65 phenotypes from 8 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fxnem1(IMPC)J/Fxnem1(IMPC)J C57BL/6NJ-Fxnem1(IMPC)J/J	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Fxnem2Lutzy/Fxnem2.1Lutzy Tg(Ckmm-cre)5Khn/? B6.Cg-Fxnem2Lutzy Fxnem2.1Lutzy Tg(Ckmm-cre)5Khn/J	cardiomyopathy	J:101977
	decreased cardiac muscle contractility	J:101977
	decreased heart rate	J:101977
	increased heart left ventricle weight	J:101977
	premature death	J:101977
Fxntm1.1Pand/Fxntm1Mkn B6.Cg-Fxntm1.1Pand Fxntm1Mkn/J	abnormal mitochondrial biogenesis	J:242978
Fxntm1Mkn/Fxntm1Mkn involves: 129 * C57BL/6J	abnormal extraembryonic tissue morphology	J:62185
	decreased embryo size	J:62185
	embryo tissue necrosis	J:62185
	embryonic growth arrest	J:62185
	embryonic lethality between implantation and somite formation, complete penetrance	J:62185
	normal homeostasis/metabolism phenotype	J:62185
	increased embryonic tissue cell apoptosis	J:62185
Fxntm1Mkn/Fxntm1Pand involves: 129/Sv * C57BL/6	brain inflammation	J:216422
	cardiac fibrosis	J:109164
	increased heart iron level	J:109164
	premature death	J:109164
Fxntm2Mkn/Fxntm2.1Mkn Tg(Ckmm-cre)1Lrsn/0 involves: 129 * C57BL/6J	abnormal iron homeostasis	J:75420
	abnormal mitochondrial morphology	J:90401
	abnormal myocardial fiber mitochondrial morphology	J:75420
	abnormal myocardial fiber morphology	J:75420, J:90401
	abnormal respiratory electron transport chain	J:75420, J:90401
	cardiac fibrosis	J:75420
	cardiac hypertrophy	J:75420
	decreased cardiac output	J:90401
	decreased ventricle muscle contractility	J:90401
	dilated cardiomyopathy	J:75420, J:90401
	dilated heart left ventricle	J:90401
	fatigue	J:75420
	heart left ventricle hypertrophy	J:75420
	increased heart iron level	J:75420, J:90401
	increased heart left ventricle posterior wall thickness	J:90401
	increased heart left ventricle wall thickness	J:75420
	increased heart left ventricle weight	J:90401
	increased mitochondrial fission	J:75420
	myocardium necrosis	J:75420
	premature death	J:75420, J:90401
	prolonged PR interval	J:90401
	thick interventricular septum	J:90401
	weight loss	J:75420
Fxntm2Mkn/Fxntm2.1Mkn Tg(Eno2-cre)39Jme/0 involves: 129 * C57BL/6J	abnormal gait	J:75420
	abnormal motor coordination/balance	J:75420
	abnormal myocardial fiber morphology	J:75420
	abnormal nerve conduction	J:75420
	ataxia	J:75420
	cardiac fibrosis	J:75420
	cardiac hypertrophy	J:75420
	decreased body length	J:75420
	decreased body weight	J:75420
	dilated cardiomyopathy	J:75420
	dilated mitochondrion	J:75420
	hunched posture	J:75420
	normal muscle phenotype	J:75420
	myocardium necrosis	J:75420
	neurodegeneration	J:75420
	postnatal growth retardation	J:75420
	premature death	J:75420
	spongiform encephalopathy	J:75420
	weight loss	J:75420
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg/Gt(ROSA)26Sor+ B6.129-Gt(ROSA)26Sortm1(H1/tetO-RNAi:Fxn)Dhg	abnormal axon morphology	J:254962
	abnormal enzyme/coenzyme activity	J:254962
	abnormal myocardial fiber morphology	J:254962
	abnormal retina pigment epithelium morphology	J:254962
	abnormal sarcomere morphology	J:254962
	absent P wave	J:254962
	ataxia	J:254962
	cardiac fibrosis	J:254962
	cardiomyopathy	J:254962
	decreased grip strength	J:254962
	decreased locomotor activity	J:254962
	decreased myelin sheath thickness	J:254962
	decreased survivor rate	J:254962
	disorganized mitochondrial cristae	J:254962
	dorsal root ganglion degeneration	J:254962
	impaired coordination	J:254962
	increased heart iron level	J:254962
	increased mitochondrial size	J:254962
	premature death	J:254962
	prolonged QT interval	J:254962
	retina photoreceptor degeneration	J:254962
	short stride length	J:254962
	weight loss	J:254962