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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hdac3
histone deacetylase 3
MGI:1343091
58 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Hdac3tm1.1Eno/Hdac3tm1.1Eno
Pgrtm2(cre)Lyd/Pgr+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal decidualization J:269518
abnormal embryo attachment J:269518
abnormal endometrium morphology J:269518
abnormal uterine receptivity J:269518
abnormal uterus physiology J:269518
endometrium fibrosis J:269518
failure of embryo implantation J:269518
female infertility J:269518
normal homeostasis/metabolism phenotype J:269518
increased collagen level J:269518
normal reproductive system phenotype J:269518
Hdac3tm1.1Eno/Hdac3tm1.1Eno
Tg(Myh6-cre)2182Mds/?
involves: 129S/SvEv * C57BL/6
abnormal cellular respiration J:144604
abnormal heart morphology J:144604
abnormal heart size J:144604
abnormal lipid level J:144604
abnormal mitochondrial crista morphology J:144604
abnormal myocardial fiber mitochondrial morphology J:144604
cardiac hypertrophy J:144604
cardiac interstitial fibrosis J:144604
normal cardiovascular system phenotype J:144604
decreased ventricle muscle contractility J:144604
dilated heart left ventricle J:144604
increased cardiac muscle triglyceride level J:144604
increased heart weight J:144604
premature death J:144604
Hdac3tm1.1Laz/Hdac3tm1.1Laz
C57BL/6-Hdac3tm1.1Laz
enhanced long-term object recognition memory J:168224
Hdac3tm1.1Laz/Hdac3tm1.1Laz
involves: C57BL/6
hepatic steatosis J:206152
Hdac3tm1.1Laz/Hdac3tm1.1Laz
Tg(Adipoq-cre)1Evdr/0
involves: C57BL/6 * FVB
normal mortality/aging J:199860
Hdac3tm1.1Laz/Hdac3tm1.1Laz
Tg(Fabp4-cre)1Rev/0
involves: C57BL/6
cachexia J:199860
postnatal lethality, incomplete penetrance J:199860
premature death J:199860
Hdac3tm1.1Laz/Hdac3tm1.1Laz
Tg(Retn-cre)1Laz/0
involves: C57BL/6
no abnormal phenotype detected J:199860
Hdac3tm1.1Swh/Hdac3tm1.1Swh
involves: 129S6/SvEvTac * FVB/N
embryonic lethality, complete penetrance J:134665
Hdac3tm1.2Eno/Hdac3tm1.2Eno
involves: 129S/SvEv * C57BL/6
abnormal gastrulation J:144604
embryonic lethality, complete penetrance J:144604
Hdac3tm1a(EUCOMM)Wtsi/Hdac3tm1a(EUCOMM)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Hdac3tm1a(EUCOMM)Wtsi/Wtsi
preweaning lethality, complete penetrance J:211773
Hdac3tm1Swh/Hdac3tm1.1Swh
involves: 129S6/SvEvTac * FVB/N
abnormal cell cycle J:134665
abnormal cell death J:134665
abnormal cell physiology J:134665
decreased cell proliferation J:134665
Hdac3tm1Swh/Hdac3tm1.1Swh
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac * C57BL/6 * DBA
abnormal glucose homeostasis J:134288
abnormal hepatocyte morphology J:134288
decreased body size J:134288
decreased circulating glucagon level J:134288
decreased circulating insulin level J:134288
decreased liver glycogen level J:134288
decreased total body fat amount J:134288
enlarged liver J:134288
hepatic steatosis J:134288
hypoglycemia J:134288
increased cholesterol level J:134288
increased circulating alanine transaminase level J:134288
increased circulating cholesterol level J:134288
increased circulating LDL cholesterol level J:134288
increased circulating triglyceride level J:134288
increased hepatocyte proliferation J:134288
increased liver triglyceride level J:134288
increased liver weight J:134288
normal mortality/aging J:134288
pale liver J:134288
Hdac3tm1Swh/Hdac3tm1.1Swh
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
abnormal cell cycle J:134665
abnormal DNA repair J:134665
increased fibroblast apoptosis J:134665
Hdac3tm1Swh/Hdac3tm1.1Swh
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA
abnormal hepatocyte morphology J:134288
decreased liver glycogen level J:134288
enlarged liver J:134288
hepatic steatosis J:134288
increased liver weight J:134288

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory