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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Casp8
caspase 8
MGI:1261423
49 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Casp8tm1.1Raz/Casp8tm1.1Raz
Ripk3tm1Vmd/Ripk3+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
abnormal visceral yolk sac blood island morphology J:170815
abnormal vitelline vasculature morphology J:170815
embryonic growth arrest J:170815
embryonic lethality, complete penetrance J:170815
Casp8tm1.1Raz/Casp8tm1.1Raz
Ripk3tm1Vmd/Ripk3tm1Vmd
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
abnormal liver physiology J:170815
abnormal macrophage physiology J:170815
decreased hepatocyte apoptosis J:170814
decreased macrophage apoptosis J:170815
decreased thymocyte apoptosis J:170814
enlarged axillary lymph nodes J:170815
enlarged cervical lymph nodes J:170815
enlarged lymph nodes J:170814
enlarged spleen J:170814, J:170815
enlarged thymus J:170814
normal growth/size/body region phenotype J:170814
normal hematopoietic system phenotype J:170814, J:170815
normal immune system phenotype J:170815
increased B cell number J:170815
increased inflammatory response J:170815
increased leukocyte cell number J:170815
increased spleen white pulp amount J:170815
increased T cell number J:170814, J:170815
large lymphoid organs J:170814
lymph node hyperplasia J:170815
normal mortality/aging J:170814, J:170815
Casp8tm1.1Vmd/Casp8+
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N
lethality throughout fetal growth and development, complete penetrance J:209137
Casp8tm1.1Vmd/Casp8tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd
involves: C57BL/6N
enlarged lymph nodes J:209137
enlarged spleen J:209137
increased T cell number J:209137
normal mortality/aging J:209137
Casp8tm1Clie/Casp8tm1Clie
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
abnormal biliary tract morphology J:218665
abnormal circulating enzyme level J:218665
abnormal liver morphology J:218665
decreased body size J:218665
enlarged liver J:218665
hepatic necrosis J:218665
increased bile salt level J:218665
increased circulating alkaline phosphatase level J:218665
increased circulating bilirubin level J:218665
intrahepatic cholestasis J:218665
liver fibrosis J:218665
normal neoplasm J:218665
Casp8tm1Clie/Casp8tm1Clie
Map3k7tm1Aki/Map3k7tm1Aki
Tg(Alb1-cre)7Gsc/0
involves: 129P2/OlaHsd * FVB/N
abnormal bile duct morphology J:160521
abnormal liver morphology J:160521
bile duct proliferation J:160521
focal hepatic necrosis J:160521
increased circulating alanine transaminase level J:160521
increased circulating aspartate transaminase level J:160521
increased circulating bilirubin level J:160521
normal mortality/aging J:160521
postnatal growth retardation J:160521
Casp8tm1Syon/Casp8tm1Syon
Tg(Myh7-BVp35-EGFP)#Ksa/?
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
abnormal neural tube morphology J:102279
abnormal vitelline vasculature morphology J:102279
normal cardiovascular system phenotype J:102279
embryonic lethality during organogenesis, complete penetrance J:102279
hemopericardium J:102279
increased cardiomyocyte apoptosis J:102279

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory