Tlr2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tlr2
toll-like receptor 2
MGI:1346060

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ldlr^tm1Her/Ldlr^tm1Her Tlr2^tm1Kir/Tlr2^tm1Kir B6.129-Tlr2^tm1Kir Ldlr^tm1Her	abnormal cellular extravasation	J:131783
	atherosclerotic lesions	J:102502, J:131783
	decreased circulating cholesterol level	J:102502
	decreased tumor necrosis factor secretion	J:131783
	increased body weight	J:102502, J:131783
Tlr2^tm1Aki/Tlr2^tm1Aki Tlr4^tm1Aki/Tlr4^tm1Aki B6.129P2-Tlr2^tm1Aki Tlr4^tm1Aki	abnormal chemokine secretion	J:102879
	abnormal lung interstitium morphology	J:102879
	hyperoxia	J:102879
	increased apoptosis	J:102879
	increased physiological sensitivity to xenobiotic	J:102879
Tlr2^tm1Aki/Tlr2^tm1Aki Tlr4^tm1Aki/Tlr4^tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal cytokine secretion	J:117688
	abnormal macrophage physiology	J:117688
	decreased IgG3 level	J:117688
Tlr2^tm1Aki/Tlr2^tm1Aki Tlr6^tm1Aki/Tlr6^tm1Aki involves: 129P2/OlaHsd * C57BL/6	decreased interleukin-6 secretion	J:70578
Tlr2^tm1Kir/Tlr2^tm1Kir Tg(APP695)3Dbo/? Tg(PSEN1)5Dbo/? involves: 129 * C3H/HeJ * C57BL/6	abnormal long-term spatial reference memory	J:136387
	amyloid beta deposits	J:136387
	impaired passive avoidance behavior	J:136387
Tlr2^tm1Kir/Tlr2^tm1Kir Tlr4^Lps-d/Tlr4^Lps-d C3.Cg-Tlr2^tm1Kir Tlr4^Lps-d	abnormal macrophage physiology	J:121930
	decreased susceptibility to induced morbidity/mortality	J:121930
Tlr2^tm1Kir/Tlr2^tm1Kir Tlr4^tm1Aki/Tlr4^tm1Aki B6.129-Tlr2^tm1Kir Tlr4^tm1Aki	decreased susceptibility to induced morbidity/mortality	J:121930

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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