Ucp2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
MGI:109354

33 phenotypes from 3 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Npy-MAPT/Sapphire)1Rck/? Ucp2^{Gt(S20-3G1)Sor}/Ucp2^{Gt(S20-3G1)Sor} involves: C57BL/6 * CBA	abnormal hypothalamus physiology	J:139938
Tg(Pomc-MAPT/Topaz)1Rck/0 Ucp2^{Gt(S20-3G1)Sor}/Ucp2^{Gt(S20-3G1)Sor} involves: C57BL/6 * CBA	abnormal hypothalamus physiology	J:139938
	abnormal synaptic plasticity	J:139938
Ucp2^{Gt(S20-3G1)Sor}/Ucp2^{Gt(S20-3G1)Sor} involves: CD-1	abnormal locomotor behavior	J:113539
	impaired righting response	J:113539
	increased thermal nociceptive threshold	J:113539
Ucp2^{Gt(S20-3G1)Sor}/Ucp2^{Gt(S20-3G1)Sor} Not Specified	abnormal food intake	J:139938
	abnormal hypothalamus morphology	J:139938
	abnormal hypothalamus physiology	J:139938
Ucp2^tm1Lowl/Ucp2^tm1Lowl B6.129S4-Ucp2^tm1Lowl	normal homeostasis/metabolism phenotype	J:272325
	kidney cyst	J:272325
	liver cyst	J:272325
	moribund	J:272325
	pancreas cyst	J:272325
	slow postnatal weight gain	J:272325
Ucp2^tm1Lowl/Ucp2^tm1Lowl involves: 129S4/SvJae * C57BL/6	abnormal cellular respiration	J:96713
	decreased dopamine level	J:96713
	decreased mitochondrial fission	J:96713
	increased susceptibility to dopaminergic neuron neurotoxicity	J:96713
Ucp2^tm1Rcq/Ucp2^tm1Rcq involves: 129X1/SvJ * C57BL/6	abnormal mitochondrial physiology	J:107995, J:133277
	normal cellular phenotype	J:120450
	decreased adiponectin level	J:122094
	decreased cellular sensitivity to oxidative stress	J:107995
	decreased cerebral infarct size	J:107995
	decreased circulating glucose level	J:122094
	decreased circulating lactate level	J:122094
	decreased neuron apoptosis	J:107995
	decreased susceptibility to ischemic brain injury	J:107995
	normal hematopoietic system phenotype	J:120450
	normal homeostasis/metabolism phenotype	J:122094
	normal respiratory system phenotype	J:120450
Ucp2^tm1Rcq/Ucp2^tm1Rcq involves: 129X1/SvJ * C57BL/6J	abnormal macrophage physiology	J:66262
	decreased susceptibility to bacterial infection	J:66262
	decreased susceptibility to infection induced morbidity/mortality	J:66262
	decreased susceptibility to parasitic infection	J:66262
	normal growth/size/body region phenotype	J:66262
	normal homeostasis/metabolism phenotype	J:66262

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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