Sirpa Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirpa
signal-regulatory protein alpha
MGI:108563

20 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sirpa^{tm1b(EUCOMM)Hmgu}/Sirpa^{tm1b(EUCOMM)Hmgu} C57BL/6N-Sirpa^{tm1b(EUCOMM)Hmgu}/Bay	abnormal retina outer nuclear layer morphology	J:211773
	decreased blood urea nitrogen level	J:211773
	decreased prepulse inhibition	J:211773
	enlarged spleen	J:211773
	impaired glucose tolerance	J:211773
	increased spleen weight	J:211773
Sirpa^tm1Nog/Sirpa^tm1Nog B6N.129P2-Sirpa^tm1Nog	behavioral despair	J:162849
Sirpa^tm1Nog/Sirpa^tm1Nog involves: 129P2/OlaHsd * C57BL/6	abnormal Langerhans cell physiology	J:88694
	abnormal macrophage physiology	J:79592
	decreased body weight	J:79592
	decreased T cell number	J:79592
	hepatic steatosis	J:79592
	increased megakaryocyte cell number	J:79592
	thrombocytopenia	J:79592
Sirpa^tm1Umri/Sirpa^tm1Umri Tg(CAG-cre/Esr1)1Lbe/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6	abnormal excitatory postsynaptic potential	J:204011
	abnormal synapse morphology	J:204011
	abnormal synaptic vesicle morphology	J:204011
	abnormal synaptic vesicle number	J:204011
	enhanced paired-pulse facilitation	J:204011
	reduced long-term potentiation	J:204011

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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