Pycr2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pycr2
pyrroline-5-carboxylate reductase family, member 2
MGI:1277956

49 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pycr2^m1J/Pycr2^m1J involves: C3H/HeJ * C57BL/6J	abnormal axon morphology	J:308336
	abnormal gait	J:308336
	decreased basophil cell number	J:308336
	decreased body weight	J:308336
	decreased circulating cholesterol level	J:308336
	decreased circulating glutamic acid level	J:308336
	decreased circulating HDL cholesterol level	J:308336
	decreased circulating potassium level	J:308336
	decreased circulating triglyceride level	J:308336
	decreased grip strength	J:308336
	decreased leukocyte cell number	J:308336
	decreased lymphocyte cell number	J:308336
	decreased subcutaneous adipose tissue amount	J:308336
	decreased total body fat amount	J:308336
	normal homeostasis/metabolism phenotype	J:308336
	increased blood urea nitrogen level	J:308336
	increased myelin sheath thickness	J:308336
	kyphosis	J:308336
	limb grasping	J:308336
	normal nervous system phenotype	J:308336
	renal glomerulus lipidosis	J:308336
	normal skeleton phenotype	J:308336
	thin body	J:308336
	thin skin	J:308336
Pycr2^m1J/Pycr2^m1J Pycr2^m1J/Pycr2^m1J involves: C3H/HeJ * C57BL/6J * C57BL/6NTac	decreased body size	J:308336
	preweaning lethality, incomplete penetrance	J:308336
Pycr2^tm1.1Brre/Pycr2^tm1.1Brre involves: C57BL/6	abnormal amino acid level	J:296329
	abnormal neuron morphology	J:296329
	abnormal oligodendrocyte apoptosis	J:296329
	abnormal oligodendrocyte morphology	J:296329
	axonal dystrophy	J:296329
	axonal spheroids	J:296329
	decreased body mass index	J:296329
	decreased corpus callosum size	J:296329
	hippocampal neuron degeneration	J:296329
	impaired balance	J:296329
	impaired coordination	J:296329
	impaired neuron differentiation	J:296329
	increased neuron apoptosis	J:296329
	kyphosis	J:296329
	limb grasping	J:296329
	neuron degeneration	J:296329
	premature death	J:296329
	weight loss	J:296329
Pycr2^{tm1a(EUCOMM)Wtsi}/Pycr2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Pycr2^{tm1a(EUCOMM)Wtsi}/Wtsi	absent pinna reflex	J:211773
	decreased bone mineral density	J:211773
	decreased Ly6C low monocyte number	J:211773
	decreased monocyte cell number	J:211773
	increased fasting circulating glucose level	J:211773
	increased mean corpuscular hemoglobin	J:211773
	limb grasping	J:211773
	trunk curl	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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