Hfe Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hfe
homeostatic iron regulator
MGI:109191

12 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Unc/B2m^tm1Unc Hfe^tm2Nca/Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	increased liver iron level	J:62112
Cp^m1Cbea/Cp^m1Cbea Hfe^tm1Sly/Hfe^tm1Sly involves: C3H/DiSnA * C57BL/10ScSnA	hemochromatosis	J:122133
Gt(ROSA)26Sor^{tm1(Tfrc)Nca}/Gt(ROSA)26Sor⁺ Hfe^tm2Nca/Hfe^tm2Nca involves: 129S4/SvJae 129S6/SvEvTac * FVB/N	increased circulating iron level	J:133221
	increased liver iron level	J:133221
Heph^sla/Heph^sla Hfe^tm2Nca/Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	increased intestinal iron level	J:62112
	increased liver iron level	J:62112
Heph^sla/Y Hfe^tm2Nca/Hfe^tm2Nca involves: 129S6/SvEvTac * C57BL/6J	increased intestinal iron level	J:62112
	increased liver iron level	J:62112
Hfe^tm1.1Nca/Hfe^tm1.1Nca Tfrc^tm1Nca/Tfrc⁺ Not Specified	increased liver iron level	J:62112
Hfe^tm1Gfn/? Hfem1^C57BL/6/Hfem1^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem1^DBA/2/Hfem1^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem2^C57BL/6/Hfem2^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem2^DBA/2/Hfem2^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem3^DBA/2/Hfem3^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem4^C57BL/6/Hfem4^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm1Gfn/? Hfem4^DBA/2/Hfem4^DBA/2 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	hemochromatosis	J:90494
Hfe^tm2Nca/Hfe^tm2Nca Slc11a2^mk/Slc11a2^mk involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ	decreased liver iron level	J:62112
	postnatal lethality	J:62112
Hfe^tm2Nca/Hfe^tm2Nca Slc11a2^tm1Nca/Slc11a2^tm1Nca involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2^tm1Nca	decreased hematocrit	J:98088
	increased liver iron level	J:98088
	normal mortality/aging	J:98088
	postnatal growth retardation	J:98088
Hfe^tm2Nca/Hfe^tm2Nca Tfrc^tm1Nca/Tfrc⁺ involves: 129S6/SvEvTac	increased liver iron level	J:62112
Hfe^tm2Nca/Hfe^tm2Nca Tg(Ttr-Hfe)1Nca/0 involves: 129S6/SvEvTac * C57BL/6	decreased circulating iron level	J:133221
	decreased liver iron level	J:133221
	hypochromic microcytic anemia	J:133221
Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺ involves: C57BL/6J	increased liver iron level	J:66704
Hfe^tm2Nca/Hfe^tm2Nca Urod^tm1Kush/Urod⁺ involves: C57BL/6J	increased porphyrin level	J:66704

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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