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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mapk3
mitogen-activated protein kinase 3
MGI:1346859
36 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Krastm1Bbd/Kras+
Mapk3tm1Gpg/Mapk3tm1Gpg
involves: 129/Sv * 129S1/Sv * 129X1/SvJ 		increased lung non-small cell carcinoma incidence J:172200
premature death J:172200
Krastm1Bbd/Kras+
Mapk1tm1.1Hed/Mapk1tm1.1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
involves: 129/Sv * 129S1/Sv * 129X1/SvJ 		decreased classified tumor incidence J:172200
premature death J:172200
Mapk1tm1.1Hed/Mapk1tm1.1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129 		premature death J:172200
Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal eye distance/ position J:144862
abnormal thymus morphology J:144862
abnormal thyroid gland morphology J:144862
absent tongue J:144862
cleft palate J:144862
mandible hypoplasia J:144862
persistent truncus arteriosus J:144862
short maxilla J:144862
ventricular septal defect J:144862
Mapk1tm1Gela/Mapk1tm1Gela
Mapk3tm1Gela/Mapk3tm1Gela
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal eye distance/ position J:144862
abnormal thyroid gland morphology J:144862
absent mandible J:144862
absent outer ear J:144862
absent tongue J:144862
athymia J:144862
decreased body length J:144862
persistent truncus arteriosus J:144862
short maxilla J:144862
small pharyngeal arch J:144862
ventricular septal defect J:144862
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Cd4-cre)1Cwi/0
involves: 129/Sv * C57BL/6 * DBA/2 		abnormal positive T cell selection J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Cd4-cre)1Cwi/0
Tg(TcrAND)53Hed/0
involves: 129/Sv * C57BL/6 * DBA/2 * SJL 		abnormal positive T cell selection J:113280
abnormal T cell subpopulation ratio J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Lck-cre)1Cwi/0
involves: 129/Sv * C57BL/6 * DBA/2 		abnormal T cell proliferation J:113280
decreased thymocyte number J:113280
increased double-positive T cell number J:113280
small thymus J:113280
Mapk1tm1Hed/Mapk1tm1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(TcraTcrb)1100Mjb/0
involves: 129/Sv * C57BL/6 		decreased thymocyte number J:113280
Mapk1tm2Melo/Mapk1tm2Melo
Mapk3tm1Gpg/Mapk3tm1Gpg
involves: 129 		abnormal mitosis J:162580
early cellular replicative senescence J:162580
increased fibroblast apoptosis J:162580
Mapk1tm2Moga/Mapk1tm2Moga
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Mx1-cre)1Cgn/?
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA 		abnormal pro-B cell differentiation J:134528
abnormal pro-B cell morphology J:134528
decreased pre-B cell number J:134528
Mapk3tm1Gpg/Mapk3+
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129/Sv * C3H * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:142212
hepatic necrosis J:142212
increased atrioventricular cushion size J:142212
nuchal edema J:142212
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0
Tg(Tek-cre)12Flv/0
involves: 129/Sv * C3H * C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:142212
embryonic lethality during organogenesis, complete penetrance J:142212
hepatic necrosis J:142212
nuchal edema J:142212
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Myh6-Map2k1*)1Jmol/0
involves: 129/Sv * FVB/N 		cardiac hypertrophy J:124903
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Myh7-Ptpn11*Q79R)11Rbns/0
involves: 129/Sv * FVB/N 		normal cardiovascular system phenotype J:123963
normal respiratory system phenotype J:123963
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory