About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Foxc1
forkhead box C1
MGI:1347466
213 phenotypes from 5 alleles in 15 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Foxc1ch/Foxc1+
CHMU/Le
abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal ciliary process morphology J:61775
abnormal iridocorneal angle J:61775
abnormal trabecular meshwork morphology J:61775
absent Schlemm's canal J:61775
anterior iris synechia J:61775
cataract J:61775
ciliary body hypoplasia J:61775
corneal vascularization J:61775
mydriasis J:61775
normal vision/eye phenotype J:61775
Foxc1ch/Foxc1+
involves: C57BL/6 * CHMU/Le
bifid ureter J:60834
duplex kidney J:60834
Foxc1ch/Foxc1+
involves: CBA * STOCK Tyrc f
abnormal cervical atlas morphology J:5191
abnormal foramen magnum morphology J:5191
abnormal kidney vasculature morphology J:5191
abnormal renal/urinary system morphology J:5191
abnormal reproductive system morphology J:5191
abnormal right renal artery morphology J:5191
abnormal sternum morphology J:5191
abnormal thyroid cartilage morphology J:5191
ectopic ovary J:5191
ectopic testis J:5191
hydronephrosis J:5191
hydroureter J:5191
normal nervous system phenotype J:5191
Foxc1ch/Foxc1ch
CHMU/LeJ
abnormal sternocostal joint morphology J:221866
abnormal vertebrae development J:221866
decreased fetal size J:221866
delayed endochondral bone ossification J:221866
failure of sternum ossification J:221866
increased width of hypertrophic chondrocyte zone J:221866
short limbs J:221866
Foxc1ch/Foxc1ch
involves: C57BL/6 * CHMU/Le
abnormal mesonephros morphology J:60834
abnormal Wolffian duct morphology J:60834
bifid ureter J:60834
blind ureter J:60834
duplex kidney J:60834
ectopic ovary J:60834
ectopic testis J:60834
ectopic ureter J:60834
ectopic ureteric bud J:60834
hydroureter J:60834
Foxc1ch/Foxc1ch
involves: CBA * STOCK Tyrc f
abnormal arytenoid cartilage morphology J:14980
abnormal axial skeleton morphology J:14980
abnormal brain development J:5191, J:75733
abnormal brain ventricular system morphology J:75733
abnormal carpal bone morphology J:14980
abnormal cartilage development J:14980, J:75733
abnormal cartilage morphology J:75733
abnormal cerebellum development J:5191
abnormal cerebral aqueduct morphology J:75733
abnormal cerebral cortex morphology J:75733
abnormal cervical vertebrae morphology J:14980
abnormal choroid plexus morphology J:75733
abnormal craniofacial bone morphology J:14980
abnormal craniofacial development J:14980, J:75733
abnormal cricoid cartilage morphology J:14980
abnormal femur morphology J:14980
abnormal fibula morphology J:14980
abnormal forebrain development J:5191
abnormal fourth ventricle morphology J:75733
abnormal hindlimb morphology J:14980
abnormal hyoid bone morphology J:14980
abnormal kidney arterial blood vessel morphology J:5191
abnormal kidney development J:5191
abnormal kidney morphology J:5191
abnormal kidney venous blood vessel morphology J:5191
abnormal laryngeal cartilage morphology J:14980
abnormal lateral ventricle morphology J:75733
abnormal limb bone morphology J:14980
abnormal mesonephros morphology J:5191
abnormal metacarpal bone morphology J:14980
abnormal metanephros morphology J:5191
abnormal metatarsal bone morphology J:14980
abnormal nasal capsule morphology J:75733
abnormal nervous system development J:5191
abnormal neurocranium morphology J:14980, J:75733
abnormal notochord morphology J:75733
abnormal occipital bone morphology J:14980
abnormal patella morphology J:14980
abnormal phalanx morphology J:14980
abnormal pituitary diverticulum morphology J:5191
abnormal pituitary gland development J:75733
abnormal Reichert's cartilage morphology J:14980
abnormal rib development J:14980
abnormal rib morphology J:14980
abnormal roof plate morphology J:5191
abnormal scapula morphology J:14980
abnormal skeleton development J:14980
abnormal sphenoid bone morphology J:14980
abnormal spinal cord morphology J:5191
abnormal sternebra morphology J:14980
abnormal sternum morphology J:14980
abnormal sternum ossification J:5191
abnormal striatum morphology J:75733
abnormal tarsal bone morphology J:14980
abnormal third ventricle morphology J:75733
abnormal thyroid cartilage morphology J:14980
abnormal tibia morphology J:14980
abnormal tracheal cartilage morphology J:14980
abnormal trigeminal ganglion morphology J:75733
abnormal triquetrum morphology J:14980
abnormal ureter development J:5191
abnormal urogenital fold morphology J:5191
abnormal vertebrae development J:14980
abnormal vertebral arch morphology J:14980
abnormal vertebral transverse process morphology J:14980
abnormal vibrissa number J:75733
abnormal Wolffian duct morphology J:5191
abnormal xiphoid process morphology J:14980
absent epiglottis J:14980
absent frontal bone J:14980
absent sesamoid bone of gastrocnemius J:14980
absent sternum body J:14980
delayed bone ossification J:75733
delayed endochondral bone ossification J:14980
dilated lateral ventricle J:75733
duplex kidney J:5191
ectopic ovary J:5191
ectopic testis J:5191
enlarged kidney J:5191
enlarged maxillary zygomatic process J:14980
eyelids open at birth J:75733
failure of endochondral bone ossification J:14980
failure of intramembranous bone ossification J:14980
failure of sternum ossification J:14980
fused carpal bones J:14980
fused tarsal bones J:14980
hydronephrosis J:5191
hydroureter J:5191
intracranial hemorrhage J:5191, J:75733
neonatal lethality, complete penetrance J:75733
non-obstructive hydrocephaly J:75733
respiratory failure J:75733
short basicranium J:14980, J:75733
short humerus J:14980
short mandible J:75733
short radius J:14980
short snout J:75733
short ulna J:14980
small Meckel's cartilage J:75733
Foxc1hith/Foxc1hith
involves: C57BL/6J
abnormal brain meninges morphology J:157301
abnormal cerebral cortex morphology J:157301
abnormal forebrain morphology J:157301
abnormal neuron differentiation J:157301
abnormal neuron proliferation J:157301
abnormal stratification in cerebral cortex J:157301
Foxc1hith/Foxc1hith
involves: C57BL/6J * FVB/N
abnormal basement membrane morphology J:136459
abnormal cerebral cortex morphology J:136459
abnormal cortical marginal zone morphology J:136459
abnormal eye morphology J:136459
abnormal frontal bone morphology J:136459
abnormal hippocampus morphology J:136459
abnormal iris morphology J:136459
abnormal lens morphology J:136459
abnormal meninges morphology J:136459
abnormal neocortex morphology J:136459
abnormal radial glial cell morphology J:136459
absent corpus callosum J:136459
absent eye anterior chamber J:136459
ectopic neuron J:136459
hydrocephaly J:136459
increased cornea thickness J:136459
microphthalmia J:136459
radial glial endfoot detachment J:136459
Foxc1hith/Foxc1hith
Tg(Rr291-lacZ)#Mekk/0
involves: C57BL/6J * FVB/N
abnormal cerebral cortex morphology J:136795
Foxc1hith/Foxc1tm1Blh
involves: 129S6/SvEvTac * C57BL/6J
abnormal brain meninges morphology J:157301
abnormal cerebral cortex morphology J:157301
abnormal forebrain morphology J:157301
abnormal neuron differentiation J:157301
abnormal neuron proliferation J:157301
abnormal stratification in cerebral cortex J:157301
Foxc1tm1.1Tsku/Foxc1tm1.1Tsku
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL * Tac:NIHBS
abnormal eye morphology J:188816
absent eye anterior chamber J:188816
hydrocephaly J:188816
increased cornea thickness J:188816
Foxc1tm1Blh/Foxc1+
129S6/SvEvTac-Foxc1tm1Blh
abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal cornea morphology J:61775
abnormal iridocorneal angle J:61775
abnormal placement of pupils J:61775
abnormal trabecular meshwork morphology J:61775
irregularly shaped pupil J:61775
Foxc1tm1Blh/Foxc1+
B6.Cg-Foxc1tm1Blh
abnormal aqueous drainage system morphology J:82280
hypoplastic trabecular meshwork J:82280
Foxc1tm1Blh/Foxc1+
involves: 129S6/SvEvTac * Black Swiss
abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal iridocorneal angle J:61775
abnormal iris morphology J:61775
abnormal iris pigment epithelium J:61775
abnormal placement of pupils J:61775
abnormal trabecular meshwork morphology J:61775
iris hypoplasia J:61775
iris stroma hypoplasia J:61775
irregularly shaped pupil J:61775
Foxc1tm1Blh/Foxc1+
involves: 129S6/SvEvTac * C57BL/6J
abnormal anterior eye segment morphology J:61775
abnormal canal of Schlemm morphology J:61775
abnormal cornea morphology J:61775
abnormal iridocorneal angle J:61775
abnormal iris morphology J:61775
abnormal line of Schwalbe morphology J:61775
abnormal placement of pupils J:61775
abnormal trabecular meshwork morphology J:61775
anterior iris synechia J:61775
cataract J:61775
irregularly shaped pupil J:61775
normal vision/eye phenotype J:61775
Foxc1tm1Blh/Foxc1+
involves: 129S6/SvEvTac * CAST/Ei
abnormal canal of Schlemm morphology J:61775
abnormal iridocorneal angle J:61775
abnormal trabecular meshwork morphology J:61775
normal vision/eye phenotype J:61775
Foxc1tm1Blh/Foxc1tm1Blh
involves: 129S6/SvEvTac
abnormal brain meninges morphology J:157301
abnormal cerebral cortex morphology J:157301
abnormal forebrain morphology J:157301
abnormal neuron differentiation J:157301
abnormal neuron proliferation J:157301
abnormal stratification in cerebral cortex J:157301
normal embryo phenotype J:91443
Foxc1tm1Blh/Foxc1tm1Blh
involves: 129S6/SvEvTac * Black Swiss
abnormal aortic valve cusp morphology J:57677
abnormal aortic valve morphology J:57677
abnormal bone ossification J:48079
abnormal cornea morphology J:48079
abnormal corneal endothelium morphology J:56425
abnormal corneal epithelium morphology J:56425
abnormal craniofacial bone morphology J:48079
abnormal deltoid tuberosity morphology J:48079
abnormal exorbital lacrimal gland morphology J:107208
abnormal fourth pharyngeal arch artery morphology J:57677
abnormal humerus morphology J:48079
abnormal lacrimal gland branching morphogenesis J:107208
abnormal lacrimal gland morphology J:107208
abnormal lacrimal gland physiology J:107208
abnormal maxillary zygomatic process morphology J:48079
abnormal mesonephros morphology J:105944
abnormal nasolacrimal duct morphology J:107208
abnormal ovarian bursa morphology J:105944
abnormal ovarian cortex morphology J:105944
abnormal ovarian follicle morphology J:105944
abnormal ovarian medulla morphology J:105944
abnormal ovary morphology J:105944
abnormal oviduct morphology J:105944
abnormal pharyngeal arch artery morphology J:57677
abnormal primordial germ cell migration J:105944
abnormal pulmonary valve cusp morphology J:57677
abnormal pulmonary valve morphology J:57677
abnormal semilunar valve morphology J:57677
abnormal skeleton morphology J:48079
abnormal sternum ossification J:48079
abnormal tarsal bone morphology J:48079
abnormal testis tunica albuginea morphology J:105944
abnormal vertebral arch morphology J:48079
abnormal xiphoid process morphology J:48079
absent intraorbital lacrimal gland J:107208
absent neurocranium J:48079
absent sternum J:57677
aortic arch coarctation J:57677
bifid ureter J:60834
decreased oocyte number J:105944
disorganized testis cords J:105944
duplex kidney J:60834
enlarged maxillary zygomatic process J:48079
eyelids open at birth J:48079
hydrocephaly J:48079
hydrops fetalis J:57677
impaired ovarian folliculogenesis J:105944
increased corneal epithelium thickness J:56425
interrupted aortic arch J:57677
intracranial hemorrhage J:48079
iris hypoplasia J:48079
neonatal lethality, complete penetrance J:48079, J:57677, J:105944
oocyte degeneration J:105944
ovary cyst J:105944
ovary hemorrhage J:105944
patent ductus arteriosus J:57677
polyovular ovarian follicle J:105944
short oviduct J:105944
small basisphenoid bone J:48079
small gonad J:105944
small lens J:56425
small ovary J:105944
small testis J:105944
small vertebral body J:48079
thick aortic valve cusps J:57677
thick pulmonary valve cusps J:57677
thin ribs J:48079
ventricular septal defect J:57677
Foxc1tm1Tsku/Foxc1tm1Blh
Tg(Tek-cre)1Rwng/0
involves: 129S6/SvEvTac * FVB/N
abnormal cell migration J:131323
Foxc1tm1Tsku/Foxc1tm1Tsku
involves: 129S6/SvEvTac * C57BL/6 * NIH Black Swiss * SJL
no abnormal phenotype detected J:188816

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory