Klk8 Phenotype Annotations

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klk8
kallikrein related-peptidase 8
MGI:1343327

17 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Klk8^{em1(IMPC)Ccpcz}/Klk8^{em1(IMPC)Ccpcz} C57BL/6N-Klk8^{em1(IMPC)Ccpcz}/Ccpcz	abnormal kidney morphology	J:211773
	abnormal spleen morphology	J:211773
	decreased lymphocyte cell number	J:211773
	enlarged spleen	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Klk8^tm1Lth/Klk8^tm1Lth involves: 129P2/OlaHsd * C57BL/6	abnormal excitatory postsynaptic potential	J:71533
	normal behavior/neurological phenotype	J:71533
	increased susceptibility to pharmacologically induced seizures	J:71533
	increased susceptibility to xenobiotic induced morbidity/mortality	J:71533
	normal nervous system phenotype	J:71533
Klk8^tm1Shio/Klk8^tm1Shio involves: 129P2/OlaHsd * C57BL/6J	abnormal brain interneuron morphology	J:68653
	abnormal GABAergic neuron morphology	J:68653
	abnormal hippocampus morphology	J:68653
	abnormal hippocampus pyramidal cell layer	J:68653
	abnormal hippocampus pyramidal cell morphology	J:68653
	abnormal synaptic bouton morphology	J:68653
	decreased CNS synapse formation	J:68653
	normal nervous system phenotype	J:68653

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23