Trpm2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Trpm2
transient receptor potential cation channel, subfamily M, member 2
MGI:1351901

26 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Trpm2^tm1.1Alp/Trpm2^tm1.1Alp B6.129P2-Trpm2^tm1.1Alp	decreased circulating interferon-gamma level	J:174397
	decreased circulating interleukin-12 level	J:174397
	decreased circulating interleukin-12b level	J:174397
	decreased interferon-gamma secretion	J:174397
	decreased interleukin-12 secretion	J:174397
	increased susceptibility to bacterial infection	J:174397
	increased susceptibility to bacterial infection induced morbidity/mortality	J:174397
	liver abscess	J:174397
Trpm2^tm1.1Jych/Trpm2^tm1.1Jych involves: FVB/N	abnormal myocardial fiber morphology	J:196475
	abnormal myocardial fiber physiology	J:196475
	decreased cardiac muscle contractility	J:196475
	increased heart left ventricle size	J:196475
	increased response of heart to induced stress	J:196475
	oxidative stress	J:196475
Trpm2^tm1Lex/Trpm2^tm1Lex B6;129S5-Trpm2^tm1Lex/Mmucd	no abnormal phenotype detected	J:171883
Trpm2^tm1Lhj/Trpm2^tm1Lhj Not Specified	abnormal macrophage morphology	J:202791
Trpm2^tm1Lhj/Trpm2^tm1Lhj Not Specified	abnormal macrophage physiology	J:202791
Trpm2^tm1Yamo/Trpm2^tm1Yamo B6J.129S4-Trpm2^tm1Yamo	abnormal behavioral response to xenobiotic	J:226171
	abnormal brain wave pattern	J:226171
	abnormal social investigation	J:226171
	increased anxiety-related response	J:226171
Trpm2^tm1Yamo/Trpm2^tm1Yamo involves: 129S4/SvJae * C57BL/6J	abnormal interferon level	J:137676
	abnormal interleukin level	J:137676
	abnormal leukocyte physiology	J:137676
	abnormal macrophage physiology	J:137676
	decreased inflammatory response	J:137676
	impaired neutrophil recruitment	J:137676

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23