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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Aire
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
MGI:1338803
14 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Airetm1.1Doi/Airetm1.1Doi
H2b/H2b
NOD.Cg-Airetm1.1Doi H2b/Doi
abnormal pancreas physiology J:107432
stomach inflammation J:107432
Airetm1.1Doi/Airetm1.1Doi
Idd3C57BL/6/Idd3C57BL/6
Idd5C57BL/10SnJ/Idd5C57BL/10SnJ
NOD.Cg-Idd3C57BL/6 Idd5C57BL/10SnJ Airetm1.1Doi/Doi
abnormal pancreas physiology J:107432
stomach inflammation J:107432
Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1+
involves: 129S2/SvPas * 129S7/SvEvBrd * NOD
abnormal conjunctiva goblet cell morphology J:163691
abnormal corneal epithelium morphology J:163691
abnormal lacrimal gland morphology J:163691
abnormal ocular surface morphology J:163691
corneal opacity J:163691
dry eyes J:163691
keratoconjunctivitis J:163691
lacrimal gland inflammation J:163691
Airetm1.1Doi/Airetm1.1Doi
Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S2/SvPas * 129S7/SvEvBrd * NOD
abnormal conjunctiva goblet cell morphology J:163691
abnormal corneal epithelium morphology J:163691
corneal opacity J:163691
dry eyes J:163691
keratoconjunctivitis J:163691
lacrimal gland inflammation J:163691
Airetm1.1Doi/Airetm1.1Doi
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T cell differentiation J:135154
decreased CD4-positive, alpha beta T cell number J:135154
Airetm1Mand/Aire+
Tg(Ins2-TFRC/OVA)296Wehi/0
Tg(TcraTcrb)425Cbn/0
involves: 129P2/OlaHsd * C57BL/6
abnormal T cell differentiation J:135154
Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6 * CBA
abnormal thymus morphology J:141379
normal immune system phenotype J:141379

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory