Gzmb Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gzmb
granzyme B
MGI:109267

8 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fas^tm1Osa/Fas^tm1Osa Gzma^tm1Simn/Gzma^tm1Simn Gzmb^tm1Ley/Gzmb^tm1Ley involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	increased susceptibility to parasitic infection	J:81397
Gzma^tm1Ley/Gzma^tm1Ley Gzmb^tm1Ley/Gzmb^tm1Ley involves: 129X1/SvJ	increased susceptibility to induced morbidity/mortality	J:126114
Gzma^tm1Ley/Gzma^tm1Ley Gzmb^tm2.1Ley/Gzmb^tm2.1Ley involves: 129X1/SvJ	increased susceptibility to induced morbidity/mortality	J:126114
Gzma^tm1Simn/Gzma^tm1Simn Gzmb^tm1Ley/Gzmb^tm1Ley B6.Cg-Gzma^tm1Simn Gzmb^tm1Ley	normal immune system phenotype	J:92718
	increased susceptibility to Flaviviridae infection	J:90852
	increased susceptibility to induced morbidity/mortality	J:90852
	increased susceptibility to parasitic infection	J:81397
Gzma^tm1Simn/Gzma^tm1Simn Gzmb^tm1Ley/Gzmb^tm1Ley involves: 129S2/SvPas * C57BL/6	abnormal leukocyte physiology	J:44204
	normal immune system phenotype	J:44204
Gzma^tm1Simn/Gzma^tm1Simn Gzmb^tm1Ley/Gzmb^tm1Ley Prf1^tm1Sdz/Prf1^tm1Sdz B6.Cg-Gzma^tm1Simn Gzmb^tm1Ley Prf1^tm1Sdz	normal immune system phenotype	J:92718
	increased susceptibility to Flaviviridae infection	J:90852
	increased susceptibility to induced morbidity/mortality	J:90852
	increased susceptibility to parasitic infection	J:81397
Gzmb^tm1Ley/Gzmb^tm1Ley Serpinb9^tm1.1Pib/Serpinb9^tm1.1Pib involves: 129S2/SvPas * BALB/cJ * C57BL/6J	decreased cytotoxic T cell apoptosis	J:252016
Gzmb^tm1Ley/Gzmb^tm1Ley Serpinb9^tm1Arp/Serpinb9^tm1Arp involves: 129S2/SvPas * C57BL/6	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:113349
	abnormal cytotoxic T cell physiology	J:113349

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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