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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MGI:1340044
29 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Lrp8tm1Her/Lrp8tm1Her
involves: 129S6/SvEvTac
abnormal brain development J:55691
abnormal cell death J:117956
abnormal cerebral cortex morphology J:105699
abnormal contextual conditioning behavior J:55691
abnormal dentate gyrus morphology J:55691, J:105699
abnormal hippocampus layer morphology J:105699
abnormal neuronal migration J:117956
abnormal Purkinje cell morphology J:55691
abnormal spatial learning J:100988
abnormal sperm flagellum morphology J:84102
abnormal sperm midpiece morphology J:84102
abnormal sperm mitochondrial sheath morphology J:84102
abnormal sperm physiology J:84102
abnormal spermatogenesis J:84102
asthenozoospermia J:84102
coiled sperm flagellum J:84102
hairpin sperm flagellum J:84102
kinked sperm flagellum J:84102
male infertility J:55691, J:84102
reduced cerebellar foliation J:55691
small cerebellum J:55691
Lrp8tm1Her/Lrp8tm1Her
involves: 129S6/SvEvTac * C57BL/6
abnormal cerebral cortex morphology J:129338
abnormal hippocampus pyramidal cell layer J:129338
Lrp8tm1Her/Lrp8tm1Her
involves: 129S6/SvEvTac * C57BL/6J
abnormal lateral ventricle morphology J:121846
abnormal postnatal subventricular zone morphology J:121846
abnormal rostral migratory stream morphology J:121846
Lrp8tm2.1Her/Lrp8tm2.1Her
involves: 129S6/SvEvTac
abnormal cell death J:117956
decreased motor neuron number J:117956
neuron degeneration J:117956
Lrp8tm2.1Her/Lrp8tm2.1Her
involves: 129S6/SvEvTac * C57BL/6J
no abnormal phenotype detected J:100988
Lrp8tm3Her/Lrp8tm3Her
involves: 129S6/SvEvTac * C57BL/6J
abnormal contextual conditioning behavior J:100988
abnormal spatial learning J:100988
reduced long-term potentiation J:100988
Lrp8tm5Her/Lrp8tm5Her
Not Specified
abnormal neuronal migration J:117956
neuron degeneration J:117956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory