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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
MGI:1342774
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ay/a
Tg(tetO-Ppargc1a)1Dpk/0
Tg(Tyr-rtTA)37Lc/0
involves: FVB 		abnormal hair follicle melanogenesis J:194191
darkened coat color J:194191
Htttm1Mfc/Htt+
Ppargc1atm1Dpk/Ppargc1a+
involves: 129S1/Sv * 129X1/SvJ 		abnormal striatum morphology J:116058
impaired coordination J:116058
neuron degeneration J:116058
Mirc33tm1.1Wtsi/Mirc33tm1.1Wtsi
Ppargc1atm1Brsp/Ppargc1a+
involves: 129S4/SvJae * C57BL/6N 		normal cardiovascular system phenotype J:267719
decreased mitochondrial size J:267719
premature death J:267719
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1.1Dpk/Ppargc1b+
involves: 129X1/SvJ * FVB/N 		impaired adaptive thermogenesis J:137598
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
involves: 129X1/SvJ * FVB/N 		abnormal blood circulation J:137598
abnormal brown adipose tissue morphology J:137598
abnormal fat cell morphology J:137598
abnormal heart development J:137598
abnormal heart left ventricle morphology J:137598
abnormal myocardium layer morphology J:137598
abnormal pulmonary alveolus morphology J:137598
congestive heart failure J:137598
decreased body weight J:137598
decreased cardiac output J:137598
decreased circulating glucose level J:137598
decreased heart left ventricle weight J:137598
decreased heart rate J:137598
decreased triglyceride level J:137598
neonatal lethality, incomplete penetrance J:137598
postnatal lethality, complete penetrance J:137598
respiratory distress J:137598
small heart J:137598
Ppargc1atm1Dpk/Ppargc1atm1Dpk
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Myh6-cre)2182Mds/0
involves: 129X1/SvJ * FVB/N 		abnormal myocardium layer morphology J:137598
decreased cardiac output J:137598
neonatal lethality, incomplete penetrance J:137598
postnatal lethality, complete penetrance J:137598
Ppargc1atm2Brsp/Ppargc1atm2Brsp
Ppargc1btm1Dpk/Ppargc1btm1Dpk
Tg(Tyr-cre)1Lru/0
involves: 129 * 129X1/SvJ * C57BL/6 		normal pigmentation phenotype J:194191
Surf1tm1Zev/Surf1tm1Zev
Tg(Ckm-Ppargc1a)31Brsp/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal aerobic respiration J:176080
increased mitochondrial fission J:176080
Tg(Ckm-Ppargc1a)31Brsp/0
C57BL/6-Tg(Ckm-Ppargc1a)31Brsp 		abnormal depression-related behavior J:213551
abnormal muscle physiology J:78333
abnormal skeletal muscle morphology J:78333
Tg(Ckm-Ppargc1a)31Brsp/0
C57BL/6-Tg(Ckm-Ppargc1a)31Brsp/J 		abnormal aerobic respiration J:176080
increased mitochondrial fission J:176080
Tg(Myh6-rtTA)8585Jam/0
Tg(tetO-Ppargc1a)1Dpk/0
involves: FVB/N * FVB/NTac 		abnormal heart left ventricle morphology J:96614
abnormal mitochondrial morphology J:96614
abnormal myocardial fiber morphology J:96614
cardiac hypertrophy J:96614
cardiomyopathy J:96614
decreased cardiac muscle contractility J:96614
decreased heart rate J:96614
dilated heart left ventricle J:96614
dilated heart right ventricle J:96614
increased heart rate J:96614
increased mitochondrial fission J:96614
Tg(Myog-Ppargc1a_i4)#Brsp/0
Not Specified 		decreased body fat mass J:211329
decreased epididymal fat pad weight J:211329
decreased subcutaneous adipose tissue amount J:211329
decreased susceptibility to diet-induced obesity J:211329
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory