Tnfsf11 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd40^tm1Kik/Cd40^tm1Kik Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd	abnormal thymus epithelium morphology	J:173115
Ltbr^tm1Mmat/Ltbr^tm1Mmat Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal thymus epithelium morphology	J:173115
Tg(APCS-Tnfsf11)#aKhs/0 C57BL/6J-Tg(APCS-Tnfsf11)#aKhs	abnormal osteoclast morphology	J:264357
	decreased bone mineral density of femur	J:264357
	decreased bone stiffness	J:264357
	decreased bone strength	J:264357
	decreased trabecular bone mass	J:264357
	enlarged thymus medulla	J:264357
	fragile skeleton	J:264357
	increased bone resorption	J:264357
	increased circulating alkaline phosphatase level	J:264357
	increased osteoclast cell number	J:264357
	osteoporosis	J:264357
	perinatal lethality, incomplete penetrance	J:264357
	postnatal lethality, incomplete penetrance	J:264357
	skin edema	J:264357
Tg(APCS-Tnfsf11)#bKhs/0 involves: C3H/He C57BL/6N	decreased trabecular bone mass	J:264357
Tg(APCS-Tnfsf11)#bKhs/0 involves: C3H/He C57BL/6N	osteoporosis	J:264357
Tg(Bglap2-TAg)1Rkho/0 Tnfsf11^tm1Pngr/Tnfsf11⁺ involves: 129P2/OlaHsd * FVB/N	increased osteosarcoma incidence	J:234128
Tg(Bglap2-TAg)1Rkho/0 Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr involves: 129P2/OlaHsd * FVB/N	abnormal femur morphology	J:234128
	decreased osteosarcoma incidence	J:234128
Tg(CAG-Tnfsf11)#Khs/0 either: (involves: C57BL/6N) or (involves: C3H/He C57BL/6J)	decreased bone mineralization	J:264357
	distended abdomen	J:264357
	perinatal lethality, complete penetrance	J:264357
Tg(TNFSF11)5516Edou/0 Tnfsf11^tles/Tnfsf11^tles involves: 129S6/SvEvTac * C57BL/6J * CBA/J	abnormal tooth eruption	J:233240
	absent lymph nodes	J:233240
	normal mortality/aging	J:233240
	normal skeleton phenotype	J:233240
Tg(TNFSF11)5519Edou/0 Tnfsf11^tles/Tnfsf11^tles involves: 129S6/SvEvTac * C57BL/6J * CBA/J	no abnormal phenotype detected	J:233240

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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