alanine transaminase level J:47971
increased circulating aspartate transaminase level J:47971
increased circulating cholesterol level J:47971
increased circulating estradiol level J:158168
increased circulating LDL cholesterol level J:47971
increased inflammatory response J:158168
increased liver cholesterol level J:47971, J:243753
increased liver weight J:47971
increased sensitivity to induced morbidity/mortality J:81696
increased susceptibility to bacterial infection J:81696
increased vascular permeability J:158168
liver degeneration J:47971
ovary cysts J:158168
ovary hemorrhage J:158168
pale liver J:47971
Nr1h3tm1Gstr/Nr1h3tm1Gstr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
no abnormal phenotype detected J:82096
Nr1h3tm1Wexi/Nr1h3tm1Wexi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
decreased susceptibility to endotoxin shock J:155709
hepatic steatosis J:155709
Tg(Fabp1-Nr1h3)#Wexi/?
involves: 129X1/SvJ * C57BL/6
enlarged liver J:135594
hepatic steatosis J:135594
increased liver triglyceride level J:135594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory