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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hus1
HUS1 checkpoint clamp component
MGI:1277962
31 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hus1tm1.1Rsw/Hus1tm1.1Rsw
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		abnormal developmental patterning J:99339
abnormal embryo turning J:99339
abnormal neural tube morphology J:99339
abnormal somite development J:99339
abnormal vitelline vasculature morphology J:99339
decreased embryo size J:99339
embryonic growth arrest J:99339
embryonic growth retardation J:99339
embryonic lethality during organogenesis, complete penetrance J:99339
failure of chorioallantoic fusion J:99339
incomplete rostral neuropore closure J:99339
increased embryonic tissue cell apoptosis J:99339
kinked neural tube J:99339
Hus1tm1Led/Hus1tm1Led
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		abnormal allantois morphology J:63869
abnormal embryonic hematopoiesis J:63869
abnormal placenta labyrinth morphology J:63869
abnormal placental labyrinth vasculature morphology J:63869
abnormal somite development J:63869
abnormal somite shape J:63869
abnormal visceral yolk sac blood island morphology J:63869
abnormal visceral yolk sac morphology J:63869
abnormal vitelline vasculature morphology J:63869
absent fibroblast proliferation J:63869
absent limb buds J:63869
chromosome breakage J:63869
decreased embryo size J:63869
embryonic growth retardation J:63869
embryonic lethality during organogenesis, complete penetrance J:63869
failure of chorioallantoic fusion J:63869
failure of initiation of embryo turning J:63869
incomplete rostral neuropore closure J:63869
increased embryonic tissue cell apoptosis J:63869
kinked neural tube J:63869
Hus1tm1Led/Hus1tm1Led
involves: 129S6/SvEvTac 		abnormal developmental patterning J:99339
abnormal neural tube morphology J:99339
decreased embryo size J:99339
embryonic growth retardation J:99339
increased embryonic tissue cell apoptosis J:99339
Hus1tm1Led/Hus1tm1Rsw
Tg(Hsp70-1-cre)1Arge/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * CBA 		prenatal lethality, incomplete penetrance J:99339
Hus1tm1Led/Hus1tm2Rsw
involves: 129S6/SvEvTac * C57BL/6 		abnormal cell cycle checkpoint function J:118898
abnormal cell physiology J:118898
abnormal chromosome morphology J:118898
chromosome breakage J:118898
decreased cell proliferation J:118898
induced chromosome breakage J:118898
oxidative stress J:118898
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory