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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nr0b2
nuclear receptor subfamily 0, group B, member 2
MGI:1346344
22 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nr0b2tm1.1Auw/Nr0b2tm1.1Auw
involves: 129S2/SvPas * C57BL/6J 		abnormal testis physiology J:118368
decreased testis weight J:118368
early sexual maturation J:118368
increased circulating testosterone level J:118368
increased epididymis weight J:118368
small testis J:118368
Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
involves: 129S/SvEvBrd * 129S4/SvJae 		decreased circulating cholesterol level J:149005
decreased circulating HDL cholesterol level J:149005
decreased circulating LDL cholesterol level J:149005
decreased circulating VLDL cholesterol level J:149005
normal homeostasis/metabolism phenotype J:149005
Nr0b2tm1Auw/Nr0b2tm1Auw
involves: 129S2/SvPas * C57BL/6J 		no abnormal phenotype detected J:118368
Nr0b2tm1Ddm/Nr0b2tm1Ddm
involves: 129 * C57BL/6 		abnormal bile salt homeostasis J:77065
abnormal bile salt level J:77065
decreased circulating cholesterol level J:77065
increased bile salt level J:77065
increased liver triglyceride level J:77065
increased susceptibility to weight loss J:77065
Nr0b2tm1Mjev/Nr0b2tm1Mjev
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S/SvEvBrd * C57BL/6 * DBA 		decreased circulating cholesterol level J:149005
decreased circulating LDL cholesterol level J:149005
Nr0b2tm1Rus/Nr0b2tm1Rus
involves: 129P2/OlaHsd * C57BL/6 		abnormal bile salt homeostasis J:102129
abnormal bile salt level J:102129
abnormal lipid homeostasis J:102129
abnormal liver physiology J:102129
increased circulating alanine transaminase level J:102129
increased circulating aspartate transaminase level J:102129
increased intestinal cholesterol absorption J:102129
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory