About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grm7
glutamate receptor, metabotropic 7
MGI:1351344
87 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Smn1tm1Msd/Smn1tm1Msd
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N 		lethality, complete penetrance J:256720
Mnx1tm4(cre)Tmj/Mnx1+
Smn1tm1Cdid/Smn1tm1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * 129S1/Sv * C57BL/6 * FVB 		abnormal innervation J:183080
abnormal motor coordination/balance J:183080
abnormal righting response J:183080
normal behavior/neurological phenotype J:183080
decreased body weight J:183080
decreased heart rate J:183080
decreased motor neuron number J:183080
irregular heartbeat J:183080
lethargy J:183080
normal nervous system phenotype J:183080
postnatal lethality, complete penetrance J:183080
prolonged PR interval J:183080
prolonged QT interval J:183080
Olig2tm1(cre)Tmj/Olig2+
Smn1tm1Jme/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:164292
Olig2tm1(cre)Tmj/Olig2+
Smn1tm1Jme/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129 * 129P2/OlaHsd * FVB/N 		abnormal CNS synaptic transmission J:164292
abnormal miniature endplate potential J:164292
abnormal muscle morphology J:164292
abnormal neuromuscular synapse morphology J:164292
abnormal PNS synaptic transmission J:164292
abnormal sensory neuron innervation pattern J:164292
abnormal synaptic bouton morphology J:164292
abnormal synaptic transmission J:164292
decreased body weight J:164292
decreased grip strength J:164292
decreased skeletal muscle fiber number J:164292
decreased survivor rate J:164292
increased skeletal muscle fiber size J:164292
kyphosis J:164292
motor neuron degeneration J:164292
muscle weakness J:164292
muscular atrophy J:164292
premature death J:164292
skeletal muscle fiber degeneration J:164292
Smn1tm1Cdid/Smn1tm1.1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * C57BL/6 * FVB 		no abnormal phenotype detected J:183080
Smn1tm1Cdid/Smn1tm1Cdid
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129 * C57BL/6 * FVB 		abnormal innervation pattern to muscle J:183080
abnormal motor capabilities/coordination/movement J:183080
abnormal neuromuscular synapse morphology J:183080
abnormal spinal cord morphology J:183080
decreased body weight J:183080
decreased heart rate J:183080
decreased motor neuron number J:183080
decreased single cell response threshold J:183080
impaired righting response J:183080
motor neuron degeneration J:183080
paralysis J:183080
postnatal lethality, complete penetrance J:183080
prolonged PR interval J:183080
prolonged QRS complex duration J:183080
prolonged QT interval J:183080
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd 		postnatal lethality, complete penetrance J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/?
involves: 129P2/OlaHsd * C57BL/6J * FVB 		abnormal suckling behavior J:60592
bradykinesia J:60592
motor neuron degeneration J:60592
normal muscle phenotype J:60592
perinatal lethality, incomplete penetrance J:60592
postnatal lethality, complete penetrance J:60592
respiratory distress J:60592
tremors J:60592
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*delta7)4299Ahmb/0
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb 		postnatal lethality, complete penetrance J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*A111G)588Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		normal mortality/aging J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7+
Tg(SMN2*A111G)591Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		normal mortality/aging J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd 		decreased body weight J:97103
lethality, complete penetrance J:256720
postnatal lethality, complete penetrance J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J 		abnormal innervation pattern to muscle J:132467
abnormal neuromuscular synapse morphology J:132467
decreased body weight J:194969
decreased skeletal muscle fiber diameter J:132467
normal mortality/aging J:256720
postnatal lethality J:194969
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		prenatal lethality, incomplete penetrance J:164444
thin interventricular septum J:164444
thin ventricular wall J:164444
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*)1951Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*A111G)588Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		abnormal gastrocnemius morphology J:148541
abnormal skeletal muscle morphology J:148541
normal mortality/aging J:148541
normal nervous system phenotype J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*A111G)591Ahmb/0
involves: 129P2/OlaHsd * FVB/N 		normal mortality/aging J:148541
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/0
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J 		cardiac interstitial fibrosis J:194969
decreased body weight J:194969
decreased skeletal muscle fiber size J:194969
postnatal lethality J:194969
thin interventricular septum J:194969
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb 		abnormal gait J:97103
abnormal neuromuscular synapse morphology J:97103
decreased body weight J:97103
decreased motor neuron number J:97103
impaired balance J:97103
impaired limb coordination J:97103
impaired righting response J:97103
postnatal lethality, complete penetrance J:97103
skeletal muscle fiber atrophy J:97103
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J 		abnormal blood flow velocity J:164446
abnormal heart morphology J:164446
abnormal innervation pattern to muscle J:132467
abnormal neuromuscular synapse morphology J:132467
abnormal sympathetic system morphology J:164446
decreased body size J:164446
decreased heart rate J:164446
decreased skeletal muscle fiber diameter J:132467
dilated cardiomyopathy J:164446
increased heart rate variability J:164446
postnatal lethality, complete penetrance J:164446
prolonged PR interval J:164446
prolonged QRS complex duration J:164446
weight loss J:164446
Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
involves: 129P2/OlaHsd * FVB/N 		abnormal artery morphology J:164444
abnormal interventricular septum morphology J:164444
cardiac interstitial fibrosis J:164444
decreased heart rate J:164444
increased heart left ventricle size J:164444
oxidative stress J:164444
prolonged RR interval J:164444
thin interventricular septum J:164444
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		decreased skeletal muscle fiber size J:131663
premature death J:131663
tail necrosis J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		postnatal lethality, complete penetrance J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(Prnp-SMN)92Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		premature death J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(Prnp-SMN)92Ahmb/Tg(Prnp-SMN)92Ahmb
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		decreased skeletal muscle fiber size J:131663
normal nervous system phenotype J:131663
premature death J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7+
involves: 129P2/OlaHsd * FVB/N 		abnormal action potential J:81238
abnormal axon morphology J:81238
abnormal motor nerve collateral sprouting J:81238
abnormal motor neuron morphology J:81238
abnormal muscle electrophysiology J:81238
abnormal neuromuscular synapse morphology J:81238
decreased body size J:81238
decreased locomotor activity J:81238
decreased motor neuron number J:81238
hypopnea J:81238
limb grasping J:81238
motor neuron degeneration J:81238
muscular atrophy J:81238
neuronal intranuclear inclusions J:81238
poor grooming J:81238
premature death J:81238
reduced fertility J:81238
weight loss J:81238
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * FVB/N 		abnormal lumbar dorsal root ganglion morphology J:131663
decreased motor neuron number J:131663
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/Tg(SMN1*A2G)2023Ahmb
Grm7Tg(SMN2)89Ahmb/?
involves: 129P2/OlaHsd * FVB/N 		abnormal motor nerve collateral sprouting J:81238
Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1-SMN2*)16Cll/0
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal neuromuscular synapse morphology J:194969
normal behavior/neurological phenotype J:194969
cardiac interstitial fibrosis J:194969
decreased body size J:194969
decreased grip strength J:194969
decreased skeletal muscle fiber size J:194969
epidermal necrosis J:194969
impaired coordination J:194969
impaired righting response J:194969
premature death J:194969
thin interventricular septum J:194969
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory