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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lats1
large tumor suppressor
MGI:1333883
38 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Lats1em1(IMPC)H/Lats1+
C57BL/6NTac-Lats1em1(IMPC)H/H
decreased grip strength J:211773
Lats1em1(IMPC)H/Lats1em1(IMPC)H
C57BL/6NTac-Lats1em1(IMPC)H/H
decreased hemoglobin content J:211773
decreased locomotor activity J:211773
decreased prepulse inhibition J:211773
increased circulating alanine transaminase level J:211773
increased grip strength J:211773
increased neutrophil cell number J:211773
Lats1tm1.1Jfm/Lats1tm1.1Jfm
involves: 129S6/SvEvTac * C57BL/6Brd * CD-1
no abnormal phenotype detected J:101977
Lats1tm1Noj/Lats1tm1Noj
involves: 129S2/SvPas * C57BL/6
abnormal cell physiology J:200232
abnormal centrosome morphology J:200232
abnormal mitosis J:200232
abnormal mitotic spindle morphology J:200232
abnormal tumor morphology J:200232
decreased body weight J:200232
increased fibroblast proliferation J:200232
normal neoplasm J:200232
postnatal growth retardation J:200232
prenatal lethality, incomplete penetrance J:200232
Lats1tm1Tx/Lats1tm1Tx
involves: 129S2/SvPas * C57BL/6J
abnormal female reproductive system morphology J:52536
abnormal fertility/fecundity J:52536
abnormal mammary gland development J:52536
abnormal ovarian follicle morphology J:52536
absent corpus luteum J:52536
absent estrous cycle J:52536
absent nipple J:52536
adenohypophysis hyperplasia J:52536
decreased body weight J:52536
decreased circulating growth hormone level J:52536
decreased circulating luteinizing hormone level J:52536
decreased circulating prolactin level J:52536
decreased mature ovarian follicle number J:52536
female infertility J:52536
impaired ovarian folliculogenesis J:52536
increased ovary tumor incidence J:52536
increased sarcoma incidence J:52536
internal hemorrhage J:52536
neonatal lethality, incomplete penetrance J:52536
postnatal lethality, incomplete penetrance J:52536
reduced fertility J:52536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory