Chek1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chek1
checkpoint kinase 1
MGI:1202065

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Chek1^tm1Sje/Chek1⁺ Tg(Wnt1)1Hev/0 Not Specified	increased mammary adenocarcinoma incidence	J:62919
Chek1^tm1Sje/Chek1^tm1Sje Trp53^tm1Brd/Trp53^tm1Brd involves: 129S7/SvEvBrd	embryonic lethality before implantation, complete penetrance	J:62919
	increased apoptosis	J:62919
Chek1^tm2.1Sje/Chek1⁺ Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)#Mam/0 involves: 129P2/OlaHsd * FVB	abnormal branching of the mammary ductal tree	J:162126
	abnormal chromosome morphology	J:162126
	abnormal mammary gland alveolus morphology	J:162126
	abnormal tumor morphology	J:162126
	abnormal tumor vascularization	J:162126
	aneuploidy	J:162126
	increased mammary adenocarcinoma incidence	J:162126
	increased mammary gland tumor incidence	J:162126
	mammary gland hyperplasia	J:162126
Chek1^tm2.1Sje/Chek1⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0 involves: 129P2/OlaHsd * FVB	abnormal mammary gland alveolus morphology	J:162126
	decreased tumor incidence	J:162126
	increased mammary gland tumor incidence	J:162126
	mammary gland hyperplasia	J:162126
Chek1^tm2.1Sje/Chek1^tm2.1Sje Trp53^tm1Brn/Trp53⁺ Tg(MMTV-cre)#Mam/0 involves: 129P2/OlaHsd * FVB	abnormal mammary gland alveolus morphology	J:162126
	increased mammary gland tumor incidence	J:162126
Chek1^tm2.1Sje/Chek1^tm2.1Sje Trp53^tm1Brn/Trp53^tm1Brn Tg(MMTV-cre)#Mam/0 involves: 129P2/OlaHsd * FVB	abnormal mammary gland alveolus morphology	J:162126
	abnormal tumor morphology	J:162126
	decreased tumor incidence	J:162126
	normal reproductive system phenotype	J:162126
Mcm3^tm1.1Geno/Mcm3^tm1.1Geno Tg(Chek1)1Ofc/0 involves: 129S2/SvPas * C57BL/6 * CD-1	prenatal lethality, incomplete penetrance	J:227638

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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