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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298
22 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
ApcMin/Apc+
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Tg(Tie1-cre)9Ref/0
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
decreased tumor growth/size J:262876
ApcMin/Apc+
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Twist2tm1.1(cre)Dor/Twist2+
involves: 129X1/SvJ * BALB/cJ * C57BL/6J
decreased tumor growth/size J:262876
decreased tumor incidence J:262876
ApcMin/Apc+
Mapkapk2tm1.2Gkl/Mapkapk2tm1.2Gkl
involves: BALB/cJ * C57BL/6J
abnormal chemokine secretion J:262876
abnormal survival J:262876
abnormal tumor vascularization J:262876
decreased interleukin-6 secretion J:262876
decreased tumor growth/size J:262876
decreased tumor incidence J:262876
normal hematopoietic system phenotype J:262876
increased intestinal adenoma incidence J:262876
intestine polyps J:262876
Krastm4Tyj/Kras+
Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
involves: 129S4/SvJae * C57BL/6
increased lung adenoma incidence J:203686
Krastm4Tyj/Kras+
Mapkapk2tm1.1Yaff/Mapkapk2tm1.1Yaff
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
increased lung adenoma incidence J:203686
Ldlrtm1Her/Ldlrtm1Her
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
abnormal macrophage derived foam cell morphology J:142788
arteriosclerosis J:142788
decreased macrophage cell number J:142788
increased circulating cholesterol level J:142788
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Mapkapk3tm1.1Lex/Mapkapk3tm1.1Lex
involves: 129P2/OlaHsd * 129S/SvEvBrd * C57BL/6
abnormal cytokine secretion J:117668
normal embryo phenotype J:117668
normal mortality/aging J:117668
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
decreased apoptosis J:108572
granulomatous inflammation J:108572
normal immune system phenotype J:108572
premature death J:108572
small intestinal inflammation J:108572

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory