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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
MGI:1339957
28 phenotypes from 8 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
P2rx7P451L/P2rx7P451L
C57BL/6
abnormal apoptosis J:89513
abnormal cell death J:89513
P2rx7tm1.1(P2RX7)Jde/P2rx7tm2.1(P2RX7*)Jde
involves: 129S2/SvPas * C57BL/6J
abnormal cell physiology J:251657
abnormal non-rapid eye movement sleep pattern J:251657
abnormal sleep behavior J:251657
abnormal slow-wave sleep pattern J:251657
normal behavior/neurological phenotype J:251657
fragmentation of sleep/wake states J:251657
increased frequency of paradoxical sleep J:251657
P2rx7tm1a(EUCOMM)Wtsi/P2rx7tm1a(EUCOMM)Wtsi
C57BL/6N-P2rx7tm1a(EUCOMM)Wtsi/Ieg
decreased circulating glycerol level J:165965
P2rx7tm1Blo/P2rx7tm1Blo
involves: 129
normal immune system phenotype J:97422
P2rx7tm1Blo/P2rx7tm1Blo
involves: 129 * C57BL/6
abnormal macrophage physiology J:118561
P2rx7tm1Blo/P2rx7tm1Blo
involves: 129 * C57BL/6 * DBA
normal cardiovascular system phenotype J:107324
P2rx7tm1Gab/P2rx7tm1Gab
B6.129P2-P2rx7tm1Gab/J
abnormal mast cell physiology J:190651
P2rx7tm1Gab/P2rx7tm1Gab
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)
abnormal cell death J:89513
abnormal interleukin-6 secretion J:66835
abnormal skeleton development J:84145
abnormal skeleton physiology J:84145
decreased body weight J:84145
decreased diameter of femur J:89513
decreased diameter of long bones J:84145
decreased diameter of tibia J:89513
decreased interleukin-1 beta secretion J:66835
increased osteoclast cell number J:84145
P2rx7tm1Gab/P2rx7tm1Gab
involves: 129P2/OlaHsd * C57BL/6
normal hearing/vestibular/ear phenotype J:178055
P2rx7tm1Ipch/P2rx7tm1Ipch
B6.Cg-P2rx7tm1Ipch
abnormal inflammatory response J:101945
abnormal pain threshold J:101945
P2rx7tm1Lex/P2rx7tm1Lex
involves: 129S5/SvEvBrd * C57BL/6
abnormal macrophage physiology J:145020
normal behavior/neurological phenotype J:145020
increased compensatory feeding amount J:145020
increased coping response J:145020

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory