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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irs2
insulin receptor substrate 2
MGI:109334
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn1btm1Kin/Cdkn1b+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		enlarged pancreatic islets J:96047
increased circulating glucose level J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
Cdkn1btm1Kin/Cdkn1btm1Kin
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		enlarged pancreatic islets J:96047
increased circulating glucose level J:96047
increased circulating insulin level J:96047
increased pancreatic beta cell number J:96047
Foxo1tm1Rdp/Foxo1tm1Rdp
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB 		abnormal triglyceride level J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
normal homeostasis/metabolism phenotype J:137845
Foxo1tm1Whb/Foxo1+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal endocrine/exocrine gland phenotype J:80826
normal homeostasis/metabolism phenotype J:80826
Gsk3btm1Jrw/Gsk3b+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal circulating glucose level J:135659
abnormal pancreatic islet cell apoptosis J:135659
normal growth/size/body region phenotype J:135659
increased circulating glucose level J:135659
increased circulating insulin level J:135659
increased pancreatic beta cell proliferation J:135659
insulin resistance J:135659
Gsk3btm2Jrw/Gsk3btm2Jrw
Irs2tm1Mfw/Irs2tm1Mfw
Tg(Ins2-cre)23Herr/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal circulating glucose level J:135659
increased circulating insulin level J:135659
Insrtm1Dac/Insr+
Irs2tm1Mfw/Irs2tm1Mfw
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal glucose homeostasis J:80826
absent pancreatic beta cells J:80826
postnatal lethality J:80826
Irs1tm1Jos/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell morphology J:93415
decreased body weight J:93415
decreased circulating insulin level J:93415
hyperglycemia J:93415
Irs1tm1Mfw/Irs1+
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
Irs1tm1Mfw/Irs1tm1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal triglyceride level J:137845
decreased body size J:137845
decreased circulating cholesterol level J:137845
decreased circulating free fatty acids level J:137845
decreased circulating HDL cholesterol level J:137845
decreased circulating triglyceride level J:137845
decreased liver glycogen level J:137845
hyperglycemia J:137845
impaired glucose tolerance J:137845
increased circulating glucose level J:137845
increased circulating insulin level J:137845
increased susceptibility to autoimmune diabetes J:137845
insulin resistance J:137845
Irs1tm1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
increased circulating insulin level J:156999
insulin resistance J:156999
Irs1tm1Tka/Irs1tm1Tka
Irs2tm1Tka/Irs2tm1Tka
involves: C57BL/6 * CBA 		abnormal cell differentiation J:68004
decreased white adipose tissue amount J:68004
Irs1tm2.1Mfw/Irs1tm2.1Mfw
Irs2tm2Mfw/Irs2tm2Mfw
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N 		impaired glucose tolerance J:156999
increased circulating insulin level J:156999
Irs1tm2Tka/Irs1tm2Tka
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA 		increased susceptibility to autoimmune diabetes J:137846
insulin resistance J:137846
Irs2tm1Mfw/Irs2tm1Mfw
Ptpn1tm1Bbk/Ptpn1tm1Bbk
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell morphology J:87249
decreased body weight J:87249
hyperglycemia J:87249
impaired glucose tolerance J:87249
increased insulin sensitivity J:87249
pancreatic islet hyperplasia J:87249
premature death J:87249
Irs2tm1Mfw/Irs2tm1Mfw
Tg(Pdx1)#Mmy/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal retina layer morphology J:98107
decreased total retina thickness J:98107
retina outer nuclear layer degeneration J:98107
retina photoreceptor degeneration J:98107
Irs2tm2Mfw/Irs2tm2Mfw
Irs4tm1.1Mfw/Y
Leprtm3(cre)Mgmj/Lepr+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal growth/size/body region phenotype J:221293
normal homeostasis/metabolism phenotype J:221293
Irs2tm2Mfw/Irs2tm2Mfw
Irs4tm1.1Mfw/Y
Tg(Nes-cre)1Kln/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal adipose tissue amount J:221293
abnormal glucose homeostasis J:221293
decreased basal metabolism J:221293
decreased oxygen consumption J:221293
hepatic steatosis J:221293
impaired glucose tolerance J:221293
increased body weight J:221293
increased brown fat cell lipid droplet size J:221293
increased circulating glucose level J:221293
increased circulating insulin level J:221293
increased circulating leptin level J:221293
increased fasting circulating glucose level J:221293
increased food intake J:221293
insulin resistance J:221293
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory