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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Klf1
Kruppel-like transcription factor 1 (erythroid)
MGI:1342771
28 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Klf1Nan/Klf1+
either: B6.Cg-Klf1Nan or WB.Cg-Klf1Nan
abnormal erythrocyte morphology J:162530
anisocytosis J:162530
decreased erythrocyte cell number J:162530
decreased hematocrit J:162530
decreased hemoglobin content J:162530
decreased mean corpuscular hemoglobin J:162530
increased erythrocyte osmotic fragility J:162530
increased spleen weight J:162530
pallor J:162530
poikilocytosis J:162530
polychromatophilia J:162530
postnatal lethality, incomplete penetrance J:162530
Klf1Nan/Klf1+
involves: 101/H * C3H/HeH * PT
abnormal proximal convoluted tubule morphology J:13933
anemia J:13933
anisocytosis J:13933
decreased erythrocyte cell number J:13933
enlarged spleen J:13933
increased kidney iron level J:13933
increased liver iron level J:13933
increased nucleated erythrocyte cell number J:13933
increased spleen iron level J:13933
Klf1Nan/Klf1Nan
involves: 101/H * C3H/HeH * PT
embryonic lethality during organogenesis, complete penetrance J:13933
impaired hematopoiesis J:13933
Klf1tm1.1Ryan/Klf1tm1.1Ryan
involves: 129S4/SvJae * C57BL/6 * C57BL/6J
normal hematopoietic system phenotype J:204029
Klf1tm1Nimr/Klf1tm1Nimr
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)
abnormal erythropoiesis J:25650
anemia J:25650
decreased hemoglobin content J:25650
embryonic lethality during organogenesis, complete penetrance J:25650
erythroblastosis J:25650
impaired hematopoiesis J:25650
pale liver J:25650
small liver J:25650
Klf1tm1Sho/Klf1tm1Sho
involves: 129S4/SvJae * C57BL/6
abnormal embryonic erythrocyte morphology J:25651
abnormal erythrocyte morphology J:25651
abnormal erythropoiesis J:25651
anemia J:25651
lethality throughout fetal growth and development, complete penetrance J:25651

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory