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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfrsf1b
tumor necrosis factor receptor superfamily, member 1b
MGI:1314883
72 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Birc2tm1.1Rbr/Birc2tm1.1Rbr
Birc3tm1.1Rbr/Birc3tm1.1Rbr
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL 		embryonic lethality during organogenesis, complete penetrance J:182515
Ifngtm1Ts/Ifngtm1Ts
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
increased eosinophil cell number J:119206
increased leukocyte cell number J:119206
increased lymphocyte cell number J:119206
increased susceptibility to fungal infection J:119206
lung inflammation J:119206
small Peyer's patches J:119206
Krt8tm1Rgo/Krt8tm1Rgo
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, incomplete penetrance J:121811
Lepob/Lepob
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6 		abnormal adipose tissue morphology J:55722
abnormal metabolism J:55722
decreased circulating insulin level J:55722
Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6J * NOD 		increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Tg(Tnf)6074Gkl/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6 * CBA 		abnormal oligodendrocyte apoptosis J:106592
CNS inflammation J:106592
demyelination J:106592
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		rheumatoid arthritis J:54056
small intestinal inflammation J:54056
Tnftm2Gkl/Tnf+
Tnfrsf1btm1.1Gkl/Tnfrsf1btm1.1Gkl
Tg(Col6a1-cre)1Gkl/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		abnormal cell adhesion J:264147
abnormal cell physiology J:264147
abnormal fibroblast physiology J:264147
abnormal wound healing J:264147
normal cardiovascular system phenotype J:264147
increased circulating tumor necrosis factor level J:264147
increased tumor necrosis factor secretion J:264147
joint inflammation J:264147
Tnftm2Gkl/Tnf+
Tnfrsf1btm1.2Gkl/Tnfrsf1btm1.2Gkl
involves: 129S/SvEv * C57BL/6 * C57BL/6J 		abnormal cell adhesion J:264147
abnormal cell physiology J:264147
abnormal fibroblast physiology J:264147
abnormal wound healing J:264147
aortic valve inflammation J:264147
aortic valve stenosis J:264147
arthritis J:264147
cardiac fibrosis J:264147
increased circulating tumor necrosis factor level J:264147
increased tumor necrosis factor secretion J:264147
Tnfaip8l1em1Huwa/Tnfaip8l1em1Huwa
Tnfrsf1aem2Smoc/Tnfrsf1aem2Smoc
Tnfrsf1bem1Smoc/Tnfrsf1bem1Smoc
C57BL/6-Tnfrsf1bem1Smoc Tnfrsf1aem2Smoc Tnfaip8l1em1Huwa 		normal digestive/alimentary phenotype J:342074
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129/Sv * C57BL/6 		liver inflammation J:92470
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		abnormal lymph node cortex morphology J:119206
abnormal lymph node primary follicle morphology J:119206
abnormal lymph node secondary follicle morphology J:119206
absent lymph node germinal center J:119206
absent spleen germinal center J:119206
decreased IgG1 level J:115225
decreased susceptibility to experimental autoimmune encephalomyelitis J:115225
normal immune system phenotype J:119206
increased susceptibility to parasitic infection J:114203
small Peyer's patches J:119206
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
B6.129S-Tnfrsf1btm1Imx Tnfrsf1atm1Imx/J 		decreased susceptibility to Coronaviridae infection J:288523
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
involves: 129S7/SvEvBrd * C57BL/6 		abnormal body temperature homeostasis J:48865
abnormal bone healing J:70467
abnormal glial cell physiology J:78637
abnormal kidney morphology J:69294
abnormal nervous system morphology J:78637
abnormal neuron physiology J:33864
abnormal retina blood vessel morphology J:104652
abnormal thrombosis J:117987
abnormal trabecular bone morphology J:70467
decreased food intake J:48865
decreased inflammatory response J:45147
decreased microglial cell activation J:33864
decreased physiological sensitivity to xenobiotic J:51349
decreased susceptibility to dopaminergic neuron neurotoxicity J:78637
decreased susceptibility to endotoxin shock J:45147
decreased susceptibility to experimental autoimmune uveoretinitis J:115094
decreased susceptibility to induced arthritis J:120707
decreased susceptibility to induced morbidity/mortality J:48865
dental pulp necrosis J:58851
impaired skeletal muscle regeneration J:104990
increased bone resorption J:58851
increased cerebral infarct size J:33864
increased circulating tumor necrosis factor level J:45147
increased myocardial infarct size J:62223
increased susceptibility to bacterial infection J:58851
increased susceptibility to neuronal excitotoxicity J:33864
normal nervous system phenotype J:33864
osteomyelitis J:58851
pulmonary fibrosis J:51349
renal interstitial fibrosis J:69294
seizures J:112713
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04/16/2024
MGI 6.23 		The Jackson Laboratory