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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Fxn
frataxin
MGI:1096879
49 phenotypes from 8 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Fxnem1(IMPC)J/Fxn+
C57BL/6NJ-Fxnem1(IMPC)J/J
abnormal embryo size J:211773
embryonic growth retardation J:211773
Fxnem1(IMPC)J/Fxnem1(IMPC)J
C57BL/6NJ-Fxnem1(IMPC)J/J
embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Fxnem2Lutzy/Fxnem2.1Lutzy
Tg(Ckmm-cre)5Khn/?
B6.Cg-Fxnem2Lutzy Fxnem2.1Lutzy Tg(Ckmm-cre)5Khn/J
cardiomyopathy J:101977
decreased cardiac muscle contractility J:101977
decreased heart rate J:101977
increased left ventricle weight J:101977
premature death J:101977
Fxntm1.1Pand/Fxntm1Mkn
B6.Cg-Fxntm1.1Pand Fxntm1Mkn/J
abnormal mitochondrial biogenesis J:242978
Fxntm1Mkn/Fxntm1Mkn
involves: 129 * C57BL/6J
abnormal extraembryonic tissue morphology J:62185
decreased embryo size J:62185
embryo tissue necrosis J:62185
embryonic growth arrest J:62185
embryonic lethality between implantation and somite formation, complete penetrance J:62185
normal homeostasis/metabolism phenotype J:62185
increased embryonic tissue cell apoptosis J:62185
Fxntm1Mkn/Fxntm1Pand
involves: 129/Sv * C57BL/6
brain inflammation J:216422
cardiac fibrosis J:109164
increased heart iron level J:109164
premature death J:109164
Fxntm2Mkn/Fxntm2.1Mkn
Tg(Ckmm-cre)1Lrsn/0
involves: 129 * C57BL/6J
abnormal iron homeostasis J:75420
abnormal mitochondrion morphology J:75420, J:90401
abnormal myocardial fiber morphology J:75420, J:90401
abnormal respiratory electron transport chain J:75420, J:90401
cardiac fibrosis J:75420
cardiac hypertrophy J:75420
decreased cardiac output J:90401
decreased ventricle muscle contractility J:90401
dilated cardiomyopathy J:75420, J:90401
dilated heart left ventricle J:90401
fatigue J:75420
heart left ventricle hypertrophy J:75420, J:90401
increased heart iron level J:75420, J:90401
increased mitochondrial fission J:75420
myocardium necrosis J:75420
premature death J:75420, J:90401
prolonged PR interval J:90401
thick interventricular septum J:90401
thick ventricular wall J:75420, J:90401
weight loss J:75420
Fxntm2Mkn/Fxntm2.1Mkn
Tg(Eno2-cre)39Jme/0
involves: 129 * C57BL/6J
abnormal gait J:75420
abnormal motor coordination/balance J:75420
abnormal myocardial fiber morphology J:75420
abnormal nerve conduction J:75420
ataxia J:75420
cardiac fibrosis J:75420
cardiac hypertrophy J:75420
decreased body length J:75420
decreased body weight J:75420
dilated cardiomyopathy J:75420
dilated mitochondria J:75420
hunched posture J:75420
normal muscle phenotype J:75420
myocardium necrosis J:75420
neurodegeneration J:75420
postnatal growth retardation J:75420
premature death J:75420
spongiform encephalopathy J:75420
weight loss J:75420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory