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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sh3bp2
SH3-domain binding protein 2
MGI:1346349
12 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Csf1op/Csf1op
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
involves: 129S4/SvJae * BALB/cJ * C57BL/6J 		abnormal lymph node cell ratio J:117880
increased circulating tumor necrosis factor level J:117880
liver inflammation J:117880
normal skeleton phenotype J:117880
Myd88tm1Aki/Myd88tm1Aki
Sh3bp2tm1.1Ics/Sh3bp2tm1.1Ics
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:221901
Nfatc1tm3Glm/Nfatc1tm3Glm
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal osteoclast differentiation J:144598
decreased osteoclast cell number J:144598
liver inflammation J:144598
lung inflammation J:144598
lymph node inflammation J:144598
normal skeleton phenotype J:144598
stomach inflammation J:144598
Rag1tm1Mom/Rag1tm1Mom
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J 		abnormal osteoclast differentiation J:117880
decreased bone mineral density J:117880
increased circulating tumor necrosis factor level J:117880
increased inflammatory response J:117880
Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl
Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N 		normal skeleton phenotype J:243612
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J 		abnormal osteoclast differentiation J:117880
normal immune system phenotype J:117880
normal skeleton phenotype J:117880
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory