Prmt5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prmt5
protein arginine N-methyltransferase 5
MGI:1351645

34 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prmt5^{Gt(RRA014)Byg}/Prmt5^{Gt(RRA014)Byg} involves: 129P2/OlaHsd	absent inner cell mass proliferation	J:166736
	embryonic lethality, complete penetrance	J:166736
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL	decreased embryo size	J:201152
	embryonic growth retardation	J:201152
	pallor	J:201152
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(BGLAP-cre)1Clem/0 involves: C57BL/6N * FVB/NJ	normal skeleton phenotype	J:283043
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Col2a1-cre)#Amc/0 involves: C57BL/6N	abnormal chondrocyte morphology	J:283043
	abnormal endochondral bone ossification	J:283043
	abnormal intervertebral disk development	J:283043
	abnormal intervertebral disk morphology	J:283043
	abnormal vertebrae morphology	J:283043
	abnormal vertebral body development	J:283043
	decreased body size	J:283043
	decreased bone mineralization	J:283043
	decreased trabecular bone volume	J:283043
	delayed endochondral bone ossification	J:283043
	preweaning lethality, complete penetrance	J:283043
	scoliosis	J:283043
	small vertebrae	J:283043
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0 involves: C57BL/6N	abnormal intervertebral disk morphology	J:283043
	normal skeleton phenotype	J:283043
Prmt5^{tm2c(EUCOMM)Wtsi}/Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0 B6.Cg-Prmt5^{tm2c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln	abnormal cerebellum external granule cell layer morphology	J:201152
	abnormal cortical plate morphology	J:201152
	abnormal cortical ventricular zone morphology	J:201152
	abnormal embryonic/fetal subventricular zone morphology	J:201152
	abnormal lateral ventricle morphology	J:201152
	abnormal neuronal precursor proliferation	J:201152
	akinesia	J:201152
	decreased brain size	J:201152
	decreased brain weight	J:201152
	enlarged lateral ventricles	J:201152
	impaired balance	J:201152
	increased neuron apoptosis	J:201152
	postnatal lethality, complete penetrance	J:201152
	thin cerebral cortex	J:201152
	tremors	J:201152

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23