Hdac2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hdac2
histone deacetylase 2
MGI:1097691

48 phenotypes from 8 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hdac2^{em1(IMPC)Kmpc}/Hdac2^{em1(IMPC)Kmpc} C57BL/6NTac-Hdac2^{em1(IMPC)Kmpc}/Kmpc	preweaning lethality, complete penetrance	J:211773
Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe} involves: 129S2/SvPas	abnormal intestinal mucosa morphology	J:152134
	abnormal large intestine crypts of Lieberkuhn morphology	J:152134
	abnormal pelvic girdle bone morphology	J:152134
	decreased body weight	J:152134
	decreased brain weight	J:152134
	decreased intestine length	J:152134
	decreased survivor rate	J:152134
	embryonic lethality during organogenesis, incomplete penetrance	J:152134
	insensitivity to growth hormone	J:152134
	small testis	J:152134
	small vertebrae	J:152134
Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe} Not Specified	abnormal cardiovascular system morphology	J:121697
	abnormal cardiovascular system physiology	J:121697
	abnormal myocardial fiber morphology	J:121697
	abnormal myocardial trabeculae morphology	J:121697
	abnormal myocardium layer morphology	J:121697
	normal cardiovascular system phenotype	J:121697
	decreased body size	J:121697
	diffuse Z line	J:121697
	enlarged heart	J:121697
	increased fetal cardiomyocyte proliferation	J:121697
	lethargy	J:121697
	postnatal lethality, incomplete penetrance	J:121697
	prenatal lethality, incomplete penetrance	J:121697
	thick myocardium compact layer	J:121697
	thick ventricular wall	J:121697
Hdac2^tm1.1Eno/Hdac2^tm1.1Eno H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129 * C57BL/6 * CBA	no abnormal phenotype detected	J:150709
Hdac2^tm1.1Eno/Hdac2^tm1.1Eno Tg(Myh6-cre)2182Mds/? involves: 129S/SvEv * C57BL/6 * CD-1 * FVB/N	no abnormal phenotype detected	J:123173
Hdac2^tm1.1Shmc/Hdac2^tm1.1Shmc Tg(Lck-cre)1Cwi/0 involves: 129S7/SvEvBrd	normal immune system phenotype	J:194769
Hdac2^tm1.2Eno/Hdac2^tm1.2Eno involves: 129S/SvEv * C57BL/6 * CD-1	abnormal fetal cardiomyocyte proliferation	J:123173
	abnormal heart right ventricle morphology	J:123173
	cyanosis	J:123173
	decreased heart rate	J:123173
	increased cardiomyocyte apoptosis	J:123173
	neonatal lethality, complete penetrance	J:123173
	thick interventricular septum	J:123173
Hdac2^tm1.2Pmt/Hdac2^tm1.2Pmt involves: 129P2/OlaHsd * C57BL/6 * FVB/N	decreased birth body size	J:157903
	perinatal lethality, incomplete penetrance	J:157903
Hdac2^tm1.2Rdp/Hdac2^tm1.2Rdp involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal dentate gyrus morphology	J:148391
	abnormal hippocampus CA1 region morphology	J:148391
	abnormal hippocampus pyramidal cell morphology	J:148391
	decreased body size	J:148391
	enhanced contextual conditioning behavior	J:148391
	enhanced long-term potentiation	J:148391
	prenatal lethality, incomplete penetrance	J:148391
	reduced fertility	J:148391
Hdac2^tm1Lex/Hdac2⁺ involves: 129S5/SvEvBrd * C57BL/6	abnormal eye electrophysiology	J:214041
	abnormal total retina thickness	J:214041
	decreased susceptilbility to retina ischemic injury	J:214041
Hdac2^tm1Lex/Hdac2^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal heart morphology	J:214041
Hdac2^tm1Lex/Hdac2^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	neonatal lethality, complete penetrance	J:214041

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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