Prkab2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
MGI:1336185

21 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkab2^{Gt(AL0483)Wtsi}/Prkab2^{Gt(AL0483)Wtsi} B6.129P2-Prkab2^{Gt(AL0483)Wtsi}	decreased circulating glucose level	J:186658
	decreased glycogen catabolism rate	J:186658
	decreased muscle cell glucose uptake	J:186658
	decreased skeletal muscle glycogen level	J:186658
	impaired exercise endurance	J:186658
	impaired glucose tolerance	J:186658
	increased circulating insulin level	J:186658
	increased circulating triglyceride level	J:186658
	increased total body fat amount	J:186658
	insulin resistance	J:186658
Prkab2^tm1.1Grst/Prkab2^tm1.1Grst involves: C57BL/6	abnormal glucose homeostasis	J:167339
	abnormal lipid homeostasis	J:167339
	decreased liver glycogen level	J:167339
	decreased muscle cell glucose uptake	J:167339
	decreased physiological sensitivity to xenobiotic	J:167339
	decreased skeletal muscle fiber size	J:167339
	decreased skeletal muscle glycogen level	J:167339
	impaired exercise endurance	J:167339
	increased circulating insulin level	J:167339
	increased muscle cell glucose uptake	J:167339
	increased susceptibility to diet-induced obesity	J:167339
	insulin resistance	J:167339
	muscle weakness	J:167339
Prkab2^{tm1b(EUCOMM)Hmgu}/Prkab2⁺ C57BL/6N-Prkab2^{tm1b(EUCOMM)Hmgu}/H	decreased mean platelet volume	J:211773
	increased eosinophil cell number	J:211773
Prkab2^{tm1b(EUCOMM)Hmgu}/Prkab2^{tm1b(EUCOMM)Hmgu} C57BL/6N-Prkab2^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, incomplete penetrance	J:211773
Prkab2^tm1Grst/Prkab2^tm1Grst Tg(Ckmm-cre)5Khn/0 involves: C57BL/6 * FVB	impaired exercise endurance	J:176578

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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