35 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Acvr1tm1Mak/Acvr1+ Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Olig2tm1.1(cre)Wdr/Olig2+ involves: 129 * C57BL/6 * FVB/N	increased brain tumor incidence	J:285841
	increased glioma incidence	J:285841
Acvr1tm1Mak/Acvr1+ Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ H3c2tm1Mak/H3c2+ Olig2tm1.1(cre)Wdr/Olig2+ involves: 129 * C57BL/6 * FVB/N	increased brain tumor incidence	J:285841
	increased glioma incidence	J:285841
Arid1atm1.1Mag/Arid1a+ Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * CD-1	abnormal ovary morphology	J:219794
	normal neoplasm	J:219794
Arid1atm1.1Mag/Arid1atm1.1Mag Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * CD-1	hemorrhagic ascites	J:219794
	increased interleukin-6 secretion	J:219794
	increased metastatic potential	J:219794
	increased ovarian carcinoma incidence	J:219794
	increased ovary tumor incidence	J:219794
Ctnnb1tm1Mmt/Ctnnb1+ Pik3catm1Gilb/Pik3ca+ Trp53tm1Brn/Trp53+ Tg(Fabp7-cre,-lacZ)3Gtm/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	increased medulloblastoma incidence	J:186709
Egr2tm2(cre)Pch/Egr2+ Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/? Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	abnormal myelination	J:207470
Erbb3tm3Cbm/Erbb3tm3Cbm Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/? Tg(Dhh-cre)1Mejr/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal myelination	J:207470
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Trp53tm1Brn/Trp53tm1Brn Tg(MMTV-cre)#Tfln/0 involves: 129P2/OlaHsd * 129S6/SvEvTac	increased lymphoma incidence	J:170898
	increased mammary gland tumor incidence	J:170898
	increased T cell derived lymphoma incidence	J:170898
	premature death	J:170898
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ Tg(MMTV-cre)#Tfln/0 Trp53tm1Brn/Trp53+ involves: 129P2/OlaHsd * 129S6/SvEvTac	increased lymphoma incidence	J:170898
	increased mammary adenocarcinoma incidence	J:170898
	increased mammary gland tumor incidence	J:170898
	increased T cell derived lymphoma incidence	J:170898
	premature death	J:170898
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+ H3c2tm1Mak/H3c2+ Olig2tm1.1(cre)Wdr/Olig2+ involves: 129 * C57BL/6 * FVB/N	normal neoplasm	J:285841
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+ Krastm4Tyj/Kras+ Pdpk1tm1Mlw/Pdpk1tm1Mlw Ptf1atm1(cre)Hnak/Ptf1a+ involves: 129S4/SvJae * 129S6/SvEvTac	normal endocrine/exocrine gland phenotype	J:197054
	normal neoplasm	J:197054
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+ Pdpk1tm1Mlw/Pdpk1tm1Mlw Ptf1atm1(cre)Hnak/Ptf1a+ involves: 129S6/SvEvTac	normal endocrine/exocrine gland phenotype	J:197054
	normal neoplasm	J:197054
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky Ighg1tm1(cre)Cgn/Ighg1+ involves: 129P2/OlaHsd * C57BL/6	abnormal class switch recombination	J:191824
	increased B cell derived lymphoma incidence	J:191824
	increased germinal center B cell number	J:191824
	premature death	J:191824
Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/? Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm Tg(Dhh-cre)1Mejr/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal myelination	J:207470
Krastm3Tyj/Kras+ Pik3catm1Jdo/Pik3catm1Jdo involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	decreased incidence of induced tumors	J:122866
	decreased lung tumor incidence	J:122866
Pik3catm1.1Waph/Pik3ca+ Ptentm1Hwu/Ptentm1Hwu involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6	abnormal diaphragm morphology	J:184382
	abnormal ovary morphology	J:184382
	abnormal ovary physiology	J:184382
	abnormal peritoneum morphology	J:184382
	hemorrhagic ascites	J:184382
	increased adenocarcinoma incidence	J:184382
	increased granulosa cell tumor incidence	J:184382
	increased ovary tumor incidence	J:184382
	ovary hemorrhage	J:184382
	premature death	J:184382
Pik3catm1Jjz/Pik3catm1Jjz Pik3cbtm1Jjz/Pik3cbtm1Jjz Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre)#Smr/0 FVB.Cg-Pik3catm1Jjz Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr	normal integument phenotype	J:199362
Pik3catm1Jjz/Pik3catm1Jjz Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre)#Smr/0 FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr	increased skin hamartoma incidence	J:199362
	skin lesions	J:199362
	thick epidermis stratum basale	J:199362
	thick skin	J:199362
Pik3catm1Nbm/Pik3ca+ Pik3cbtm1Nbm/Pik3cb+ involves: 129S6/SvEvTac	impaired glucose tolerance	J:96761
	increased circulating insulin level	J:96761