58 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ltftm1(icre)Tdku/Ltf+ Smad5tm1Huy/Smad5tm1Huy involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	normal reproductive system phenotype	J:324161
Smad5tm1.1Huy/Smad5tm1.1Huy involves: 129P2/OlaHsd	abnormal allantois morphology	J:86157
	abnormal amnion morphology	J:86157
	abnormal definitive hematopoiesis	J:86157
	abnormal extraembryonic tissue morphology	J:86157
	abnormal foregut morphology	J:86157
	abnormal heart development	J:86157
	abnormal vasculogenesis	J:86157
	abnormal visceral yolk sac morphology	J:86157
	dilated dorsal aorta	J:86157
	failure of initiation of embryo turning	J:86157
	incomplete rostral neuropore closure	J:86157
	pale yolk sac	J:86157
Smad5tm1Cxd/Smad5tm1Cxd either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss)	abnormal dorsal aorta morphology	J:53289
	abnormal embryonic hematopoiesis	J:53289
	abnormal mesoderm development	J:53289
	abnormal rostral-caudal axis patterning	J:53289
	abnormal sclerotome morphology	J:53289
	abnormal spinal cord morphology	J:53289
	abnormal vascular development	J:53289
	abnormal vascular endothelial cell morphology	J:53289
	abnormal vitelline vascular remodeling	J:53289
	abnormal vitelline vasculature morphology	J:53289
	absent forebrain	J:53289
	absent vitelline blood vessels	J:53289
	decreased angiogenesis	J:53289
	decreased embryo size	J:53289
	delayed chorioallantoic fusion	J:53289
	disorganized yolk sac vascular plexus	J:53289
	embryonic growth retardation	J:53289
	embryonic lethality during organogenesis, complete penetrance	J:53289
	hemorrhage	J:53289
	incomplete embryo turning	J:53289
	increased apoptosis	J:53289
	pale yolk sac	J:53289
	vascular smooth muscle hypotrophy	J:53289
Smad5tm1Huy/Smad5tm1.1Huy Tg(Tagln-cre)1Her/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL	decreased cardiac muscle contractility	J:121072
	dilated heart	J:121072
	impaired exercise endurance	J:121072
Smad5tm1Huy/Smad5tm1.1Huy Tg(Tek-cre)1Ywa/0 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL	normal cardiovascular system phenotype	J:121072
Smad5tm1Huy/Smad5tm1.1Huy Tg(Tie1-cre)9Ref/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	normal cardiovascular system phenotype	J:121072
Smad5tm1Huy/Smad5tm1Huy involves: 129P2/OlaHsd	no abnormal phenotype detected	J:86157
Smad5tm1Zuk/Smad5+ involves: 129S7/SvEvBrd * C57BL/6	decreased litter size	J:70069
	decreased primordial germ cell number	J:70069
	reduced fertility	J:70069
Smad5tm1Zuk/Smad5tm1Zuk involves: 129S7/SvEvBrd * C57BL/6	abnormal allantois morphology	J:53293
	abnormal amnion morphology	J:53293
	abnormal blood vessel morphology	J:53293
	abnormal brain development	J:53293
	abnormal digestive system development	J:53293
	abnormal embryo development	J:53293
	abnormal embryo turning	J:53293, J:60975
	abnormal embryonic tissue morphology	J:53293
	abnormal heart tube morphology	J:60975
	abnormal left-right axis patterning	J:60975
	abnormal pharyngeal arch morphology	J:53293
	abnormal ventral body wall morphology	J:53293
	abnormal vitelline vascular remodeling	J:53293
	decreased embryo size	J:53293
	decreased primordial germ cell number	J:70069
	delayed heart development	J:53293, J:60975
	delayed neural tube closure	J:53293
	edema	J:53293
	embryonic growth retardation	J:53293
	embryonic lethality during organogenesis, complete penetrance	J:53293
	exencephaly	J:53293
	failure of heart looping	J:60975
	pale yolk sac	J:53293