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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mre11a
MRE11A homolog A, double strand break repair nuclease
MGI:1100512
12 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lig4tm1Icrf/Lig4tm1Icrf
Mre11atm1Jpt/Mre11atm1Jpt
involves: 129 * 129S7/SvEvBrd 		decreased cellular sensitivity to ionizing radiation J:144172
neonatal lethality, complete penetrance J:144172
Lig4tm1Pmc/Lig4tm1Pmc
Mre11atm1Jpt/Mre11atm1Jpt
Tg(Nes-cre)1Kln/0
involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL 		ataxia J:144172
normal nervous system phenotype J:144172
Mre11atm1Jpt/Mre11a+
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal hematopoietic system morphology/development J:103922
anemia J:103922
increased lymphoma incidence J:103922
premature death J:103922
Mre11atm1Jpt/Mre11atm1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle checkpoint function J:103922
chromosome breakage J:103922
normal hematopoietic system phenotype J:103922
increased cellular sensitivity to ionizing radiation J:103922
increased lymphoma incidence J:103922
premature death J:103922
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory