170 phenotypes from 20 alleles in 17 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(KRT5-cre/PGR)1Der/0 Trp63tm2Brd/Trp63tm3.1Brd involves: 129S7/SvEvBrd * FVB * ICR	abnormal craniofacial morphology	J:100483
	abnormal epidermal layer morphology	J:100483
	abnormal limb morphology	J:100483
	abnormal skin morphology	J:100483
	alopecia	J:100483
	early cellular replicative senescence	J:100483
	lordokyphosis	J:100483
	weight loss	J:100483
Trp63m1Mhda/Trp63+ C3HeB/FeJ-Trp63m1Mhda	no abnormal phenotype detected	J:82809
Trp63m1Mhda/Trp63m1Mhda C3HeB/FeJ-Trp63m1Mhda	abnormal craniofacial morphology	J:82809
	absent limbs	J:82809
	prenatal lethality, complete penetrance	J:82809
Trp63tm1.1(cre)Ssig/Trp63+ involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:197339
Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig involves: 129S/SvEv * C57BL/6	abnormal craniofacial morphology	J:197339
	abnormal esophageal epithelium morphology	J:197339
	absent epidermis	J:197339
	absent limbs	J:197339
Trp63tm1.1Elrf/Trp63tm1.1Elrf involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal esophageal epithelium morphology	J:151638
	abnormal skin physiology	J:151638
	abnormal urinary bladder urothelium morphology	J:151638
	aneuploidy	J:151638
	blistering	J:151638
	chromosomal instability	J:151638
	decreased hair follicle number	J:151638
	early cellular replicative senescence	J:151638
	gastric cyst	J:151638
	impaired wound healing	J:151638
	kidney cyst	J:151638
	kyphosis	J:151638
	normal mortality/aging	J:151638
	premature aging	J:151638
	premature death	J:151638
	spontaneous skin ulceration	J:151638
Trp63tm1.1Elrf/Trp63tm1.1Elrf involves: C57BL/6 * FVB/N	abnormal esophageal epithelium morphology	J:151638
	abnormal skin physiology	J:151638
	abnormal urinary bladder urothelium morphology	J:151638
	aneuploidy	J:151638
	blistering	J:151638
	chromosomal instability	J:151638
	decreased hair follicle number	J:151638
	early cellular replicative senescence	J:151638
	embryonic lethality, incomplete penetrance	J:151638
	gastric cyst	J:151638
	impaired wound healing	J:151638
	kidney cyst	J:151638
	kyphosis	J:151638
	premature aging	J:151638
	premature death	J:151638
	spontaneous skin ulceration	J:151638
Trp63tm1Aam/Trp63+ Not Specified	abnormal phalanx morphology	J:135784
	ectrodactyly	J:135784
Trp63tm1Aam/Trp63tm1Aam Not Specified	abnormal apical ectodermal ridge morphology	J:135784
	abnormal craniofacial morphology	J:135784
	abnormal ectoderm development	J:135784
	absent hindlimb	J:135784
	short forelimb	J:135784
	small limb buds	J:135784
Trp63tm1Brd/Trp63tm1Brd involves: 129S7/SvEvBrd	abnormal skin physiology	J:151638
Trp63tm1Brd/Trp63tm1Brd involves: 129S7/SvEvBrd * C57BL/6J	abnormal epidermal layer morphology	J:54636
	abnormal facial morphology	J:54636
	abnormal humerus morphology	J:54636
	abnormal limb bone morphology	J:54636
	abnormal pelvic girdle bone morphology	J:54636
	abnormal phalanx morphology	J:54636
	abnormal skin condition	J:54636
	abnormal skin physiology	J:54636
	absent apical ectodermal ridge	J:54636
	absent carpal bone	J:54636
	absent epidermis stratum corneum	J:54636
	absent epidermis stratum granulosum	J:54636
	absent epidermis stratum spinosum	J:54636
	absent hair follicles	J:54636
	absent hindlimb	J:54636
	absent radius	J:54636
	absent teeth	J:54636
	absent ulna	J:54636
	impaired skin barrier function	J:54636
	neonatal lethality, complete penetrance	J:54636
	shiny skin	J:54636
	short forelimb	J:54636
	small limb buds	J:54636
	translucent skin	J:54636
Trp63tm1Cmis/Trp63+ involves: 129P2/OlaHsd * C57BL/6	abnormal epidermal layer morphology	J:191121
	abnormal keratinocyte physiology	J:191121
	blistering	J:191121
	cleft palate	J:191121
	neonatal lethality, complete penetrance	J:191121
Trp63tm1Elrf/Trp63tm1Elrf Tg(KRT14-cre)8Brn/0 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * FVB/N	normal homeostasis/metabolism phenotype	J:151638
	normal integument phenotype	J:151638
Trp63tm1Fmc/Trp63+ involves: 129S4/SvJae	abnormal female reproductive system morphology	J:79340
	small uterus	J:79340
Trp63tm1Fmc/Trp63+ involves: 129S4/SvJae * C57BL/6	increased histiocytic sarcoma incidence	J:98958
	increased lung adenoma incidence	J:98958
	increased malignant tumor incidence	J:98958
	increased squamous cell carcinoma incidence	J:98958
	increased tumor incidence	J:98958
	intervertebral disk degeneration	J:98958
	premature aging	J:98958
	premature death	J:98958
Trp63tm1Fmc/Trp63tm1Fmc involves: 129S2/SvPas * BALB/c	normal reproductive system phenotype	J:116176
Trp63tm1Fmc/Trp63tm1Fmc involves: 129S4/SvJae	abnormal craniofacial morphology	J:79340
	abnormal esophageal epithelium morphology	J:54637
	abnormal esophageal squamous epithelium morphology	J:54637
	abnormal female reproductive system morphology	J:79340
	abnormal forelimb morphology	J:54637
	abnormal hair shaft morphology	J:54637
	abnormal limb bud morphology	J:54637
	abnormal limb development	J:54637
	abnormal prostate gland branching morphogenesis	J:66126
	abnormal secondary palate development	J:54637
	abnormal septation of the cloaca	J:79340
	abnormal stomach epithelium morphology	J:173368
	abnormal stomach non-glandular epithelium morphology	J:54637
	abnormal urinary bladder urothelium morphology	J:79341
	abnormal uterine cervix epithelium morphology	J:54637
	abnormal vagina epithelium morphology	J:54637
	abnormal ventral body wall morphology	J:79340
	absent apical ectodermal ridge	J:54637
	absent carpal bone	J:54637
	absent epidermis	J:54637, J:79340
	absent eyelids	J:54637
	absent hair follicles	J:54637
	absent hindlimb	J:54637
	absent lacrimal glands	J:54637
	absent limbs	J:79340
	absent mammary gland	J:54637
	absent ovary	J:79340
	absent oviduct	J:79340
	absent prostate gland	J:66126
	absent radius	J:54637
	absent salivary gland	J:54637
	absent sebaceous gland	J:54637
	absent tongue squamous epithelium	J:54637
	absent tooth placode	J:54637
	absent urinary bladder urothelium	J:54637
	absent vibrissae	J:54637
	adactyly	J:54637
	clitoris hypoplasia	J:79340
	decreased apoptosis	J:178316
	esophagogastric junction metaplasia	J:173368
	gastric metaplasia	J:173368
	increased apoptosis	J:54637
	neonatal lethality, complete penetrance	J:54637
	rectovaginal fistula	J:79340
	small limb buds	J:54637
	small mandible	J:54637
	small maxilla	J:54637
	small tail bud	J:79340
	thin urinary bladder urothelium	J:54637
Trp63tm1Fmc/Trp63tm1Fmc involves: 129S4/SvJae * C57BL/6	abnormal esophageal squamous epithelium morphology	J:95347
	abnormal esophagus development	J:95347
	abnormal respiratory epithelium morphology	J:95347
	abnormal tracheal ciliated epithelium morphology	J:95347
Trp63tm1Sin/Trp63tm1Sin involves: C57BL/6	abnormal limb morphology	J:173538
	abnormal olfactory epithelium morphology	J:173538
	abnormal skin morphology	J:173538
Trp63tm1Sin/Trp63tm1Sin Not Specified	abnormal craniofacial development	J:181275
	abnormal embryo development	J:181275
	abnormal keratinocyte differentiation	J:181275
	abnormal keratinocyte morphology	J:181275
	abnormal keratinocyte physiology	J:181275
	abnormal limb development	J:181275
	abnormal periderm morphology	J:315539
	abnormal secondary palate development	J:315539
	abnormal skin development	J:181275
	absent epidermis	J:181275
	absent hair follicles	J:181275
	absent sebaceous gland	J:181275
	cleft palate	J:315539
	decreased fetal size	J:181275
	decreased keratinocyte proliferation	J:181275
	dehydration	J:181275
	neonatal lethality, complete penetrance	J:181275
Trp63tm2.1Aam/Trp63tm2.1Aam Not Specified	abnormal cellular replicative senescence	J:158291
	normal embryo phenotype	J:158291
	normal neoplasm	J:158291
Trp63tm2.1Aam/Trp63tm3.1Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6	abnormal epidermal layer morphology	J:294158
	cleft palate	J:294158
	normal limbs/digits/tail phenotype	J:294158
	thick dermal layer	J:294158
	thick epidermis	J:294158
	thick epidermis stratum basale	J:294158
	thick epidermis stratum spinosum	J:294158
Trp63tm2.1Aam/Trp63tm3.2Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6	cleft palate	J:294158
	normal limbs/digits/tail phenotype	J:294158
	thick epidermis	J:294158
Trp63tm2.1Aam/Trp63tm3Aam involves: 129S7/SvEvBrd	abnormal epidermal layer morphology	J:294158
	abnormal limb morphology	J:294158
	cleft palate	J:294158
	ectrodactyly	J:294158
	thick dermal layer	J:294158
	thick epidermis stratum basale	J:294158
	thick epidermis stratum spinosum	J:294158
Trp63tm2.2Elrf/Trp63+ Not Specified	abnormal epidermis stratum basale morphology	J:206433
	wrinkled skin	J:206433
Trp63tm2.2Elrf/Trp63tm2.2Elrf Not Specified	abnormal epidermal layer morphology	J:206433
	abnormal epidermis stratum basale morphology	J:206433
	abnormal epidermis stratum spinosum morphology	J:206433
	dermal-epidermal separation	J:206433
	neonatal lethality, complete penetrance	J:206433
Trp63tm2Aam/Trp63tm2Aam Not Specified	abnormal cellular replicative senescence	J:158291
Trp63tm2Brd/Trp63+ B6.129S7-Trp63tm2Brd/J	abnormal horizontal basal cell of olfactory epithelium morphology	J:173538
Trp63tm2Brd/Trp63+ involves: 129S7/SvEvBrd	abnormal corneal epithelium morphology	J:100483
	abnormal rectum morphology	J:100483
	abnormal tongue epithelium morphology	J:100483
	abnormal uterine cervix epithelium morphology	J:100483
	acanthosis	J:100483
	alopecia	J:100483
	circling	J:100483
	distended abdomen	J:100483
	enlarged lymph nodes	J:100483
	hemorrhage	J:100483
	increased susceptibility to infection	J:100483
	kidney inflammation	J:100483
	premature aging	J:100483
	premature death	J:100483
	rectal prolapse	J:100483
	skin lesions	J:100483
	spontaneous skin ulceration	J:100483
	uterine cervix inflammation	J:100483
	weakness	J:100483
Trp63tm2Brd/Trp63tm2Brd B6.129S7-Trp63tm2Brd/J	abnormal horizontal basal cell of olfactory epithelium morphology	J:173538
	abnormal olfactory epithelium morphology	J:173538
	abnormal olfactory gland morphology	J:173538
Trp63tm2Brd/Trp63tm2Brd involves: 129S7/SvEvBrd	abnormal apical ectodermal ridge morphology	J:135784
	abnormal craniofacial morphology	J:100483
	abnormal epidermal layer morphology	J:100483
	abnormal limb morphology	J:100483
	abnormal skin morphology	J:100483
	decreased cell proliferation	J:100483
	early cellular replicative senescence	J:100483
	normal muscle phenotype	J:98439
Trp63tm2Brd/Trp63tm2Brd involves: 129S7/SvEvBrd * C57BL/6J	abnormal abdominal wall morphology	J:119657
	abnormal anus morphology	J:119657
	abnormal epidermal layer morphology	J:54636
	abnormal facial morphology	J:54636
	abnormal hair follicle development	J:54636
	abnormal humerus morphology	J:54636
	abnormal limb bone morphology	J:54636
	abnormal mitochondrial physiology	J:119657
	abnormal pelvic girdle bone morphology	J:54636
	abnormal phalanx morphology	J:54636
	abnormal primitive urogenital sinus morphology	J:119657
	abnormal reproductive system morphology	J:119657
	abnormal skin condition	J:54636
	abnormal skin physiology	J:54636
	abnormal urinary bladder detrusor smooth muscle morphology	J:119657
	abnormal urinary bladder urothelium morphology	J:119657
	absent apical ectodermal ridge	J:54636
	absent carpal bone	J:54636
	absent epidermis stratum corneum	J:54636
	absent epidermis stratum granulosum	J:54636
	absent epidermis stratum spinosum	J:54636
	absent hindlimb	J:54636
	absent pubic symphysis	J:119657
	absent radius	J:54636
	absent teeth	J:54636
	absent ulna	J:54636
	absent urinary bladder urothelium	J:119657
	distended urinary bladder	J:119657
	impaired skin barrier function	J:54636
	increased apoptosis	J:119657
	neonatal lethality, complete penetrance	J:54636
	shiny skin	J:54636
	short forelimb	J:54636
	small limb buds	J:54636
	translucent skin	J:54636
	umbilical hernia	J:119657
	urinary bladder exstrophy	J:119657
Trp63tm2Fmc/Trp63tm2Fmc involves: BALB/c	decreased cellular sensitivity to ionizing radiation	J:116176
Trp63tm3.1Aam/Trp63+ involves: 129S7/SvEvBrd * BALB/c * C57BL/6	abnormal keratinocyte physiology	J:294158
	cleft palate	J:294158
	decreased keratinocyte proliferation	J:294158
Trp63tm3.1Aam/Trp63tm3.1Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6	abnormal embryo development	J:294158
	abnormal limb morphology	J:294158
	abnormal skin development	J:294158
	perinatal lethality, complete penetrance	J:294158
	short limbs	J:294158
Trp63tm3.1Brd/Trp63tm3.1Brd involves: 129S7/SvEvBrd	decreased cell proliferation	J:100483
	early cellular replicative senescence	J:100483
Trp63tm3.2Aam/Trp63+ involves: 129S7/SvEvBrd * BALB/c * C57BL/6	normal craniofacial phenotype	J:294158
	preweaning lethality, incomplete penetrance	J:294158
Trp63tm3.2Aam/Trp63tm3.2Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6	abnormal embryo development	J:294158
	abnormal limb morphology	J:294158
	abnormal skin development	J:294158
	perinatal lethality, complete penetrance	J:294158
	short limbs	J:294158
Trp63tm3.2Brd/Trp63tm3.2Brd involves: 129S7/SvEvBrd	absent hair follicles	J:75125
	absent hindlimb	J:75125
	short forelimb	J:75125
Trp63tm3Aam/Trp63+ involves: 129S7/SvEvBrd	abnormal eye morphology	J:294158
	abnormal keratinocyte physiology	J:294158
	abnormal limb morphology	J:294158
	abnormal palatal shelf fusion at midline	J:294158
	abnormal tooth development	J:294158
	abnormal tooth root morphology	J:294158
	absent gastric milk in neonates	J:294158
	alopecia	J:294158
	cleft palate	J:294158
	decreased keratinocyte proliferation	J:294158
	nail dystrophy	J:294158
	perinatal lethality, incomplete penetrance	J:294158
	ruffled hair	J:294158
	supernumerary teeth	J:294158
Trp63tm3Aam/Trp63tm3Aam involves: 129S7/SvEvBrd	abnormal embryo development	J:294158
	abnormal limb morphology	J:294158
	abnormal skin development	J:294158
	perinatal lethality, complete penetrance	J:294158
	short limbs	J:294158
Trp63tm3Brd/Trp63tm3Brd involves: 129S7/SvEvBrd	no abnormal phenotype detected	J:75125