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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tlr2
toll-like receptor 2
MGI:1346060
18 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Ldlrtm1Her/Ldlrtm1Her
Tlr2tm1Kir/Tlr2tm1Kir
B6.129-Tlr2tm1Kir Ldlrtm1Her
abnormal cellular extravasation J:131783
atherosclerotic lesions J:102502, J:131783
decreased circulating cholesterol level J:102502
decreased tumor necrosis factor secretion J:131783
increased body weight J:102502, J:131783
Tlr2tm1Aki/Tlr2tm1Aki
Tlr4tm1Aki/Tlr4tm1Aki
B6.129P2-Tlr2tm1Aki Tlr4tm1Aki
abnormal chemokine secretion J:102879
abnormal lung interstitium morphology J:102879
hyperoxia J:102879
increased apoptosis J:102879
increased physiological sensitivity to xenobiotic J:102879
Tlr2tm1Aki/Tlr2tm1Aki
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6
abnormal cytokine secretion J:117688
abnormal macrophage physiology J:117688
decreased IgG3 level J:117688
Tlr2tm1Aki/Tlr2tm1Aki
Tlr6tm1Aki/Tlr6tm1Aki
involves: 129P2/OlaHsd * C57BL/6
decreased interleukin-6 secretion J:70578
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
involves: 129 * C3H/HeJ * C57BL/6
abnormal long term spatial reference memory J:136387
amyloid beta deposits J:136387
impaired passive avoidance behavior J:136387
Tlr2tm1Kir/Tlr2tm1Kir
Tlr4Lps-d/Tlr4Lps-d
C3.Cg-Tlr2tm1Kir Tlr4Lps-d
abnormal macrophage physiology J:121930
decreased sensitivity to induced morbidity/mortality J:121930
Tlr2tm1Kir/Tlr2tm1Kir
Tlr4tm1Aki/Tlr4tm1Aki
B6.129-Tlr2tm1Kir Tlr4tm1Aki
decreased sensitivity to induced morbidity/mortality J:121930

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory