Dnase2a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dnase2a
deoxyribonuclease II alpha
MGI:1329019

21 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dnase2a^tm1Aea/Dnase2a^tm1Aea involves: 129 * C57BL/6	abnormal apoptosis	J:89469
	abnormal definitive hematopoiesis	J:89469
	anemia	J:89469
	diaphragmatic hernia	J:89469
	perinatal lethality, complete penetrance	J:89469
	thin diaphragm muscle	J:89469
Dnase2a^tm1Osa/Dnase2a^tm1Osa involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal erythropoiesis	J:69831
	abnormal thymus morphology	J:81474
	anemia	J:69831
	decreased erythrocyte cell number	J:69831
	increased nucleated erythrocyte cell number	J:69831, J:81474
	lethality during fetal growth through weaning, complete penetrance	J:69831
	small thymus	J:81474
	thymus hypoplasia	J:81474
Dnase2a^tm1Osa/Dnase2a^tm2Osa Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA	abnormal blood homeostasis	J:114982
	abnormal cytokine level	J:114982
	abnormal macrophage morphology	J:114982
	anemia	J:114982
	increased circulating interleukin-18 level	J:114982
	increased circulating tumor necrosis factor level	J:114982
	joint inflammation	J:114982
	postnatal growth retardation	J:114982
	rheumatoid arthritis	J:114982

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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