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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Itga8
integrin alpha 8
MGI:109442
34 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Itga8tm1.1Rdav/Itga8tm1.1Rdav
Tg(Camk2a-cre)#Szi/0
involves: 129S6/SvEvTac * C57BL/6J * CBA
normal behavior/neurological phenotype J:170959
impaired synaptic plasticity J:170959
reduced long term potentiation J:170959
Itga8tm1b(KOMP)Wtsi/Itga8+
C57BL/6N-Itga8tm1b(KOMP)Wtsi/J
decreased bone mineral density J:211773
decreased circulating glucose level J:211773
increased circulating calcium level J:211773
increased circulating sodium level J:211773
increased circulating triglyceride level J:211773
Itga8tm1b(KOMP)Wtsi/Itga8tm1b(KOMP)Wtsi
C57BL/6N-Itga8tm1b(KOMP)Wtsi/J
preweaning lethality, incomplete penetrance J:211773
Itga8tm1Lfr/Itga8+
involves: 129X1/SvJ * C57BL/6
normal renal/urinary system phenotype J:122519
Itga8tm1Lfr/Itga8tm1Lfr
involves: 129X1/SvJ * C57BL/6
abnormal branching involved in lung morphogenesis J:154459
abnormal cell adhesion J:154459
abnormal cell migration J:154459
abnormal kidney development J:38838, J:122519
abnormal kidney morphology J:38838
abnormal lung saccule morphology J:154459
abnormal motor coordination/balance J:61486
abnormal pulmonary elastic fiber morphology J:154459
abnormal ureter development J:38838
abnormal ureter morphology J:38838
abnormal ureteric bud invasion J:61486
abnormal vestibular hair cell stereociliary bundle morphology J:61486
absent kidney J:38838, J:122519
absent ureter J:38838
adhesive atelectasis J:154459
decreased vestibular hair cell stereocilia number J:61486
dilated respiratory conducting tubes J:154459
fused right lung lobes J:154459
fused vestibular hair cell stereocilia J:61486
impaired branching involved in ureteric bud morphogenesis J:61486
impaired lung lobe morphogenesis J:154459
postnatal lethality, incomplete penetrance J:38838, J:154459
single kidney J:38838
small kidney J:38838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory