55 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2mtm1Unc/B2mtm1Unc H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi Lattm1.1Mal/Lattm1.1Mal involves: 129P2/OlaHsd * 129S2/SvPas	absent CD4-positive, alpha-beta T cells	J:77098
	absent CD8-positive, alpha-beta T cells	J:77098
	normal immune system phenotype	J:77098
B2mtm1Unc/B2mtm1Unc Lattm1.1Mal/Lattm1.1Mal involves: 129P2/OlaHsd * 129S2/SvPas	abnormal immune system morphology	J:77098
Cbltm1.1Hua/Cbltm1.1Hua Lattm1Les/Lattm1Les involves: 129P2/OlaHsd	abnormal thymus development	J:91369
	increased CD4-positive, alpha-beta T cell number	J:91369
	liver inflammation	J:91369
	lung inflammation	J:91369
	thymus hypoplasia	J:91369
Cd3etm1Mal/Cd3etm1Mal Lattm1.1Mal/Lattm1.1Mal involves: 129S2/SvPas * C57BL/6	absent CD4-positive, alpha-beta T cells	J:77098
	absent CD8-positive, alpha-beta T cells	J:77098
	arrested T cell differentiation	J:77098
	normal immune system phenotype	J:77098
Foxp3tm1.1Mal/Foxp3tm1.1Mal Lattm1.1Mal/Lattm1.1Mal involves: 129S2/SvPas * C57BL/6	abnormal regulatory T cell physiology	J:131351
	decreased regulatory T cell number	J:131351
	thymus hypoplasia	J:131351
Il4tm1Lky/Il4+ Lattm1.1Mal/Lattm1.1Mal involves: 129S2/SvPas * C57BL/6	abnormal T-helper 2 physiology	J:151840
Lattm1.1Lov/Lattm1.1Lov involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal CD4-positive, alpha beta T cell morphology	J:77099, J:116157
	abnormal CD8-positive, alpha beta T cell morphology	J:77099
	abnormal cytokine secretion	J:77099
	abnormal double-negative T cell morphology	J:77099
	abnormal immunoglobulin level	J:77099
	abnormal lymph organ size	J:77099
	abnormal T cell differentiation	J:77099
	abnormal T cell physiology	J:77099
	decreased double-positive T cell number	J:77099
	decreased T cell proliferation	J:77099
	decreased thymocyte number	J:77099
	enlarged lymph nodes	J:77099, J:116157
	enlarged spleen	J:77099, J:116157
	increased activated T cell number	J:77099
	increased anti-double stranded DNA antibody level	J:116157
	increased anti-nuclear antigen antibody level	J:77099
	increased autoantibody level	J:77099
	increased IgE level	J:77099
	increased IgG1 level	J:77099
	increased IgM level	J:77099
	increased T cell proliferation	J:77099
	premature death	J:77099
	small thymus	J:77099
	spleen hyperplasia	J:116157
Lattm1.1Lov/Lattm1.1Lov Lat2tm1Wz/Lat2tm1Wz involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal CD4-positive, alpha beta T cell morphology	J:116157
	enlarged lymph nodes	J:116157
	enlarged spleen	J:116157
	increased anti-double stranded DNA antibody level	J:116157
	spleen hyperplasia	J:116157
Lattm1.1Mal/Lattm1.1Mal Rag1tm1Bal/Rag1tm1Bal involves: 129S2/SvPas * 129S4/SvJae	abnormal platelet dense granule physiology	J:125744
	decreased platelet aggregation	J:125744
Lattm1.1Mal/Lattm6.1(HBEGF/EGFP)Mal involves: 129S2/SvPas * C57BL/6	abnormal T-helper 2 physiology	J:151840
Lattm1Les/Lattm1Les Lat2tm1Wz/Lat2tm1Wz involves: C57BL/6	abnormal mast cell physiology	J:93951
Lattm1Les/Lattm1Les Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak involves: 129S1/Sv * 129X1/SvJ	arrested T cell differentiation	J:147721
	decreased double-positive T cell number	J:147721
Lattm1Les/Lattm1Les Tg(CD2-LAT2)1Wz/0 Not Specified	abnormal B cell physiology	J:116964
	abnormal interferon secretion	J:116964
	abnormal interleukin secretion	J:116964
	abnormal leukocyte physiology	J:116964
	abnormal single-positive T cell number	J:116964
	abnormal spleen periarteriolar lymphoid sheath morphology	J:116964
	abnormal T cell differentiation	J:116964
	decreased double-positive T cell number	J:116964
	enlarged spleen	J:116964
	increased IgG1 level	J:116964
	increased IgM level	J:116964
	increased interleukin-4 secretion	J:116964
	increased interleukin-10 secretion	J:116964
	small thymus	J:116964
	spleen hyperplasia	J:116964
Lattm2.1Mal/Lattm2.1Mal Lat2tm1Mal/Lat2tm1Mal involves: 129S2/SvPas	abnormal mast cell physiology	J:93950
Lattm2.1Mal/Lattm2.1Mal Rag1tm1Bal/Rag1tm1Bal involves: 129S2/SvPas * 129S4/SvJae	abnormal platelet dense granule physiology	J:125744
	abnormal thrombosis	J:125744
	decreased platelet aggregation	J:125744
Lattm4.1Mal/Lattm4.1Mal Tg(Lck*F505)3073Rmp/? involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal T-helper 2 physiology	J:151840
	increased CD4-positive, alpha-beta T cell number	J:151840
	increased IgE level	J:151840
	increased IgG1 level	J:151840
	increased interleukin-4 secretion	J:151840
	spleen hyperplasia	J:151840
Lattm4.1Mal/Lattm4.1Mal Trdctm1Mal/Trdctm1Mal involves: 129P2/OlaHsd * C57BL/6	abnormal double-negative T cell morphology	J:112658
Lattm4.1Mal/Lattm6.1(HBEGF/EGFP)Mal involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal T-helper 2 physiology	J:151840
Lattm6.1(HBEGF/EGFP)Mal/Lattm6.1(HBEGF/EGFP)Mal involves: 129S2/SvPas * C57BL/6	abnormal T cell activation	J:151840
	abnormal T-helper 2 physiology	J:151840
	decreased interferon-gamma secretion	J:151840
Lattm6.1(HBEGF/EGFP)Mal/? Rag2tm1Fwa/Rag2tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/? involves: 129S/SvEv * 129S2/SvPas * C57BL/6	abnormal T cell physiology	J:138401
Lattm8.1(CD2,-ECFP)Mal/Lattm8.1(CD2,-ECFP)Mal involves: 129S2/SvPas * C57BL/6	abnormal lymphocyte morphology	J:152149
	abnormal T cell receptor delta chain V(D)J recombination	J:152149
	abnormal T cell receptor gamma chain V-J recombination	J:152149
	arrested T cell differentiation	J:152149
	increased double-negative T cell number	J:152149
Lattm9Mal/Lattm9Mal Carmil2bas/Carmil2bas involves: C3HeB/FeJ * C57BL/6	normal immune system phenotype	J:205441