Smc3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smc3
structural maintenance of chromosomes 3
MGI:1339795

29 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smc3^tm1.1Toshi/Smc3⁺ Tg(Icam5-cre)DYyos/0 involves: C57BL/6J * DBA/2J	abnormal pyramidal neuron dendrite morphology	J:242006
Smc3^tm1.1Toshi/Smc3⁺ Mapt^tm2(cre)Aha/Mapt⁺ involves: C57BL/6J	decreased CNS synapse formation	J:242006
	increased anxiety-related response	J:242006
Smc3^tm1.1Toshi/Smc3^tm1.1Toshi H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ B6.Cg-H2az2^{Tg(Wnt1-cre)11Rth} Smc3^tm1.1Toshi	cleft palate	J:242006
	small cranium	J:242006
Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Mapt^tm2(cre)Aha/? involves: C57BL/6J	decreased body size	J:242006
	postnatal growth retardation	J:242006
	premature death	J:242006
Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Tg(Nes-cre/ERT2)#Kag/0 involves: C57BL/6 * C57BL/6J	enlarged brain ventricles	J:242006
Smc3^tm1.2Toshi/Smc3⁺ B6.Cg-Smc3^tm1.2Toshi	abnormal dendritic mushroom spine morphology	J:242006
	abnormal dendritic thin spine morphology	J:242006
	abnormal postsynaptic density morphology	J:242006
	abnormal pyramidal neuron dendrite morphology	J:242006
	normal behavior/neurological phenotype	J:242006
	decreased CNS synapse formation	J:242006
	decreased dendritic spine density	J:242006
	normal growth/size/body region phenotype	J:242006
	hyperactivity	J:242006
	increased anxiety-related response	J:242006
	increased dendritic spine length	J:242006
	normal nervous system phenotype	J:242006
Smc3^tm1.2Toshi/Smc3^tm1.2Toshi B6.Cg-Smc3^tm1.2Toshi	embryonic lethality, complete penetrance	J:242006
Smc3^{tm1a(EUCOMM)Wtsi}/Smc3⁺ B6Dnk;B6Brd;B6N-Tyr^c-Brd Smc3^{tm1a(EUCOMM)Wtsi}/WtsiH	abnormal coat/hair pigmentation	J:175295
	decreased body weight	J:175295
	decreased bone mineral content	J:175295
	decreased lean body mass	J:175295
	decreased mean corpuscular hemoglobin	J:175295
	decreased total body fat amount	J:175295
Smc3^{tm1a(EUCOMM)Wtsi}/Smc3⁺ involves: C57BL/6N	abnormal craniofacial morphology	J:200082
	decreased body weight	J:200082
	increased T cell number	J:200082
	postnatal lethality, incomplete penetrance	J:200082
Smc3^{tm1a(EUCOMM)Wtsi}/Smc3^{tm1a(EUCOMM)Wtsi} B6Dnk;B6Brd;B6N-Tyr^c-Brd Smc3^{tm1a(EUCOMM)Wtsi}/WtsiH	preweaning lethality, complete penetrance	J:211773
Smc3^{tm1a(EUCOMM)Wtsi}/Smc3^{tm1a(EUCOMM)Wtsi} involves: C57BL/6N	embryonic lethality, complete penetrance	J:200082

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