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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ikzf1
IKAROS family zinc finger 1
MGI:1342540
127 phenotypes from 11 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd79atm1(cre)Reth/Cd79a+
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL 		abnormal B cell differentiation J:209928
abnormal B cell number J:209928
decreased pre-B cell number J:209928
increased pro-B cell number J:209928
normal neoplasm J:209928
Ikzf1m1Btlr/Ikzf1m1Btlr
C57BL/6J-Ikzf1m1Btlr 		abnormal natural killer cell mediated cytotoxicity J:265249
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:265249
decreased CD8-positive, naive alpha-beta T cell number J:265249
decreased heart rate J:265249
enhanced humoral immune response J:265249
increased B-1 B cell number J:265249
increased CD4-positive, alpha-beta T cell number J:265249
increased CD8-positive, alpha-beta T cell number J:265249
increased central memory CD4-positive, alpha-beta T cell number J:265249
increased central memory CD8 positive, alpha-beta T cell number J:265249
increased effector memory CD4-positive, alpha-beta T cell number J:265249
increased IgG level J:265249
increased response to antigen J:265249
increased single-positive T cell number J:265249
increased T cell number J:265249
Ikzf1m2Btlr/Ikzf1m2Btlr
C57BL/6J-Ikzf1m2Btlr 		decreased B cell number J:265250
decreased CD4-positive, alpha-beta T cell number J:265250
decreased CD8-positive, naive alpha-beta T cell number J:265250
decreased heart rate J:265250
decreased single-positive T cell number J:265250
decreased T cell number J:265250
increased CD8-positive, alpha-beta T cell number J:265250
increased central memory CD4-positive, alpha-beta T cell number J:265250
increased central memory CD8 positive, alpha-beta T cell number J:265250
increased effector memory CD4-positive, alpha-beta T cell number J:265250
increased effector memory CD8-positive, alpha-beta T cell number J:265250
increased single-positive T cell number J:265250
Ikzf1m3Btlr/Ikzf1m3Btlr
C57BL/6J-Ikzf1m3Btlr 		decreased CD4-positive, alpha-beta T cell number J:265251
increased B-1 B cell number J:265251
increased CD8-positive, alpha-beta T cell number J:265251
increased single-positive T cell number J:265251
increased T cell number J:265251
Ikzf1plstc/Ikzf1+
C57BL/6JSfdAnu-Ikzf1plstc 		abnormal B cell differentiation J:84569
abnormal lymphopoiesis J:84569
abnormal T cell differentiation J:84569
decreased double-negative T cell number J:84569
decreased double-positive T cell number J:84569
decreased mature B cell number J:84569
decreased pre-B cell number J:84569
decreased thymocyte number J:84569
increased leukemia incidence J:84569
increased pro-B cell number J:84569
increased T cell derived lymphoma incidence J:84569
liver hypoplasia J:84569
myeloid hyperplasia J:84569
premature death J:84569
Ikzf1plstc/Ikzf1plstc
C57BL/6JSfdAnu-Ikzf1plstc 		abnormal erythroblast morphology J:84569
abnormal granulocyte differentiation J:84569
abnormal lymphopoiesis J:84569
abnormal macrophage differentiation J:84569
abnormal myelopoiesis J:84569
absent pro-B cells J:84569
absent T cells J:84569
anemia J:84569
arrested B cell differentiation J:84569
decreased erythrocyte cell number J:84569
decreased erythroid progenitor cell number J:84569
decreased fetal derived definitive erythrocyte cell number J:84569
decreased granulocyte number J:84569
decreased hematocrit J:84569
decreased hemoglobin content J:84569
increased macrophage cell number J:84569
lethality throughout fetal growth and development, complete penetrance J:84569
liver hypoplasia J:84569
pallor J:84569
reticulocytopenia J:84569
thymus hypoplasia J:84569
Ikzf1plstc/Ikzf1tm2Kge
involves: 129S4/SvJae * C57BL/6 * C57BL/6JSfdAnu 		abnormal erythropoiesis J:84569
anemia J:84569
Ikzf1tm1.1Smale/Ikzf1tm1.1Smale
B6.Cg-Ikzf1tm1.1Smale 		decreased B cell number J:208211
decreased B-1a cell number J:208211
decreased B-1b cell number J:208211
decreased DN1 thymic pro-T cell number J:208211
decreased immature B cell number J:208211
decreased mature B cell number J:208211
decreased pre-B cell number J:208211
normal immune system phenotype J:208211
normal neoplasm J:208211
thymus hypoplasia J:208211
Ikzf1tm1.1Smale/Ikzf1tm2Kge
involves: 129S4/SvJae * C57BL/6 		lethality, complete penetrance J:208211
Ikzf1tm1Kast/Ikzf1tm1Kast
involves: 129S2/SvPas 		abnormal B cell activation J:82813
abnormal B cell differentiation J:82813
decreased B cell number J:82813
decreased B cell proliferation J:82813
decreased B-1a cell number J:82813
decreased B-1b cell number J:82813
decreased IgG3 level J:82813
decreased spleen germinal center number J:82813
Ikzf1tm1Kge/Ikzf1+
involves: 129S4/SvJae * BALB/c 		abnormal lymph node cortex morphology J:29355
abnormal lymph node medulla morphology J:29355
abnormal T cell differentiation J:29355
abnormal thymocyte activation J:29355
abnormal thymus lobule morphology J:29355
abnormal thymus medulla morphology J:29355
decreased spleen red pulp amount J:29355
enlarged cervical lymph nodes J:29355
enlarged mesenteric lymph nodes J:29355
enlarged thymus J:29355
increased leukemia incidence J:29355
increased spleen white pulp amount J:29355
increased T cell proliferation J:29355
lymph node hyperplasia J:29355
premature death J:29355
spleen hyperplasia J:29355
thymus cortex hypoplasia J:29355
Ikzf1tm1Kge/Ikzf1+
involves: 129S4/SvJae * C57BL/6 		abnormal lymph node cortex morphology J:29355
abnormal lymph node medulla morphology J:29355
abnormal T cell differentiation J:29355
abnormal thymocyte activation J:29355
abnormal thymus lobule morphology J:29355
abnormal thymus medulla morphology J:29355
decreased spleen red pulp amount J:29355
enlarged cervical lymph nodes J:29355
enlarged mesenteric lymph nodes J:29355
enlarged thymus J:29355
increased leukemia incidence J:29355
increased spleen white pulp amount J:29355
increased T cell proliferation J:29355
lymph node hyperplasia J:29355
premature death J:29355
spleen hyperplasia J:29355
thymus cortex hypoplasia J:29355
Ikzf1tm1Kge/Ikzf1tm1Kge
involves: 129S4/SvJae * BALB/c 		abnormal common myeloid progenitor cell morphology J:20671
abnormal definitive hematopoiesis J:20671
abnormal eosinophil morphology J:20671
abnormal erythroid progenitor cell morphology J:20671
abnormal gut flora balance J:20671
abnormal immune system organ morphology J:20671
abnormal NK cell morphology J:20671
abnormal spleen morphology J:20671
abnormal thymus cortex morphology J:20671
abnormal thymus morphology J:20671
absent axillary lymph nodes J:20671
absent B cells J:20671
absent cervical lymph nodes J:20671
absent inguinal lymph nodes J:20671
absent mesenteric lymph nodes J:20671
absent Peyer's patches J:20671
absent pre-B cells J:20671
arrested T cell differentiation J:20671
decreased body size J:20671
decreased bone marrow cell number J:20671
decreased gamma-delta intraepithelial T cell number J:20671
enlarged spleen J:20671
extramedullary hematopoiesis J:20671
increased basophil cell number J:20671
increased nucleated erythrocyte cell number J:20671
increased susceptibility to bacterial infection J:20671
intermingled spleen red and white pulp J:20671
lung inflammation J:20671
multifocal hepatic necrosis J:20671
postnatal lethality, incomplete penetrance J:20671
thymus hypoplasia J:20671
Ikzf1tm1Kge/Ikzf1tm1Kge
involves: 129S4/SvJae * C57BL/6 		abnormal common myeloid progenitor cell morphology J:20671
abnormal definitive hematopoiesis J:20671
abnormal eosinophil morphology J:20671
abnormal erythroid progenitor cell morphology J:20671
abnormal gut flora balance J:20671
abnormal immune system organ morphology J:20671
abnormal NK cell morphology J:20671
abnormal spleen morphology J:20671
abnormal thymus cortex morphology J:20671
abnormal thymus morphology J:20671
absent axillary lymph nodes J:20671
absent B cells J:20671
absent cervical lymph nodes J:20671
absent inguinal lymph nodes J:20671
absent mesenteric lymph nodes J:20671
absent Peyer's patches J:20671
absent pre-B cells J:20671
arrested T cell differentiation J:20671
decreased body size J:20671
decreased bone marrow cell number J:20671
decreased gamma-delta intraepithelial T cell number J:20671
enlarged spleen J:20671
extramedullary hematopoiesis J:20671
increased basophil cell number J:20671
increased nucleated erythrocyte cell number J:20671
increased susceptibility to bacterial infection J:20671
intermingled spleen red and white pulp J:20671
lung inflammation J:20671
multifocal hepatic necrosis J:20671
postnatal lethality, incomplete penetrance J:20671
thymus hypoplasia J:20671
Ikzf1tm2.1Smale/Ikzf1tm2.1Smale
B6.Cg-Ikzf1tm2.1Smale 		abnormal definitive hematopoiesis J:208211
abnormal lymphopoiesis J:208211
abnormal peripheral lymph node morphology J:208211
abnormal T cell differentiation J:208211
absent inguinal lymph nodes J:208211
absent NK cells J:208211
absent Peyer's patches J:208211
decreased B cell number J:208211
decreased body size J:208211
decreased DN2 thymocyte number J:208211
decreased DN3 thymocyte number J:208211
decreased double-negative T cell number J:208211
decreased double-positive T cell number J:208211
decreased immature B cell number J:208211
decreased mature B cell number J:208211
decreased plasmacytoid dendritic cell number J:208211
decreased pre-pro B cell number J:208211
normal immune system phenotype J:208211
increased gamma-delta T cell number J:208211
increased lymphoma incidence J:208211
increased pre-B cell number J:208211
premature death J:208211
thymus cortex hypoplasia J:208211
thymus hypoplasia J:208211
Ikzf1tm2Kge/Ikzf1tm2.1Smale
involves: 129S4/SvJae * C57BL/6 		lethality, complete penetrance J:208211
Ikzf1tm2Kge/Ikzf1tm2Kge
involves: 129S4/SvJae 		abnormal dendritic cell number J:37317
abnormal erythropoiesis J:37317
abnormal splenic cell ratio J:37317
abnormal T cell differentiation J:37317, J:208211
abnormal thymus development J:37317
absent axillary lymph nodes J:37317
absent B cells J:37317, J:208211
absent B-1a cells J:37317
absent cervical lymph nodes J:37317
absent inguinal lymph nodes J:37317
absent mesenteric lymph nodes J:37317
absent NK cells J:37317, J:208211
absent Peyer's patches J:37317
absent pre-B cells J:37317
absent pro-B cells J:37317
decreased double-positive T cell number J:37317
decreased gamma-delta intraepithelial T cell number J:37317
decreased granulocyte number J:37317
decreased mature gamma-delta T cell number J:37317
decreased plasmacytoid dendritic cell number J:208211
decreased splenocyte number J:37317
increased T cell proliferation J:37317
thymus hypoplasia J:37317
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Il7rtm1.1(icre)Hrr/Il7r+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		increased T cell derived lymphoma incidence J:209928
Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD2-icre)4Kio/?
involves: C57BL/10 * CBA/Ca 		abnormal B cell physiology J:209927
increased T cell derived lymphoma incidence J:209927
Ikzf1tm3Kge/Ikzf1tm3Kge
Tg(CD19-cre/ERT2)1Cgn/?
Not Specified 		abnormal B cell apoptosis J:209927
absent pre-B cells J:209927
decreased pre-B cell number J:209927
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory