Mre11a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mre11a
MRE11A homolog A, double strand break repair nuclease
MGI:1100512

23 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mre11a^tm1.1Rchd/Mre11a^tm1.1Rchd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cell cycle checkpoint function	J:184053
	abnormal class switch recombination	J:184053
	chromosomal instability	J:184053
	increased mitotic index	J:184053
	increased mortality induced by gamma-irradiation	J:184053
	normal mortality/aging	J:184053
	normal reproductive system phenotype	J:184053
Mre11a^tm1Dof/Mre11a^tm1Dof involves: 129S6/SvEvTac	abnormal embryo development	J:147247
	abnormal heart development	J:147247
	embryonic growth arrest	J:147247
	embryonic lethality during organogenesis, complete penetrance	J:147247
Mre11a^tm1Dof/Mre11a^tm2.1Dof involves: 129S6/SvEvTac	abnormal DNA repair	J:147247
	normal cellular phenotype	J:147247
	chromosomal instability	J:147247
	decreased cell proliferation	J:147247
	increased cellular sensitivity to ionizing radiation	J:147247
	induced chromosome breakage	J:147247
Mre11a^tm1Jpt/Mre11a^tm1Jpt involves: 129S7/SvEvBrd	decreased cellular sensitivity to ionizing radiation	J:144172
Mre11a^tm1Jpt/Mre11a^tm1Jpt involves: 129S7/SvEvBrd * C57BL/6	abnormal cell cycle checkpoint function	J:87088, J:103922
	chromosomal instability	J:87088
	chromosome breakage	J:103922
	increased cellular sensitivity to ionizing radiation	J:87088, J:103922
	induced chromosome breakage	J:87088
	maternal effect	J:87088
	normal neoplasm	J:87088
	reduced female fertility	J:87088
Mre11a^tm2.1Dof/Mre11a^tm2.2Dof Not Specified	abnormal cell cycle checkpoint function	J:147247
	abnormal DNA repair	J:147247
	chromosomal instability	J:147247
	decreased cell proliferation	J:147247
	increased cellular sensitivity to ionizing radiation	J:147247
	induced chromosome breakage	J:147247
	spontaneous chromosome breakage	J:147247
Mre11a^tm3.1Dof/Mre11a^tm3.1Dof involves: 129 * C57BL/6	embryonic lethality, complete penetrance	J:268252

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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