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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dyrk1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
MGI:1330299
44 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Dyrk1aGt(XQ0369)Wtsi/Dyrk1a+
involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
transmission ratio distortion J:224899
Dyrk1aGt(XQ0369)Wtsi/Dyrk1aGt(XQ0369)Wtsi
involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
embryonic lethality, complete penetrance J:224899
Dyrk1atm1Jdc/Dyrk1atm1Jdc
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6J * C57BL/6NTac * CBA/J
abnormal cell cycle J:223138
decreased B cell number J:223138
decreased double-positive T cell number J:223138
decreased immature B cell number J:223138
decreased mature B cell number J:223138
decreased pre-B cell number J:223138
decreased thymocyte number J:223138
increased T cell apoptosis J:223138
Dyrk1atm1Mla/Dyrk1a+
involves: 129P2/OlaHsd
abnormal brain size J:182294
abnormal dentate gyrus morphology J:182294
abnormal somatosensory cortex morphology J:182294
abnormal thalamus morphology J:182294
decreased hippocampus volume J:182294
Dyrk1atm1Mla/Dyrk1a+
involves: 129P2/OlaHsd * C57BL/6
abnormal cerebral cortex pyramidal cell morphology J:102616
abnormal premotor cortex morphology J:102616
decreased body length J:78597
decreased body size J:78597
decreased body weight J:78597
decreased brain size J:78597
decreased brain weight J:78597
decreased heart weight J:78597
decreased hindbrain size J:78597
decreased liver weight J:78597
decreased midbrain size J:78597
decreased superior colliculus size J:78597
microcephaly J:102616
postnatal lethality, incomplete penetrance J:78597
small tectum J:78597
Dyrk1atm1Mla/Dyrk1atm1Mla
involves: 129P2/OlaHsd * C57BL/6
abnormal nervous system development J:78597
decreased embryo size J:78597
embryonic growth retardation J:78597
embryonic lethality during organogenesis, incomplete penetrance J:78597
Tg(Dyrk1a)189N3Yah/0
B6.129S2/SvPas-Tg(Dyrk1a)189N3Yah
abnormal dentate gyrus morphology J:182294
abnormal hippocampus molecular cell layer J:182294
abnormal hippocampus morphology J:182294
abnormal hippocampus stratum oriens morphology J:182294
abnormal lateral ventricle morphology J:182294
abnormal somatosensory cortex morphology J:182294
abnormal thalamus morphology J:182294
abnormal third ventricle morphology J:182294
decreased body length J:182294
decreased body weight J:182294
increased brain size J:182294
increased brain weight J:182294
lethality, incomplete penetrance J:182294
postnatal growth retardation J:182294
shortened head J:182294

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory