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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Edil3
EGF-like repeats and discoidin I-like domains 3
MGI:1329025
374 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Abcb7tm1Mdf/Abcb7+
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: B6.Cg-Edil3Tg(Sox2-cre)1Amc Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA)
normal mortality/aging J:106838
Abcb7tm1Mdf/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: B6.Cg-Edil3Tg(Sox2-cre)1Amc Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA)
embryonic lethality between somite formation and embryo turning, complete penetrance J:106838
Arap3tm1.1Sve/Arap3tm1.2Sve
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL
abnormal placenta labyrinth morphology J:185401
abnormal placenta vasculature J:185401
decreased embryo size J:185401
decreased placental labyrinth size J:185401
embryonic growth arrest J:185401
embryonic lethality during organogenesis, complete penetrance J:185401
excessive folding of visceral yolk sac J:185401
pale yolk sac J:185401
pallor J:185401
Casz1tm1.1Flc/Casz1tm1.1Flc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL
abnormal heart development J:221324
embryonic lethality during organogenesis, complete penetrance J:221324
heart hypoplasia J:221324
thin ventricular wall J:221324
ventricular septal defect J:221324
Cdx2tm1Fbe/Cdx2tm2Fbe
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA
caudal body truncation J:179732
Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan
Edil3Tg(Sox2-cre)1Amc/?
involves: 129P2/OlaHsd * C57BL/6J * CBA
embryonic lethality, complete penetrance J:217689
Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA * SJL
abnormal heart left ventricle morphology J:137951
abnormal inferior vena cava morphology J:137951
absent adrenal gland J:137951
absent coronary sinus J:137951
common atrioventricular valve J:137951
dextrocardia J:137951
double outlet right ventricle J:137951
exencephaly J:137951
lethality throughout fetal growth and development, incomplete penetrance J:137951
ostium primum atrial septal defect J:137951
postnatal lethality, complete penetrance J:137951
right aortic arch J:137951
right atrial isomerism J:137951
right pulmonary isomerism J:137951
transposition of great arteries J:137951
ventricular septal defect J:137951
Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6N
prenatal lethality, complete penetrance J:230747
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
abnormal embryonic tissue morphology J:187739
prenatal lethality, complete penetrance J:187739
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
abnormal embryonic tissue morphology J:187739
abnormal germ layer development J:187739
failure to gastrulate J:187739
prenatal lethality, complete penetrance J:187739
Ctsdtm1.1Thre/Ctsdtm1.1Thre
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * C57BL/6N * CBA * SJL
astrocytosis J:227618
decreased body weight J:227618
decreased double-positive T cell number J:227618
decreased small intestinal villus height J:227618
gliosis J:227618
microgliosis J:227618
neuron degeneration J:227618
premature death J:227618
small intestinal villus atrophy J:227618
thymus atrophy J:227618
weight loss J:227618
Cul4btm1.1Pz/Cul4b+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA
normal mortality/aging J:199210
Cul4btm1.1Pz/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA
no abnormal phenotype detected J:199210
Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl
abnormal dendrite morphology J:187403
abnormal dendritic spine morphology J:187403
abnormal spatial learning J:187403
abnormal spatial working memory J:187403
decreased neuron number J:187403
increased susceptibility to pharmacologically induced seizures J:187403
Dab2tm2.1Xxx/Dab2tm2.2Xxx
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
normal embryo phenotype J:205046
increased circulating cholesterol level J:205046
increased circulating LDL cholesterol level J:205046
normal mortality/aging J:205046
Dag1tm1Kcam/Dag1tm2.1Kcam
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal axon fasciculation J:194150
abnormal axon guidance J:194150
abnormal basement membrane morphology J:194150
abnormal spinal cord dorsal column morphology J:194150
abnormal spinal cord ventral commissure morphology J:194150
radial glial endfoot detachment J:194150
Ddx3xtm1.1Lyou/Ddx3x+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA
no abnormal phenotype detected J:231798
Ddx3xtm1.1Lyou/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA
abnormal allantois morphology J:231798
abnormal brain development J:231798
abnormal cell cycle J:231798
abnormal cell physiology J:231798
abnormal developmental patterning J:231798
abnormal embryo turning J:231798
abnormal head fold morphology J:231798
abnormal myocardial trabeculae morphology J:231798
abnormal neural tube closure J:231798
embryonic growth retardation J:231798
embryonic lethality prior to tooth bud stage J:231798
failure of chorioallantoic fusion J:231798
increased embryonic tissue cell apoptosis J:231798
increased mitotic index J:231798
microcephaly J:231798
pericardial effusion J:231798
preweaning lethality, complete penetrance J:231798
small allantois J:231798
Dicer1tm1Bdh/Dicer1tm1Bdh
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA
spina bifida J:244791
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129/Sv * C57BL/6J * SWR
abnormal frontonasal prominence morphology J:94270
perinatal lethality, complete penetrance J:94270
Disp1tm1Pab/Disp1tm1Pab
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal digit morphology J:109101
perinatal lethality, complete penetrance J:109101
preaxial polydactyly J:109101
Dph1tm1.1Cmch/Dph1tm1.1Cmch
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
abnormal tongue morphology J:214744
absent palatine bone J:214744
cleft palate J:214744
edema J:214744
fetal growth retardation J:214744
mandible hypoplasia J:214744
neonatal lethality, complete penetrance J:214744
palatal shelves fail to meet at midline J:214744
pallor J:214744
short mandible J:214744
small cranium J:214744
E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * SJL
abnormal embryonic tissue morphology J:183999
abnormal respiratory system morphology J:183999
normal embryo phenotype J:183999
neonatal lethality J:183999
Edil3Tg(Sox2-cre)1Amc/Edil3+
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal blood-brain barrier function J:142352
abnormal vasculogenesis J:142352
embryonic lethality during organogenesis, complete penetrance J:142352
intracranial hemorrhage J:142352
spinal hemorrhage J:142352
Edil3Tg(Sox2-cre)1Amc/Edil3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
abnormal cephalic neural fold morphology J:183402
abnormal direction of heart looping J:157256
abnormal forebrain development J:183402
abnormal forebrain morphology J:183402
abnormal heart looping J:157256
abnormal left-right axis patterning J:157256
abnormal olfactory epithelium morphology J:183402
abnormal optic vesicle formation J:183402
abnormal primitive streak elongation J:157256
cyclopia J:183402
decreased embryonic neuroepithelial cell proliferation J:183402
decreased embryonic neuroepithelium thickness J:183402
decreased forebrain size J:183402
embryonic lethality during organogenesis, complete penetrance J:157256
embryonic lethality during organogenesis, incomplete penetrance J:183402
failure of heart looping J:157256
heterotaxia J:183402
incomplete rostral neuropore closure J:183402
increased apoptosis J:183402
proboscis J:183402
Edil3Tg(Sox2-cre)1Amc/Edil3+
Strip1tm1b(KOMP)Wtsi/Strip1tm1c(KOMP)Wtsi
involves: C57BL/6N * CBA * FVB/NJ * SJL
abnormal head fold morphology J:251816
abnormal mesoderm development J:251816
cardia bifida J:251816
normal embryo phenotype J:251816
short rostral-caudal axis J:251816
Edil3Tg(Sox2-cre)1Amc/0
Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
involves: C57BL/6 * CBA
embryonic lethality, complete penetrance J:256652
Edil3tm1Tq/Edil3tm1Tq
Itgaltm1Bll/Itgaltm1Bll
involves: 129 * C57BL/6
abnormal cellular extravasation J:141063
abnormal neutrophil physiology J:141063
Eef1a1tm1Tcrl/Eef1a1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA
holoprosencephaly J:225273
lethality throughout fetal growth and development, incomplete penetrance J:225273
open neural tube J:225273
postnatal lethality, complete penetrance J:225273
spina bifida J:225273
Elavl1tm1Dkon/Elavl1tm1Dkon
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal craniofacial bone morphology J:149149
abnormal lung development J:149149
abnormal spleen development J:149149
abnormal vertebrae development J:149149
absent spleen J:149149
delayed endochondral bone ossification J:149149
lethality throughout fetal growth and development, complete penetrance J:149149
midline facial cleft J:149149
short limbs J:149149
small limb buds J:149149
split xiphoid process J:149149
syndactyly J:149149
synostosis J:149149
Enpp2tm1Vart/Enpp2tm1Vart
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
embryonic lethality J:159118
Eomestm1Rob/Eomes+
Nodaltm1Rob/Nodal+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA
prenatal lethality J:131055
rostral body truncation J:131055
Eomestm1Rob/Eomestm1.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA
abnormal embryonic epiblast morphology J:131055
abnormal primitive streak morphology J:131055
absent mesoderm J:131055
Eomestm1Rob/Eomestm1.1Rob
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
abnormal endoderm development J:131055
abnormal visceral endoderm morphology J:131055
Eomestm1Rob/Eomestm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA
abnormal embryonic epiblast morphology J:154785
abnormal primitive streak morphology J:154785
failure to gastrulate J:154785
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA
preweaning lethality, complete penetrance J:152703
Esrrbtm1.1Nat/Esrrbtm1.2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
abnormal scala media morphology J:124941
abnormal semicircular canal ampulla morphology J:124941
abnormal semicircular canal morphology J:124941
absent startle reflex J:124941
circling J:124941
decreased endolymph production J:124941
head bobbing J:124941
increased or absent threshold for auditory brainstem response J:124941
small scala media J:124941
Evc2tm2.1Mis/Evc2tm2.1Mis
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129X1/SvJ * C57BL/6 * CBA
disproportionate dwarf J:226455
Fam20ctm1.1Cqi/Fam20ctm1.1Cqi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA
abnormal chondrocyte differentiation J:185208
abnormal circulating protein level J:185208
abnormal limb long bone morphology J:185208
abnormal long bone diaphysis morphology J:185208
abnormal long bone epiphyseal plate morphology J:185208
abnormal long bone epiphyseal plate proliferative zone J:185208
abnormal osteocyte morphology J:185208
abnormal skeleton morphology J:185208
abnormal vertebral column morphology J:185208
abnormal vitamin D level J:185208
decreased body size J:185208
decreased body weight J:185208
decreased bone mineral density J:185208
decreased bone mineralization J:185208
decreased chondrocyte apoptosis J:185208
decreased chondrocyte proliferation J:185208
decreased circulating phosphate level J:185208
decreased compact bone thickness J:185208
delayed bone ossification J:185208
delayed cranial suture closure J:185208
delayed endochondral bone ossification J:185208
female infertility J:185208
flat face J:185208
fragile skeleton J:185208
impaired osteoblast differentiation J:185208
increased circulating parathyroid hormone level J:185208
increased width of hypertrophic chondrocyte zone J:185208
male infertility J:185208
osteomalacia J:185208
postnatal growth retardation J:185208
rickets J:185208
short snout J:185208
small cranium J:185208
Fnip1m1Btlr/Fnip1m1Btlr
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA
normal cardiovascular system phenotype J:256296
Foxp2tm1Sfis/Foxp2tm1.2Sfis
Edil3Tg(Sox2-cre)1Amc/?
involves: C57BL/6 * CBA * SJL
decreased body weight J:125023
delayed eyelid opening J:125023
impaired righting response J:125023
lethality at weaning, complete penetrance J:125023
reduced cerebellar foliation J:125023
small cerebellum J:125023
Fzd4tm1Nat/Fzd4+
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA
abnormal angiogenesis J:154020
abnormal descending aorta morphology J:154020
embryonic growth retardation J:154020
embryonic lethality, incomplete penetrance J:154020
Fzd4tm1Nat/Fzd4tm1Nat
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA
normal cardiovascular system phenotype J:154020
normal growth/size/body region phenotype J:154020
normal mortality/aging J:154020
Fzd5tm1Nat/Fzd5tm2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
abnormal thalamus morphology J:136390
decreased body size J:136390
decreased body weight J:136390
impaired coordination J:136390
retinal degeneration J:136390
Fzr1tm1Mama/Fzr1tm1.1Mama
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: BALB/cJ * C57BL/6 * SJL
normal embryo phenotype J:137456
normal mortality/aging J:137456
Fzr1tm1Mama/Fzr1tm1Mama
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA * SJL
normal embryo phenotype J:137456
normal mortality/aging J:137456
Gli3tm1Alj/Gli3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
abnormal cephalic neural fold morphology J:183402
abnormal forebrain development J:183402
abnormal olfactory epithelium morphology J:183402
decreased embryonic neuroepithelial cell proliferation J:183402
exencephaly J:183402
Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S5/SvEvBrd * C57BL/6 * CBA
embryonic lethality during organogenesis J:152906
Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
embryonic lethality J:194078
hemorrhage J:194078
pallor J:194078
Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
abnormal embryo development J:194078
embryonic lethality during organogenesis, complete penetrance J:194078
Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
no abnormal phenotype detected J:194078
Gt(ROSA)26Sortm6(Vegfa*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
embryonic lethality J:194078
Gt(ROSA)26Sortm8(Aifm1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
normal mortality/aging J:194078
Gt(ROSA)26Sortm9(Aifm1*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
normal mortality/aging J:194078
Gt(ROSA)26Sortm10(Gata2)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
embryonic lethality J:194078
Gt(ROSA)26Sortm11(Gata3)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
normal mortality/aging J:194078
Gt(ROSA)26Sortm14Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
normal mortality/aging J:194078
Gt(ROSA)26Sortm16Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
normal cellular phenotype J:195147
Hcfc1tm1Lwh/Hcfc1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
abnormal embryo morphology J:231596
abnormal extraembryonic tissue morphology J:231596
decreased body length J:231596
decreased cell proliferation J:231596
decreased embryo size J:231596
decreased lean body mass J:231596
embryonic lethality prior to organogenesis J:231596
embryonic lethality, complete penetrance J:231596
increased apoptosis J:231596
Hcfc1tm1Lwh/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
decreased embryo size J:231596
embryonic lethality prior to organogenesis J:231596
embryonic lethality, complete penetrance J:231596
Hcfc1tm1Lwh/Hcfc1tm1Lwh
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
abnormal embryo morphology J:231596
abnormal extraembryonic tissue morphology J:231596
decreased cell proliferation J:231596
decreased embryo size J:231596
embryonic lethality prior to organogenesis J:231596
embryonic lethality, complete penetrance J:231596
increased apoptosis J:231596
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA
abnormal angiogenesis J:154020
abnormal aorta smooth muscle morphology J:154020
embryonic growth retardation J:154020
prenatal lethality, complete penetrance J:154020
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal vascular development J:201133
embryonic growth retardation J:201133
enlarged heart J:201133
internal hemorrhage J:201133
open neural tube J:201133
prenatal lethality J:201133
Kdm6atm1c(EUCOMM)Wtsi/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)
normal mortality/aging J:201868
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)
lethality throughout fetal growth and development, complete penetrance J:201868
Lama1tm1.1Arhi/Lama1tm1.2Arhi
Edil3Tg(Sox2-cre)1Amc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal Bergmann glial cell morphology J:184432
abnormal brain meninges morphology J:184432
abnormal brain pia mater morphology J:184432
abnormal cerebellar foliation J:184432
abnormal cerebellar granule layer morphology J:184432
abnormal cerebellar Purkinje cell layer J:184432
abnormal cerebellum morphology J:184432
abnormal Purkinje cell dendrite morphology J:184432
abnormal radial glial cell morphology J:184432
impaired coordination J:184432
limb grasping J:184432
normal mortality/aging J:184432
short stride length J:184432
small cerebellum J:184432
Lama1tm1Olf/Lama1tm1Olf
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster
abnormal Muller cell morphology J:160722
abnormal ocular fundus morphology J:160722
abnormal retina inner limiting membrane morphology J:160722
abnormal retinal blood vessel morphology J:160722
abnormal retinal blood vessel pattern J:160722
abnormal retinal neuronal layer morphology J:160722
abnormal retinal vasculature morphology J:160722
decreased birth weight J:160722
macrophthalmia J:160722
normal mortality/aging J:160722
persistence of hyaloid vascular system J:160722
normal reproductive system phenotype J:160722
retinal outer nuclear layer degeneration J:160722
retinal spots J:160722
thin retinal inner nuclear layer J:160722
thin retinal inner plexiform layer J:160722
vitreal fibroplasia J:160722
Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA
abnormal endoderm development J:226614
abnormal heart looping J:226614
abnormal heart morphology J:226614
abnormal nervous system development J:226614
abnormal primitive node morphology J:226614
cardia bifida J:226614
cellular necrosis J:226614
embryonic growth retardation J:226614
enlarged pericardium J:226614
Lrp5tm1Kry/Lrp5tm1Kry
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA
abnormal angiogenesis J:154020
abnormal descending aorta morphology J:154020
embryonic growth retardation J:154020
embryonic lethality, incomplete penetrance J:154020
Map2k1tm1Bacc/Map2k1tm1.1Bacc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA
no abnormal phenotype detected J:199705
Map2k1tm1Chrn/Map2k1tm1.1Chrn
Edil3Tg(Sox2-cre)1Amc/?
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N
normal reproductive system phenotype J:112223
Mapk11tm1Jsca/Mapk11+
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA
primary sex reversal J:191096
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal fetal cardiomyocyte proliferation J:176023
abnormal liver morphology J:176023
abnormal neuron proliferation J:176023
exencephaly J:176023
increased hepatocyte apoptosis J:176023
lethality throughout fetal growth and development, complete penetrance J:176023
primary sex reversal J:191096
small liver J:176023
spina bifida J:176023
ventricular septal defect J:176023
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA
normal nervous system phenotype J:176023
postnatal lethality, complete penetrance J:176023
ventricular septal defect J:176023
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
postnatal lethality, incomplete penetrance J:176023
Myctm2.1Atp/Myctm2.1Atp
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal common myeloid progenitor cell morphology J:137630
abnormal proerythroblast morphology J:137630
normal cardiovascular system phenotype J:137630
decreased embryo size J:137630
decreased erythroid progenitor cell number J:137630
embryonic lethality during organogenesis, complete penetrance J:137630
impaired hematopoiesis J:137630
liver hypoplasia J:137630
pale yolk sac J:137630
Nodaltm1Rob/Nodal+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
abnormal embryonic neuroepithelium morphology J:183402
abnormal forebrain development J:183402
abnormal left-right axis patterning J:157256
normal cardiovascular system phenotype J:157256
decreased forebrain size J:183402
embryonic growth retardation J:183402
holoprosencephaly J:183402
rostral body truncation J:183402
Nodaltm1Rob/Nodaltm5Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6
abnormal developmental patterning J:93140
abnormal distal visceral endoderm morphology J:93140
abnormal germ layer development J:93140
absent mesoderm J:93140
Nsdhltm1.1Hrm/Nsdhl+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
abnormal hair growth J:220990
abnormal skeleton morphology J:220990
decreased body size J:220990
hyperkeratosis J:220990
Nsdhltm1.1Hrm/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
postnatal growth retardation J:220990
Nuggctm1Diaz/Nuggctm1Diaz
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * C57BL/6J * CBA
abnormal somatic hypermutation frequency J:190402
normal immune system phenotype J:190402
Pak4tm2.1Amin/Pak4tm2.2Amin
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N
abnormal placenta labyrinth morphology J:152821
abnormal visceral yolk sac morphology J:152821
embryonic growth retardation J:152821
preweaning lethality, complete penetrance J:152821
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA
no abnormal phenotype detected J:173602
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA
increased aorta wall thickness J:173602
postnatal growth retardation J:173602
postnatal lethality, complete penetrance J:173602
Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * C57BL/6 * CBA
abnormal ascending aorta morphology J:173602
abnormal hypodermis fat layer morphology J:173602
abnormal inguinal fat pad morphology J:173602
abnormal mesenteric fat pad morphology J:173602
abnormal white adipose tissue morphology J:173602
abnormal white fat cell differentation J:173602
normal adipose tissue phenotype J:173602
increased white fat cell number J:173602
postnatal growth retardation J:173602
postnatal lethality, complete penetrance J:173602
Pnkptm1.1Pmc/Pnkptm1.1Pmc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * C57BL/6 * CBA
embryonic lethality, complete penetrance J:226703
Porcntm1.1Lcm/Porcn+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal autopod morphology J:173672
abnormal hair follicle development J:173672
abnormal tail morphology J:173672
absent ulna J:173672
caudal body truncation J:173672
cleft palate J:173672
decreased body size J:173672
hairless J:173672
normal integument phenotype J:173672
omphalocele J:173672
perinatal lethality, complete penetrance J:173672
short tail J:173672
sternum hypoplasia J:173672
thin dermal layer J:173672
Porcntm1.1Lcm/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal mesoderm development J:173672
lethality throughout fetal growth and development, complete penetrance J:173672
Prickle1tm1.2Asw/Prickle1tm1.3Asw
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
abnormal hair follicle development J:213772
abnormal hair follicle orientation J:213772
Prickle1tm1.3Asw/Prickle1tm1.3Asw
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
postnatal lethality, complete penetrance J:213772
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc
abnormal sinoatrial node conduction J:256296
increased heart rate J:256296
Psip1tm1Eng/Psip1tm1Eng
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA
abnormal cell physiology J:177408
Ptentm1Ppp/Pten+
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/Sv * C3H * C57BL/6 * CBA
abnormal apoptosis J:173526
abnormal embryo development J:173526
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C3H * C57BL/6 * CBA
abnormal cell adhesion J:173526
abnormal developmental patterning J:173526
abnormal mesoderm development J:173526
abnormal neural tube closure J:173526
abnormal notochordal plate morphology J:173526
abnormal primitive node morphology J:173526
abnormal primitive streak morphology J:173526
cardia bifida J:173526
decreased cell proliferation J:173526
decreased embryo size J:173526
impaired somite development J:173526
increased embryonic tissue cell apoptosis J:173526
prenatal lethality, complete penetrance J:166095
Sall4tm2Tre/Sall4tm2.1Tre
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * CD-1
embryonic growth arrest J:115635
embryonic lethality between implantation and somite formation, complete penetrance J:115635
Shhtm1Chg/Shhtm2Chg
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal carpal bone morphology J:109101
abnormal digit morphology J:109101
abnormal tarsal bone morphology J:109101
perinatal lethality J:125109
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal choroid plexus morphology J:125109
abnormal corpus callosum morphology J:125109
abnormal embryonic/fetal subventricular zone morphology J:125109
abnormal hippocampus development J:125109
abnormal lateral ganglionic eminence morphology J:125109
abnormal maxillary shelf morphology J:125109
abnormal medial ganglionic eminence morphology J:125109
abnormal neurocranium morphology J:125109
abnormal telencephalon development J:125109
abnormal telencephalon morphology J:125109
absent olfactory bulb J:125109
cleft secondary palate J:125109
enlarged brain ventricles J:125109
holoprosencephaly J:125109
increased forebrain size J:125109
increased midbrain size J:125109
palatal shelves fail to meet at midline J:125109
perinatal lethality, complete penetrance J:125109
polydactyly J:109101
Slc13a4tm1c(EUCOMM)Wtsi/Slc13a4tm1d(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
normal embryo phenotype J:239786
lethality throughout fetal growth and development, complete penetrance J:239786
normal mortality/aging J:239786
Smad2tm1Rob/Smad2tm2Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA * CD-1
abnormal anterior definitive endoderm morphology J:84300
abnormal heart looping J:84300
abnormal rostral-caudal axis patterning J:84300
absent forebrain J:84300
absent midbrain J:84300
enlarged pericardium J:84300
pericardial edema J:84300
truncated foregut J:84300
Smad2tm1Rob/Smad2tm2Rob
Smad3tm1Xfw/Smad3+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1
abnormal heart development J:84300
absent foregut J:84300
fused somites J:84300
rostral body truncation J:84300
Smad4tm1Rob/Smad4tm1.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * CD-1
abnormal allantois morphology J:92066
abnormal dorsal-ventral axis patterning J:92066
abnormal hindbrain development J:92066
abnormal rhombomere morphology J:92066
abnormal rostral-caudal axis patterning J:92066
absent foregut J:92066
absent hindgut J:92066
absent primordial germ cells J:92066
embryonic lethality during organogenesis, complete penetrance J:92066
fused somites J:92066
Tlk2tm1.1Strc/Tlk2tm1.2Strc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C3H * C57BL/6
no abnormal phenotype detected J:268910
Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA
abnormal digestive system development J:178936
abnormal lateral plate mesoderm morphology J:178936
abnormal vitelline vasculature morphology J:178936
normal embryo phenotype J:178936
embryonic growth arrest J:178936
short rostral-caudal axis J:178936
wavy neural tube J:178936
Trim33tm1.1Los/Trim33tm1.2Los
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA * SJL
abnormal brain development J:163858
abnormal endoderm development J:163858
abnormal mesendoderm development J:163858
abnormal primitive node morphology J:163858
abnormal primitive streak elongation J:163858
decreased embryo size J:163858
normal embryo phenotype J:163858
embryonic lethality, incomplete penetrance J:163858
incomplete rostral neuropore closure J:163858
Trpm7tm1Clph/Trpm7tm1.1Clph
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA
embryonic lethality, complete penetrance J:140630
Ubr4tm1.2Nkt/Ubr4tm1.2Nkt
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
abnormal atrioventricular cushion morphology J:203460
abnormal brain morphology J:203460
abnormal cell death J:203460
abnormal fourth ventricle morphology J:203460
abnormal head morphology J:203460
abnormal heart development J:203460
abnormal interventricular septum morphology J:203460
abnormal lateral ganglionic eminence morphology J:203460
abnormal liver parenchyma morphology J:203460
abnormal liver vasculature morphology J:203460
abnormal medial ganglionic eminence morphology J:203460
decreased brain size J:203460
normal embryo phenotype J:203460
embryonic growth retardation J:203460
enlarged liver sinusoidal spaces J:203460
increased cell proliferation J:203460
lethality throughout fetal growth and development, complete penetrance J:203460
liver hypoplasia J:203460
thin ventricular wall J:203460
Vps52tm1.1Kab/Vps52tm1.2Kab
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL * C57BL/6 * CBA * DBA
abnormal embryonic tissue morphology J:190873
abnormal vitelline vasculature morphology J:190873
disorganized yolk sac vascular plexus J:190873
embryonic lethality J:190873
Wnt7btm2Amc/Wnt7btm2.1Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129X1/SvJ * C57BL/6 * CBA
abnormal kidney cell proliferation J:142685
abnormal kidney collecting duct epithelium morphology J:142685
abnormal kidney medulla development J:142685
abnormal kidney morphology J:142685
abnormal lung development J:134483
abnormal right lung middle lobe morphology J:134483
abnormal tracheal cartilage morphology J:134483
absent kidney medulla J:142685
atelectasis J:134483
cyanosis J:134483
decreased kidney cell proliferation J:142685
decreased lung weight J:134483
decreased mesenchymal cell proliferation involved in lung development J:134483
hydroureter J:142685
increased kidney apoptosis J:142685
lung hemorrhage J:134483
neonatal lethality, complete penetrance J:134483
small lung J:134483
thin lung-associated mesenchyme J:134483
truncated loop of Henle J:142685
Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
abnormal embryo development J:168015
Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA
abnormal gastrulation J:194989
abnormal heart looping J:194989
abnormal heart morphology J:194989
abnormal neural tube morphology J:194989
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA
abnormal anus morphology J:192577
abnormal axial skeleton morphology J:192577
abnormal direction of heart looping J:192577
abnormal embryo development J:192577
abnormal eye morphology J:192577
abnormal heart looping J:192577
abnormal heart position or orientation J:192577
abnormal inferior vena cava morphology J:192577
abnormal lung position or orientation J:192577
abnormal neural tube morphology J:192577
abnormal stomach position or orientation J:192577
atrial septal defect J:192577
cleft palate J:192577
dextrocardia J:192577
embryonic growth retardation J:192577
exencephaly J:192577
heterotaxia J:192577
hindlimb paralysis J:192577
kinked tail J:192577
lethality throughout fetal growth and development, incomplete penetrance J:192577
right-sided stomach J:192577
ventricular septal defect J:192577

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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory