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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Aqp2
aquaporin 2
MGI:1096865
42 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Aqp2cph/Aqp2cph
C57BL/6J-Aqp2cph
abnormal kidney morphology J:9451, J:109463
abnormal kidney pelvis morphology J:109463
abnormal kidney pyramid morphology J:9451
abnormal urine homeostasis J:109463
alopecia J:9451
colorless urine J:9451
decreased body size J:9451, J:13746, J:109463
decreased body weight J:9451, J:109463
dilated kidney calyx J:9451
dilated kidney collecting duct J:109463
distended abdomen J:9451, J:13746, J:109463
hydronephrosis J:9451, J:109463
hydroureter J:109463
increased blood osmolality J:109463
increased blood urea nitrogen level J:9451, J:109463
infertility J:109463
kidney collecting duct atrophy J:109463
kidney medulla atrophy J:9451
kidney papillary atrophy J:9451
lethargy J:9451, J:109463
polyuria J:109463
postnatal growth retardation J:109463
premature death J:9451, J:13746, J:109463
reduced fertility J:109463
ureterovesical junction obstruction J:9451
Aqp2F204V/Aqp2F204V
C57BL/6-Aqp2F204V
abnormal kidney physiology J:105809
decreased urine osmolality J:105809
hydronephrosis J:105809
normal mortality/aging J:105809
polydipsia J:105809
polyuria J:105809
Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal coat appearance J:121445
abnormal urine osmolality J:121445
decreased body weight J:121445
decreased urine osmolality J:121445
dehydration J:121445
dilated kidney collecting duct J:121445
dry skin J:121445
hydronephrosis J:121445
increased blood urea nitrogen level J:121445
increased hematocrit J:121445
kidney papillary atrophy J:121445
polydipsia J:121445
polyuria J:121445
premature death J:121445
renal interstitial fibrosis J:121445
normal reproductive system phenotype J:121445
Aqp2tm1.1Ask/Aqp2tm1.1Ask
involves: C57BL/6J * FVB/N
abnormal kidney medulla morphology J:94003
abnormal kidney morphology J:94003
decreased urine osmolality J:94003
dilated renal tubules J:94003
increased blood urea nitrogen level J:94003
kidney papillary atrophy J:94003
postnatal lethality, complete penetrance J:94003
Aqp2tm1.1Nlsn/Aqp2tm1.1Nlsn
involves: 129/Sv * C57BL/6
hydronephrosis J:108291
kidney papillary atrophy J:108291
postnatal growth retardation J:108291
postnatal lethality, complete penetrance J:108291
Aqp2tm1Ask/Aqp2tm1Ask
involves: C57BL/6J
abnormal kidney morphology J:94003
decreased urine osmolality J:94003
dehydration J:94003
dilated kidney collecting duct J:94003
increased blood osmolality J:94003
increased blood urea nitrogen level J:94003
kidney medulla atrophy J:94003
kidney medulla cysts J:94003
kidney papillary atrophy J:94003
polyuria J:94003
postnatal lethality, complete penetrance J:94003
Aqp2tm1Bxy/Aqp2tm1Bxy
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * CBA
abnormal urinary bladder morphology J:110648
abnormal urine osmolality J:110648
decreased urine osmolality J:110648
dilated kidney collecting duct J:110648
hydroureter J:110648
kidney medulla atrophy J:110648
polyuria J:110648
Aqp2tm1Nlsn/Aqp2tm1Nlsn
Tg(Hoxb7-cre)13Amc/0
involves: 129/Sv * C57BL/6
decreased urine osmolality J:108291
hydronephrosis J:108291
kidney papillary atrophy J:108291
polyuria J:108291
postnatal lethality, incomplete penetrance J:108291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory