Casz1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Casz1
castor zinc finger 1
MGI:1196251

46 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Casz1^{Gt(CJ0565)Wtsi}/Casz1^{Gt(CJ0565)Wtsi} involves: 129P2/OlaHsd * C57BL/6	abnormal blood circulation	J:242127
	abnormal heart development	J:242127
	abnormal interventricular septum morphology	J:242127
	abnormal lymphatic vessel morphology	J:242127
	abnormal myocardium compact layer morphology	J:242127
	abnormal sarcomere morphology	J:242127
	abnormal Z line morphology	J:242127
	congestive heart failure	J:242127
	decreased fetal cardiomyocyte proliferation	J:242127
	enlarged lymphatic vessel	J:242127
	fetal cardiomyocyte disarray	J:242127
	globular heart	J:242127
	lethality throughout fetal growth and development, complete penetrance	J:242127
	liver vascular congestion	J:242127
	myocardium hypoplasia	J:242127
	nuchal edema	J:242127
	subcutaneous edema	J:242127
	thin interventricular septum	J:242127
	thin myocardium	J:242127
	ventricular myocardium compact layer hypoplasia	J:242127
	ventricular septal defect	J:242127
Casz1^tm1.1Flc/Casz1⁺ Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	no abnormal phenotype detected	J:221324
Casz1^tm1.1Flc/Casz1^tm1.1Flc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL	abnormal heart development	J:221324
	embryonic lethality during organogenesis, complete penetrance	J:221324
	heart hypoplasia	J:221324
	thin ventricular wall	J:221324
	ventricular septal defect	J:221324
Casz1^tm1.1Flc/Casz1^tm1.1Flc Isl1^tm1(cre)Tmj/Isl1⁺ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL	abnormal heart right ventricle morphology	J:221324
	abnormal heart shape	J:221324
	decreased mitotic index	J:221324
	heart right ventricle hypoplasia	J:221324
	lethality throughout fetal growth and development, complete penetrance	J:221324
Casz1^tm1.1Flc/Casz1^tm1.1Flc Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	abnormal cell cycle checkpoint function	J:221324
	abnormal fetal cardiomyocyte physiology	J:221324
	abnormal heart apex morphology	J:221324
	abnormal heart development	J:221324
	abnormal heart left ventricle morphology	J:221324
	abnormal heart shape	J:221324
	abnormal heart ventricle morphology	J:221324
	abnormal interventricular septum morphology	J:221324
	decreased fetal cardiomyocyte number	J:221324
	decreased fetal cardiomyocyte proliferation	J:221324
	decreased mitotic index	J:221324
	dilated heart right atrium	J:221324
	distended pericardium	J:221324
	edema	J:221324
	embryonic lethality during organogenesis, complete penetrance	J:221324
	heart hypoplasia	J:221324
	hemorrhage	J:221324
	increased heart right atrium size	J:221324
	perimembraneous ventricular septal defect	J:221324
	poor circulation	J:221324
	thin myocardium	J:221324
	thin ventricular wall	J:221324
	trabecula carnea hypoplasia	J:221324
Casz1^{tm1b(EUCOMM)Hmgu}/Casz1⁺ C57BL/6N-Casz1^{tm1b(EUCOMM)Hmgu}/H	persistence of hyaloid vascular system	J:211773
	shortened QT interval	J:211773
Casz1^{tm1b(EUCOMM)Hmgu}/Casz1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Casz1^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, complete penetrance	J:211773
Casz1^{tm2(cre/ERT2)Flc}/Casz1⁺ involves: 129P2/OlaHsd	no abnormal phenotype detected	J:221324

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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