24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aicdatm1(cre)Mnz/Aicda+ Ightm3Mnz/Igh+ Myctm39Mnz/Myc+ involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:145691
	spontaneous chromosome breakage	J:145691
Aicdatm1(cre)Mnz/Aicda+ Ightm3Mnz/Igh+ Myctm37Mnz/Myc+ involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:145691
	spontaneous chromosome breakage	J:145691
Aicdatm1(cre)Mnz/Aicda+ Gt(ROSA)26Sortm2(sb11)Njen/Gt(ROSA)26Sor+ TgTn(sb-T2/Onc2)6070Njen/0 involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J	increased B cell derived lymphoma incidence	J:153656
	increased follicular lymphoma incidence	J:153656
	increased hemolymphoid system tumor incidence	J:153656
	increased leukemia incidence	J:153656
	increased medulloblastoma incidence	J:153656
	increased skin squamous cell carcinoma incidence	J:153656
	increased T cell derived lymphoma incidence	J:153656
	increased tumor incidence	J:153656
	premature death	J:153656
Aicdatm1Hon/Aicdatm1Hon Bcl6tm1.1Jwan/Bcl6tm1.1Jwan involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	abnormal somatic hypermutation frequency	J:190534
Aicdatm1Hon/Aicdatm1Hon Blmtm3Brd/Blmtm3Brd Ightm4.1Mnz/Igh+ Trp53bp1tm1Jc/Trp53bp1tm1Jc involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	normal immune system phenotype	J:194603
Aicdatm1Hon/Aicdatm1Hon Exo1tm1Wed/Exo1tm1Wed Ightm4.1Mnz/Igh+ involves: C57BL/6 * CBA/JNCrlj * SJL	abnormal immunoglobulin heavy chain V(D)J recombination	J:194603
Aicdatm1Hon/Aicdatm1Hon Exo1tm1Wed/Exo1tm1Wed Ightm4.1Mnz/Igh+ Trp53bp1tm1Jc/Trp53bp1tm1Jc involves: 129 * C57BL/6 * CBA/JNCrlj * SJL	abnormal immunoglobulin heavy chain V(D)J recombination	J:194603
Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Igh+ Myctm37Mnz/Myc+ involves: C57BL/6 * CBA	induced chromosome breakage	J:145691
Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz Trp53bp1tm1Jc/Trp53bp1tm1Jc involves: 129 * C57BL/6 * CBA	abnormal class switch recombination	J:159173
Aicdatm1Hon/Aicdatm1Hon Ightm4.1Mnz/Igh+ involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	abnormal immunoglobulin heavy chain V(D)J recombination	J:194603
Aicdatm1Hon/Aicdatm1Hon Ightm4.1Mnz/Igh+ Trp53bp1tm1Jc/Trp53bp1tm1Jc involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	abnormal immunoglobulin heavy chain V(D)J recombination	J:194603
Aicdatm1Hon/Aicdatm1Hon Ighmtm1.1(IGH-2)Cog/Ighm+ involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N	abnormal B cell physiology	J:157575
Aicdatm1Hon/Aicdatm1Hon Tg(Cr2-cre)3Cgn/? Xrcc4tm1Fwa/Xrcc4tm2Fwa involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA	spontaneous chromosome breakage	J:150339
Aicdatm1Hon/Aicdatm1Hon Tg(Igkv3-5*-MYC)#Plbe/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	normal immune system phenotype	J:131912
Bcl2l11tm1Ast/Bcl2l11tm1Ast Dicer1tm1Bdh/Dicer1tm1Bdh Aicdatm1(cre)Njen/Aicda+ involves: 129S1/Sv * C57BL/6	abnormal B cell differentiation	J:181782
	decreased germinal center B cell number	J:181782
	decreased plasma cell number	J:181782
Dicer1tm1Bdh/Dicer1tm1Bdh Aicdatm1(cre)Njen/Aicda+ involves: 129 * C57BL/6	abnormal germinal center B cell physiology	J:181782
	abnormal humoral immune response	J:181782
	absent memory B cells	J:181782
	absent plasma cells	J:181782
	decreased germinal center B cell number	J:181782
	decreased immunoglobulin level	J:181782
	normal immune system phenotype	J:181782
Ightm1Mnz/Ightm1Mnz Dis3tm1.1Uba/Dis3tm1.1Uba Aicdatm1(cre)Uba/Aicda+ involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	abnormal somatic hypermutation frequency	J:302856